pti.html

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<!-- Page Title: Trypsin Inhibitor -->
<h2>Introduction</h2>
<p>
    These scripts show the complex between the pancreatic trypsin inhibitor
    (PTI) and trypsin. PTI is a small protein, Mr = 8 kDa. PTI binds to trypsin
    with high affinity because it contains a peptide bond that is a transition
    state analog. (Based on 2ptc.pdb, Marquart et al. (1983)
    Acta Crystallogr.,Sect.B <strong>39</strong>: 480)
</p>
<br>

<h2>PTI 1</h2>
<p>
    This is the complex between <span style="color:green;">PTI</span> and
    <span style="color:gray;">Trypsin</span>.
</p>
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<!-- UI Control Box -->
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    <input type="checkbox" id="spinBox1"> Spin On/Off
</div>
<br>

<h2>PTI 2</h2>
<p>
    A <span style="color:red">Lys</span> of the inhibitor binds in the
    specificity pocket of trypsin.
</p>
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</div>
<br>

<h2>PTI 3</h2>
<p>
    The peptide bond between the Lys and Ala is distorted, which forces the
    <span style="color:green;">carbonyl oxygen</span> of the peptide bond into
    the oxyanion hole.
</p>
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</div>
<br>

<h2>PTI 4</h2>
<p>
    The peptide bond involving the Lys is non planar and resembles the reaction
    transition state - this inhibitor is a natural transition state analog.
</p>
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