DRAO-full.obo

format-version: 1.2
data-version: http://www.fairsharing.org/ontology/domain/DRAO/releases/2025-06-16/DRAO-full.owl
idspace: biomodels http://biomodels.net/SBO/ 
idspace: dce http://purl.org/dc/elements/1.1/ 
idspace: dcterms http://purl.org/dc/terms/ 
idspace: drao http://www.fairsharing.org/ontology/domain/ 
idspace: edam http://edamontology.org/ 
idspace: efo http://www.ebi.ac.uk/efo/ 
idspace: mamo http://identifiers.org/mamo/ 
idspace: oboInOwl http://www.geneontology.org/formats/oboInOwl# 
idspace: orpha http://www.orpha.net/ORDO/ 
idspace: semsci http://semanticscience.org/resource/ 
idspace: swo http://www.ebi.ac.uk/swo/ 
idspace: swodata http://www.ebi.ac.uk/swo/data/ 
idspace: swointerface http://www.ebi.ac.uk/swo/interface/ 
ontology: http://www.fairsharing.org/ontology/domain/DRAO/DRAO-full.owl
property_value: dcterms:description "The Domain Resource Application Ontology (DRAO) contains terms from over 40 community ontologies, as listed at https://github.com/FAIRsharing/domain-ontology/blob/master/LicensingCompliance.md.\n\nThese ontologies were added to DRAO through semi-automated procedures using the ODK; full details are available at https://github.com/FAIRsharing/domain-ontology. Licensing information can be found at https://github.com/FAIRsharing/domain-ontology/blob/master/LicensingCompliance.md\n\nAgroVoc and PRIDE classes were manually added as required.\n\nOriginally developed for use within FAIRsharing.org\n\nLicensed under the Creative Commons Attribution 4.0 International (CC BY 4.0), https://creativecommons.org/licenses/by/4.0/" xsd:string
property_value: dcterms:license https://creativecommons.org/licenses/by/4.0/
property_value: dcterms:title "Domain Resource Application Ontology" xsd:string
property_value: owl:versionInfo "2025-06-16" xsd:string

[Term]
id: BFO:0000001
name: entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/oae.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obcs.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omrse.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/t4fs.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/vo.owl

[Term]
id: BFO:0000002
name: continuant
def: "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." []
is_a: BFO:0000001 ! entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obcs.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omrse.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/vo.owl

[Term]
id: BFO:0000003
name: occurent
def: "An entity that has temporal parts and that happens, unfolds or develops through time." []
is_a: BFO:0000001 ! entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/oae.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/t4fs.owl

[Term]
id: BFO:0000004
name: independent continuant
def: "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])" []
is_a: BFO:0000002 ! continuant
property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omrse.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/vo.owl

[Term]
id: BFO:0000015
name: process
def: "A process is an entity that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity during the time it occurs." []
is_a: BFO:0000003 ! occurent
property_value: IAO:0000412 efo:efo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/oae.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/t4fs.owl

[Term]
id: BFO:0000016
name: disposition
is_a: BFO:0000017 ! realizable entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl

[Term]
id: BFO:0000017
name: realizable entity
def: "A specifically dependent continuant  that inheres in continuant  entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances." []
is_a: BFO:0000020 ! specifically dependent continuant
property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl

[Term]
id: BFO:0000019
name: quality
is_a: BFO:0000020 ! specifically dependent continuant
property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl

[Term]
id: BFO:0000020
name: specifically dependent continuant
def: "b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n > 1 independent continuants c1, … cn which are not spatial regions are such that for all 1  i < j  n, ci  and cj share no common parts, are such that for each 1  i  n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004])" []
is_a: BFO:0000002 ! continuant
property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl

[Term]
id: BFO:0000023
name: role
def: "A realizable entity  the manifestation of which brings about some result or end that is not essential to a continuant  in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant  in some kinds of natural, social or institutional contexts." []
is_a: BFO:0000017 ! realizable entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: BFO:0000030
name: object
is_a: BFO:0000040 ! material entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: BFO:0000031
name: generically dependent continuant
def: "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time." []
is_a: BFO:0000002 ! continuant
property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obcs.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/stato.owl

[Term]
id: BFO:0000034
name: function
is_a: BFO:0000016 ! disposition
property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000040
name: material entity
def: "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." []
is_a: BFO:0000004 ! independent continuant
property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omrse.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/vo.owl

[Term]
id: CHEBI:15339
name: acceptor
def: "A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity." []
subset: https://www.fairsharing.org
is_a: CHEBI:51086 ! chemical role
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:15358
name: histone
subset: https://www.fairsharing.org
is_a: CHEBI:33695 ! information biomacromolecule
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:15378
name: hydron
def: "The general name for the hydrogen nucleus, to be used without regard to the hydrogen nuclear mass (either for hydrogen in its natural abundance or where it is not desired to distinguish between the isotopes)." []
is_a: CHEBI:23906 ! monoatomic cation
is_a: CHEBI:33251 ! monoatomic hydrogen
is_a: CHEBI:36347 ! nuclear particle
is_a: CHEBI:36915 ! inorganic cation
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:15986
name: polynucleotide
def: "A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues." []
is_a: CHEBI:33695 ! information biomacromolecule
is_a: CHEBI:61120 ! nucleobase-containing molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:16646
name: carbohydrate
def: "Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates." []
subset: https://www.fairsharing.org
is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:16670
name: peptide
def: "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc." []
subset: https://www.fairsharing.org
is_a: CHEBI:37622 ! carboxamide
is_a: CHEBI:50047 ! organic amino compound
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:16991
name: deoxyribonucleic acid
def: "High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms." []
subset: https://www.fairsharing.org
is_a: CHEBI:33696 ! nucleic acid
property_value: IAO:0000118 "DNA" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: CHEBI:17234
name: glucose
def: "An aldohexose used as a source of energy and metabolic intermediate." []
subset: https://www.fairsharing.org
is_a: CHEBI:16646 ! carbohydrate
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:17891
name: donor
def: "A molecular entity that can transfer (\"donate\") an electron, a pair of electrons, an atom or a group to another molecular entity." []
subset: https://www.fairsharing.org
is_a: CHEBI:51086 ! chemical role
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:18059
name: lipid
def: "'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids." []
subset: https://www.fairsharing.org
is_a: CHEBI:50860 ! organic molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:18111
name: ribosomal RNA
def: "RNA molecules which are essential structural and functional components of ribosomes, the subcellular units responsible for protein synthesis." []
subset: https://www.fairsharing.org
is_a: CHEBI:33697 ! ribonucleic acid
property_value: IAO:0000118 "rRNA" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:18154
name: polysaccharide
def: "A biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically. This term is commonly used only for those containing more than ten monosaccharide residues." []
subset: https://www.fairsharing.org
is_a: CHEBI:16646 ! carbohydrate
is_a: CHEBI:33694 ! biomacromolecule
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:23367
name: molecular entity
def: "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." []
subset: https://www.fairsharing.org
is_a: CHEBI:24431 ! chemical entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: CHEBI:23888
name: drug
def: "Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances." []
subset: https://www.fairsharing.org
is_a: CHEBI:33232 ! application
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:23906
name: monoatomic cation
is_a: CHEBI:24867 ! monoatomic ion
is_a: CHEBI:36916 ! cation
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:24431
name: chemical entity
def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." []
subset: https://www.fairsharing.org
is_a: BFO:0000030 ! object
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:24432
name: biological role
def: "A role played by the molecular entity or part thereof within a biological context." []
is_a: BFO:0000023 ! role
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:24532
name: organic heterocyclic compound
def: "A cyclic compound having as ring members atoms of carbon and at least of one other element." []
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:33832 ! organic cyclic compound
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:24636
name: proton
def: "Nuclear particle of charge number +1, spin 1/2 and rest mass of 1.007276470(12) u." []
subset: https://www.fairsharing.org
is_a: CHEBI:15378 ! hydron
is_a: CHEBI:33253 ! nucleon
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:24835
name: inorganic molecular entity
def: "A molecular entity that contains no carbon." []
is_a: CHEBI:23367 ! molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:24867
name: monoatomic ion
is_a: CHEBI:24870 ! ion
is_a: CHEBI:33238 ! monoatomic entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:24870
name: ion
def: "A molecular entity having a net electric charge." []
is_a: CHEBI:23367 ! molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:25212
name: metabolite
def: "Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites." []
subset: https://www.fairsharing.org
is_a: CHEBI:24432 ! biological role
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:25367
name: molecule
def: "Any polyatomic entity that is an electrically neutral entity consisting of more than one atom." []
is_a: CHEBI:36357 ! polyatomic entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:25442
name: mycotoxin
def: "Poisonous substance produced by fungi." []
subset: https://www.fairsharing.org
is_a: CHEBI:27026 ! toxin
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:25608
name: nucleoside phosphate
def: "A nucleobase-containing molecular entity that is a nucleoside in which one or more of the sugar hydroxy groups has been converted into a mono- or poly-phosphate. The term includes both nucleotides and non-nucleotide nucleoside phosphates." []
is_a: CHEBI:25703 ! organic phosphate
is_a: CHEBI:37734 ! phosphoric ester
is_a: CHEBI:61120 ! nucleobase-containing molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:25703
name: organic phosphate
is_a: CHEBI:25710 ! organophosphorus compound
is_a: CHEBI:26079 ! phosphoric acid derivative
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:25710
name: organophosphorus compound
def: "An organophosphorus compound is formally a compound containing at least one carbon-phosphorus bond, but the term is often extended to include esters and thioesters." []
is_a: CHEBI:26082 ! phosphorus molecular entity
is_a: CHEBI:33285 ! heteroorganic entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:26079
name: phosphoric acid derivative
is_a: CHEBI:36359 ! phosphorus oxoacid derivative
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:26082
name: phosphorus molecular entity
is_a: CHEBI:33302 ! pnictogen molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:27026
name: toxin
def: "Poisonous substance produced by a biological organism such as a microbe, animal or plant." []
is_a: CHEBI:25212 ! metabolite
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33232
name: application
def: "Intended use of the molecular entity or part thereof by humans." []
is_a: BFO:0000023 ! role
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33238
name: monoatomic entity
def: "A monoatomic entity is a molecular entity consisting of a single atom." []
is_a: CHEBI:33259 ! elemental molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33251
name: monoatomic hydrogen
is_a: CHEBI:33238 ! monoatomic entity
is_a: CHEBI:33260 ! elemental hydrogen
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33253
name: nucleon
def: "Heavy nuclear particle: proton or neutron." []
is_a: CHEBI:36347 ! nuclear particle
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33259
name: elemental molecular entity
def: "A molecular entity all atoms of which have the same atomic number." []
is_a: CHEBI:23367 ! molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33260
name: elemental hydrogen
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:33259 ! elemental molecular entity
is_a: CHEBI:33579 ! main group molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33281
name: antimicrobial agent
def: "A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans." []
subset: https://www.fairsharing.org
is_a: CHEBI:24432 ! biological role
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33284
name: nutrient
def: "A nutrient is a food component that an organism uses to survive and grow." []
subset: https://www.fairsharing.org
is_a: CHEBI:52211 ! physiological role
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33285
name: heteroorganic entity
def: "A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms." []
is_a: CHEBI:50860 ! organic molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33290
name: food
def: "A physiological role played by any substance of either plant, animal or artificial origin which contains essential body nutrients that can be ingested by an organism to provide energy, promote growth, and maintain the processes of life." []
subset: https://www.fairsharing.org
is_a: CHEBI:52211 ! physiological role
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33302
name: pnictogen molecular entity
def: "A p-block molecular entity containing any pnictogen." []
is_a: CHEBI:33675 ! p-block molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33304
name: chalcogen molecular entity
def: "Any p-block molecular entity containing a chalcogen." []
is_a: CHEBI:33675 ! p-block molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33579
name: main group molecular entity
def: "A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table." []
is_a: CHEBI:23367 ! molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33595
name: cyclic compound
def: "Any molecule that consists of a series of atoms joined together to form a ring." []
is_a: CHEBI:25367 ! molecule
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33659
name: organic aromatic compound
is_a: CHEBI:33832 ! organic cyclic compound
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33675
name: p-block molecular entity
def: "A main group molecular entity that contains one or more atoms of a p-block element." []
is_a: CHEBI:33579 ! main group molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33694
name: biomacromolecule
def: "A macromolecule formed by a living organism." []
is_a: CHEBI:36357 ! polyatomic entity
is_a: CHEBI:50860 ! organic molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33695
name: information biomacromolecule
is_a: CHEBI:33694 ! biomacromolecule
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33696
name: nucleic acid
def: "A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid." []
subset: https://www.fairsharing.org
is_a: CHEBI:15986 ! polynucleotide
is_a: CHEBI:33839 ! macromolecule
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: CHEBI:33697
name: ribonucleic acid
def: "High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins." []
subset: https://www.fairsharing.org
is_a: CHEBI:33696 ! nucleic acid
property_value: IAO:0000118 "RNA" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33708
name: amino-acid residue
def: "When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue." []
is_a: CHEBI:24431 ! chemical entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33711
name: C-terminal amino-acid residue
def: "The residue in a peptide that has a free carboxyl group, or at least does not acylate another amino-acid residue, is called C-terminal." []
subset: https://www.fairsharing.org
is_a: CHEBI:33708 ! amino-acid residue
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33712
name: N-terminal amino-acid residue
def: "The residue in a peptide that has an amino group that is free, or at least not acylated by another amino-acid residue, is called N-terminal." []
subset: https://www.fairsharing.org
is_a: CHEBI:33708 ! amino-acid residue
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33832
name: organic cyclic compound
def: "Any organic molecule that consists of atoms connected in the form of a ring." []
is_a: CHEBI:33595 ! cyclic compound
is_a: CHEBI:72695 ! organic molecule
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33833
name: heteroarene
def: "A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2)." []
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:33659 ! organic aromatic compound
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:33839
name: macromolecule
def: "A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." []
is_a: CHEBI:23367 ! molecular entity
property_value: IAO:0000118 "polymer" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: CHEBI:33893
name: reagent
def: "A substance used in a chemical reaction to detect, measure, examine, or produce other substances." []
subset: https://www.fairsharing.org
is_a: CHEBI:33232 ! application
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:35352
name: organonitrogen compound
def: "Any heteroorganic entity containing at least one carbon-nitrogen bond." []
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:51143 ! nitrogen molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:36342
name: subatomic particle
def: "A particle smaller than an atom." []
is_a: BFO:0000040 ! material entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:36347
name: nuclear particle
def: "A nucleus or any of its constituents in any of their energy states." []
is_a: CHEBI:36342 ! subatomic particle
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:36357
name: polyatomic entity
def: "Any molecular entity consisting of more than one atom." []
is_a: CHEBI:23367 ! molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:36359
name: phosphorus oxoacid derivative
is_a: CHEBI:26082 ! phosphorus molecular entity
is_a: CHEBI:36357 ! polyatomic entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:36914
name: inorganic ion
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:24870 ! ion
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:36915
name: inorganic cation
is_a: CHEBI:36914 ! inorganic ion
is_a: CHEBI:36916 ! cation
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:36916
name: cation
def: "A monoatomic or polyatomic species having one or more elementary charges of the proton." []
is_a: CHEBI:24870 ! ion
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:36962
name: organochalcogen compound
def: "An organochalcogen compound is a compound containing at least one carbon-chalcogen bond." []
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:33304 ! chalcogen molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:36963
name: organooxygen compound
def: "An organochalcogen compound containing at least one carbon-oxygen bond." []
is_a: CHEBI:36962 ! organochalcogen compound
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:36976
name: nucleotide
def: "A nucleotide is a nucleoside phosphate resulting from the condensation of the 3 or 5 hydroxy group of a nucleoside with phosphoric acid." []
subset: https://www.fairsharing.org
is_a: CHEBI:25608 ! nucleoside phosphate
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:37622
name: carboxamide
def: "An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom." []
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:36963 ! organooxygen compound
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:37734
name: phosphoric ester
is_a: CHEBI:26079 ! phosphoric acid derivative
is_a: CHEBI:36963 ! organooxygen compound
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:4705
name: double-stranded DNA
is_a: CHEBI:16991 ! deoxyribonucleic acid
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: CHEBI:50047
name: organic amino compound
def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups." []
is_a: CHEBI:35352 ! organonitrogen compound
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:50406
name: probe
def: "A role played by a molecular entity used to study the microscopic environment." []
subset: https://www.fairsharing.org
is_a: CHEBI:33232 ! application
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:50803
name: nanoparticle
def: "A nanosized spherical or capsule-shaped structure." []
subset: https://www.fairsharing.org
is_a: CHEBI:36357 ! polyatomic entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:50860
name: organic molecular entity
def: "Any molecular entity that contains carbon." []
is_a: CHEBI:33675 ! p-block molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:51086
name: chemical role
def: "A role played by the molecular entity or part thereof within a chemical context." []
is_a: BFO:0000023 ! role
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:51087
name: protecting group
def: "A group that is introduced into a molecule by chemical modification of a functional group in order to obtain chemoselectivity in a subsequent chemical reaction." []
subset: https://www.fairsharing.org
is_a: CHEBI:33232 ! application
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:51143
name: nitrogen molecular entity
is_a: CHEBI:33302 ! pnictogen molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:52211
name: physiological role
is_a: CHEBI:24432 ! biological role
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:52214
name: ligand
def: "Any molecule or ion capable of binding to a central metal atom to form coordination complexes." []
subset: https://www.fairsharing.org
is_a: CHEBI:51086 ! chemical role
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:59132
name: antigen
def: "Any substance that stimulates an immune response in the body, such as through antibody production or by presentation to a T-cell receptor after binding to a major histocompability complex (MHC)." []
subset: https://www.fairsharing.org
is_a: CHEBI:24432 ! biological role
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:59163
name: biomarker
def: "A substance used as an indicator  of a biological state." []
subset: https://www.fairsharing.org
is_a: CHEBI:33232 ! application
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:61120
name: nucleobase-containing molecular entity
def: "Any compound that has a nucleobase as a part." []
is_a: CHEBI:33833 ! heteroarene
is_a: CHEBI:51143 ! nitrogen molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:72695
name: organic molecule
def: "Any molecule that consists of at least one carbon atom as part of the electrically neutral entity." []
is_a: CHEBI:25367 ! molecule
is_a: CHEBI:50860 ! organic molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:78298
name: environmental contaminant
def: "Any minor or unwanted substance introduced into the environment that can have undesired effects." []
subset: https://www.fairsharing.org
is_a: CHEBI:51086 ! chemical role
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHEBI:78616
name: carbohydrates and carbohydrate derivatives
def: "Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation." []
is_a: CHEBI:36963 ! organooxygen compound
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl

[Term]
id: CHMO:0000067
name: microscopy
def: "Any technique where a microscope is used to view a small object (or specimen) by producing a magnified image." []
subset: https://www.fairsharing.org
is_a: OBI:0000185 ! imaging assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CHMO:0000068
name: electron microscopy
def: "Microscopy where the specimen is bombarded with a finely focused (<10 nm diameter) electron beam with an acceleration voltage 50-150 kV under vacuum. The interaction of the electrons with the specimen produces transmitted, secondary, backscattered and diffracted electrons and characteristic X-rays which are detected." []
subset: https://www.fairsharing.org
is_a: CHMO:0000067 ! microscopy
property_value: IAO:0000118 "EM" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CHMO:0000102
name: optical microscopy
def: "Microscopy where the specimen is illuminated with visible light and a system of lenses is used to produce an image." []
subset: https://www.fairsharing.org
is_a: CHMO:0000067 ! microscopy
property_value: IAO:0000118 "light microscopy" xsd:string
property_value: IAO:0000118 "OM" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CHMO:0000104
name: bright-field microscopy
def: "Microscopy where the specimen is illuminated with light transmitted from a source on the opposite side of the specimen from the objective." []
is_a: CHMO:0000102 ! optical microscopy
property_value: IAO:0000118 "bright field microscopy" xsd:string
property_value: IAO:0000118 "bright-field optical microscopy" xsd:string
property_value: IAO:0000118 "transmitted light microscopy" xsd:string
property_value: IAO:0000118 "transmitted-light microscopy" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CHMO:0000140
name: reciprocal-space method
def: "Any detection or measurement method for a set of points in reciprocal space." []
is_a: OBI:0000070 ! assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CHMO:0000141
name: diffraction method
def: "Any detection or measurement method where the structure of a crystal or molecule can be determined by directing a beam of particles or radiation at a sample and recording the resulting diffraction pattern." []
is_a: CHMO:0000140 ! reciprocal-space method
property_value: IAO:0000118 "crystallography" xsd:string
property_value: IAO:0000118 "diffraction analysis" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CHMO:0000156
name: X-ray diffraction
def: "A method for determining structure by directing a beam of X-rays at the sample and detecting the positions and intensities of the diffracted X-rays as a pattern of spots on a photographic plate." []
subset: https://www.fairsharing.org
is_a: CHMO:0000141 ! diffraction method
property_value: IAO:0000118 "X-ray analysis" xsd:string
property_value: IAO:0000118 "X-Ray crystallographic analysis" xsd:string
property_value: IAO:0000118 "X-ray crystallography" xsd:string
property_value: IAO:0000118 "X-ray diffraction analysis" xsd:string
property_value: IAO:0000118 "X-ray diffractometry" xsd:string
property_value: IAO:0000118 "X-ray structure determination" xsd:string
property_value: IAO:0000118 "XRD" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CHMO:0000228
name: spectroscopy
def: "The study of the interaction of a sample with radiation or particles for measurement or detection." []
subset: https://www.fairsharing.org
is_a: OBI:0000070 ! assay
property_value: IAO:0000118 "spectrometry" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CHMO:0000591
name: nuclear magnetic resonance spectroscopy
def: "Spectroscopy where the energy states of spin-active nuclei placed in a static magnetic field are interrogated by inducing transitions between the states via radio frequency irradiation." []
subset: https://www.fairsharing.org
is_a: CHMO:0001806 ! nuclear magnetic resonance method
property_value: IAO:0000118 "NMR" xsd:string
property_value: IAO:0000118 "NMR spectrometry" xsd:string
property_value: IAO:0000118 "NMR spectroscopy" xsd:string
property_value: IAO:0000118 "nuclear magnetic resonance (NMR) spectroscopy" xsd:string
property_value: IAO:0000118 "nuclear magnetic resonance spectrometry" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CHMO:0000656
name: Raman spectroscopy
def: "Spectroscopy where the Raman scattering of monochromatic light, usually from a laser in the visible, near infrared, or near ultraviolet range by a sample is detected." []
subset: https://www.fairsharing.org
is_a: CHMO:0002414 ! scattering spectroscopy
property_value: IAO:0000118 "Raman scattering spectrometry" xsd:string
property_value: IAO:0000118 "Raman scattering spectroscopy" xsd:string
property_value: IAO:0000118 "Raman spectrometry" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CHMO:0000793
name: assay output
def: "An information content entity that is output by an assay." []
is_a: IAO:0000027 ! data item
property_value: IAO:0000118 "experimental data" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CHMO:0000800
name: spectrum
def: "A plot of a measured quantity against some experimental parameter." []
subset: https://www.fairsharing.org
is_a: CHMO:0000793 ! assay output
property_value: IAO:0000118 "spectra" xsd:string
property_value: IAO:0000118 "spectrum plot" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CHMO:0000999
name: separation method
def: "A method that results in the separation of two or more components according to some property." []
is_a: OBI:0000094 ! material processing
property_value: IAO:0000118 "partition" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CHMO:0001000
name: chromatography
def: "A separation method where the components are distributed between two phases, one of which is stationary, while the other moves in a definite direction." []
subset: https://www.fairsharing.org
is_a: CHMO:0000999 ! separation method
property_value: IAO:0000118 "analytical chromatography" xsd:string
property_value: IAO:0000118 "chromatographic analysis" xsd:string
property_value: IAO:0000118 "preparative chromatography" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CHMO:0001001
name: column chromatography
def: "A chromatography method where the stationary bed is within a tube (of standard length 25 cm). The particles of the solid stationary phase or support coated with a liquid stationary phase may fill the whole inside volume of the tube (packed column) or be concentrated on or along the inside tube wall leaving an open, unrestricted path for the mobile phase in the middle part of the tube (open-tubular column)." []
is_a: CHMO:0001000 ! chromatography
property_value: IAO:0000118 "preparative column chromatography" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CHMO:0001002
name: gas chromatography
def: "Column chromatography where the mobile phase is a gas." []
subset: https://www.fairsharing.org
is_a: CHMO:0001001 ! column chromatography
property_value: IAO:0000118 "GC" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CHMO:0001112
name: super-resolution bright-field microscopy
def: "Microscopy where the specimen is illuminated with light transmitted from a source on the opposite side of the specimen from the objective, and image resolution (which is normally limited by diffraction) is enhanced by processing the images with image restoration algorithms." []
subset: https://www.fairsharing.org
is_a: CHMO:0000104 ! bright-field microscopy
property_value: IAO:0000118 "super resolution bright field microscopy" xsd:string
property_value: IAO:0000118 "super resolution bright field optical microscopy" xsd:string
property_value: IAO:0000118 "super-resolution bright-field optical microscopy" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CHMO:0001215
name: magnetic resonance method
def: "Any technique which detects the response of spins to a perturbing magnetic field." []
is_a: OBI:0000070 ! assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CHMO:0001806
name: nuclear magnetic resonance method
def: "A technique or procedure applied in nuclear magnetic resonance experiments." []
is_a: CHMO:0001215 ! magnetic resonance method
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CHMO:0002414
name: scattering spectroscopy
def: "Any method that measures the amount of light that a substance scatters at certain wavelengths, incident angles, and polarization angles." []
is_a: CHMO:0000228 ! spectroscopy
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: CL:0000000
name: cell
def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." []
subset: https://www.fairsharing.org
is_a: UBERON:0000061 ! anatomical structure
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000010
name: cultured cell
is_a: CL:0000578 ! experimentally modified cell in vitro
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl

[Term]
id: CL:0000034
name: stem cell
def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." []
subset: https://www.fairsharing.org
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0011115 ! precursor cell
property_value: IAO:0000118 "animal stem cell" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000084
name: T cell
def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." []
subset: https://www.fairsharing.org
is_a: CL:0000542 ! lymphocyte
property_value: IAO:0000118 "T lymphocyte" xsd:string
property_value: IAO:0000118 "T-cell" xsd:string
property_value: IAO:0000118 "T-lymphocyte" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000113
name: mononuclear phagocyte
def: "A vertebrate phagocyte with a single nucleus." []
is_a: CL:0000518 ! phagocyte (sensu Vertebrata)
is_a: CL:0000842 ! mononuclear leukocyte
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000145
name: professional antigen presenting cell
def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." []
is_a: CL:0000738 ! leukocyte
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000211
name: electrically active cell
def: "A cell whose function is determined by the generation or the reception of an electric signal." []
is_a: CL:0000000 ! cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000219
name: motile cell
def: "A cell that moves by its own activities." []
is_a: CL:0000000 ! cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000226
name: single nucleate cell
def: "A cell with a single nucleus." []
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002242 ! nucleate cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000234
name: phagocyte
def: "Any cell capable of ingesting particulate matter via phagocytosis." []
is_a: CL:0000219 ! motile cell
is_a: CL:0000325 ! stuff accumulating cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000255
name: eukaryotic cell
def: "Any cell that in taxon some Eukaryota." []
is_a: CL:0000000 ! cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000325
name: stuff accumulating cell
def: "A cell that is specialised to accumulate a particular substance(s)." []
is_a: CL:0000000 ! cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000393
name: electrically responsive cell
def: "A cell whose function is determined by its response to an electric signal." []
is_a: CL:0000211 ! electrically active cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000404
name: electrically signaling cell
def: "A cell that initiates an electrical signal and passes that signal to another cell." []
is_a: CL:0000211 ! electrically active cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000451
name: dendritic cell
def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." []
subset: https://www.fairsharing.org
is_a: CL:0000113 ! mononuclear phagocyte
is_a: CL:0000145 ! professional antigen presenting cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000518
name: phagocyte (sensu Vertebrata)
def: "A phagocyte in vertebrates that is able to phagocytosis." []
is_a: CL:0000234 ! phagocyte
is_a: CL:0000255 ! eukaryotic cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000540
name: neuron
def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." []
subset: https://www.fairsharing.org
is_a: CL:0000393 ! electrically responsive cell
is_a: CL:0000404 ! electrically signaling cell
is_a: CL:0002319 ! neural cell
property_value: IAO:0000118 "nerve cell" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000542
name: lymphocyte
def: "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." []
is_a: CL:0000842 ! mononuclear leukocyte
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000578
name: experimentally modified cell in vitro
is_a: CL:0001034 ! cell in vitro
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl

[Term]
id: CL:0000723
name: somatic stem cell
def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." []
is_a: CL:0000034 ! stem cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000738
name: leukocyte
def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." []
is_a: CL:0000219 ! motile cell
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000988 ! hematopoietic cell
is_a: CL:0002242 ! nucleate cell
property_value: IAO:0000118 "leucocyte" xsd:string
property_value: IAO:0000118 "white blood cell" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000842
name: mononuclear leukocyte
def: "A leukocyte with a single non-segmented nucleus in the mature form." []
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0000738 ! leukocyte
property_value: IAO:0000118 "mononuclear cell" xsd:string
property_value: IAO:0000118 "peripheral blood mononuclear cell" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0000988
name: hematopoietic cell
def: "A cell of a hematopoietic lineage." []
is_a: CL:0000000 ! cell
property_value: IAO:0000118 "haematopoietic cell" xsd:string
property_value: IAO:0000118 "haemopoietic cell" xsd:string
property_value: IAO:0000118 "hemopoietic cell" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0001034
name: cell in vitro
is_a: CL:0000000 ! cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl

[Term]
id: CL:0002242
name: nucleate cell
def: "A cell containing at least one nucleus." []
is_a: CL:0000000 ! cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0002248
name: pluripotent stem cell
def: "A pluripotent stem cell has the ability to form cells from all three germ layers (ectoderm, mesoderm, and endoderm). However, unlike totipotent stem cells, they cell can not generate all the cells of the whole organism such as placenta." []
subset: https://www.fairsharing.org
is_a: CL:0000723 ! somatic stem cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0002319
name: neural cell
def: "A cell that is part of the nervous system." []
is_a: CL:0000255 ! eukaryotic cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0002321
name: embryonic cell (metazoa)
def: "A cell of the embryo." []
is_a: CL:0000000 ! cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0002322
name: embryonic stem cell
def: "A stem cell of embryonic origin." []
subset: https://www.fairsharing.org
is_a: CL:0000034 ! stem cell
is_a: CL:0002321 ! embryonic cell (metazoa)
property_value: IAO:0000118 "ESC" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CL:0011115
name: precursor cell
def: "A cell that, by division or terminal differentiation, can give rise to other cell types." []
is_a: CL:0000000 ! cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl

[Term]
id: CLO:0000001
name: cell line cell
is_a: OBI:0001866 ! secondary cultured cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl

[Term]
id: CLO:0000031
name: cell line
subset: https://www.fairsharing.org
is_a: OBI:0001905 ! secondary cultured cell population
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl

[Term]
id: CLO:0036932
name: Hybridoma
subset: https://www.fairsharing.org
is_a: UnspecifiedCellType ! unspecified cell type
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl

[Term]
id: CLO:0037224
name: stem cell line cell
is_a: CLO:0000001 ! cell line cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl

[Term]
id: CLO:0037279
name: embryonic stem cell line cell
is_a: CLO:0037224 ! stem cell line cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl

[Term]
id: CLO:0037280
name: human embryonic stem cell line cell
subset: https://www.fairsharing.org
is_a: CLO:0037279 ! embryonic stem cell line cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl

[Term]
id: CLO:0037307
name: induced pluripotent stem cell line cell
is_a: CLO:0037224 ! stem cell line cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl

[Term]
id: CLO:0037308
name: human induced pluripotent stem cell line cell
subset: https://www.fairsharing.org
is_a: CLO:0037307 ! induced pluripotent stem cell line cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl

[Term]
id: CMO:0000000
name: clinical measurement
def: "A quantitative or qualitative value which is the result of an act of assessing a morphological or physiological state or property in a single individual or sample or a group of individuals or samples, based on direct observation or experimental manipulation." []
is_a: efo:EFO_0001444 ! measurement
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cmo.owl

[Term]
id: CMO:0001108
name: disease onset/diagnosis measurement
def: "Any measurement which expresses a quantity related to the beginning, early stages or development of a disease, or to the official determination of a disease as the cause of the observed symptom(s)." []
subset: https://www.fairsharing.org
is_a: CMO:0000000 ! clinical measurement
property_value: IAO:0000412 http://purl.obolibrary.org/obo/cmo.owl

[Term]
id: DOID:0060037
name: developmental disorder of mental health
def: "A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development." []
is_a: DOID:150 ! disease of mental health
property_value: IAO:0000412 http://purl.obolibrary.org/obo/doid.owl

[Term]
id: DOID:0080001
name: bone disease
def: "A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function." []
subset: https://www.fairsharing.org
is_a: DOID:7 ! disease of anatomical entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/doid.owl

[Term]
id: DOID:12365
name: malaria
def: "A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle." []
subset: https://www.fairsharing.org
is_a: OGMS:0000031 ! disease
property_value: IAO:0000118 "induced malaria" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/doid.owl

[Term]
id: DOID:12849
name: autistic disorder
def: "An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years." []
subset: https://www.fairsharing.org
is_a: DOID:0060037 ! developmental disorder of mental health
property_value: IAO:0000118 "autism" xsd:string
property_value: IAO:0000118 "autistic disorder of childhood onset" xsd:string
property_value: IAO:0000118 "childhood autism" xsd:string
property_value: IAO:0000118 "infantile autism" xsd:string
property_value: IAO:0000118 "Kanner's syndrome" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/doid.owl

[Term]
id: DOID:14330
name: Parkinson's disease
def: "A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions." []
subset: https://www.fairsharing.org
is_a: DOID:331 ! central nervous system disease
property_value: IAO:0000118 "paralysis agitans" xsd:string
property_value: IAO:0000118 "Parkinson disease" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/doid.owl

[Term]
id: DOID:150
name: disease of mental health
def: "A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture." []
is_a: OGMS:0000031 ! disease
property_value: IAO:0000412 http://purl.obolibrary.org/obo/doid.owl

[Term]
id: DOID:162
name: cancer
def: "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis." []
subset: https://www.fairsharing.org
is_a: OGMS:0000031 ! disease
property_value: IAO:0000118 "malignant neoplasm" xsd:string
property_value: IAO:0000118 "malignant tumor" xsd:string
property_value: IAO:0000118 "primary cancer" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/doid.owl

[Term]
id: DOID:1826
name: epilepsy
def: "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions." []
subset: https://www.fairsharing.org
is_a: DOID:331 ! central nervous system disease
property_value: IAO:0000118 "epilepsy syndrome" xsd:string
property_value: IAO:0000118 "epileptic syndrome" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/doid.owl

[Term]
id: DOID:302
name: substance abuse
def: "A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning." []
subset: https://www.fairsharing.org
is_a: DOID:150 ! disease of mental health
property_value: IAO:0000412 http://purl.obolibrary.org/obo/doid.owl

[Term]
id: DOID:331
name: central nervous system disease
def: "A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system." []
is_a: DOID:863 ! nervous system disease
property_value: IAO:0000412 http://purl.obolibrary.org/obo/doid.owl

[Term]
id: DOID:409
name: liver disease
subset: https://www.fairsharing.org
is_a: DOID:7 ! disease of anatomical entity
property_value: IAO:0000118 "disorder of liver" xsd:string
property_value: IAO:0000118 "hepatic disorder" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/doid.owl

[Term]
id: DOID:557
name: kidney disease
def: "A urinary system disease that is located_in the kidney." []
subset: https://www.fairsharing.org
is_a: DOID:7 ! disease of anatomical entity
property_value: IAO:0000118 "impaired renal function disease" xsd:string
property_value: IAO:0000118 "nephropathy" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/doid.owl

[Term]
id: DOID:7
name: disease of anatomical entity
def: "A disease that manifests in a defined anatomical structure." []
is_a: OGMS:0000031 ! disease
property_value: IAO:0000412 http://purl.obolibrary.org/obo/doid.owl

[Term]
id: DOID:863
name: nervous system disease
def: "A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system." []
is_a: OGMS:0000031 ! disease
property_value: IAO:0000412 http://purl.obolibrary.org/obo/doid.owl

[Term]
id: DOID:93
name: language disorder
def: "A communication disorder that involves the processing of linguistic information." []
subset: https://www.fairsharing.org
is_a: DOID:0060037 ! developmental disorder of mental health
property_value: IAO:0000412 http://purl.obolibrary.org/obo/doid.owl

[Term]
id: DRON:00000001
name: clinical drug role
def: "A role of a material entity to prevent, diagnose, treat, or study disease and/or its effects." []
is_a: BFO:0000023 ! role
property_value: IAO:0000412 http://purl.obolibrary.org/obo/dron.owl

[Term]
id: DRON:00000025
name: FDA approved drug role
def: "A drug role conferred by the United States Food and Drug Administration that permits the production, marketing, sale, prescribing, and consump- tion of its bearer in the United States." []
subset: https://www.fairsharing.org
is_a: drao:DRAO_0000322 ! Approved drug
property_value: drao:DRAO_0000001 "FDA approved drug" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/dron.owl

[Term]
id: ENVO:00000428
name: biome
def: "A biome is an ecosystem which is undergoing climactic ecological succession." []
is_a: ENVO:01000813 ! astronomical body part
is_a: ENVO:01001110 ! ecosystem
property_value: IAO:0000118 "major habitat type" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:00000447
name: marine biome
def: "A marine ecosystem which is in its climactic successional state." []
is_a: ENVO:00002030 ! aquatic biome
is_a: ENVO:01001788 ! marine ecosystem
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:00002030
name: aquatic biome
def: "A biome which is determined by a water body and which has ecological climax communities adapted to life in or on water." []
is_a: ENVO:00000428 ! biome
is_a: ENVO:01001787 ! aquatic ecosystem
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:00002034
name: biofilm
def: "A complex aggregation of microorganisms marked by the excretion of a protective and adhesive matrix; usually adhering to a substratum." []
subset: https://www.fairsharing.org
is_a: ENVO:01000549 ! mass of biological material
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:00010483
name: environmental material
def: "A material entity which other material entities in an environmental system are primarily or partially composed of." []
subset: https://www.fairsharing.org
is_a: BFO:0000040 ! material entity
property_value: IAO:0000118 "portion of environmental material" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01000024
name: marine benthic biome
def: "The marine benthic biome (benthic meaning 'bottom') encompasses the seafloor and includes such areas as shores, littoral or intertidal areas, marine coral reefs, and the deep seabed." []
is_a: ENVO:00000447 ! marine biome
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01000029
name: marine reef biome
def: "A biome expressed by strips or ridges of rocks, sand, or coral that rises to or near the surface of a body of marine water." []
is_a: ENVO:01000024 ! marine benthic biome
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01000049
name: marine coral reef biome
def: "The marine coral reef biome comprises constructional wave-resistant entities which are primarily built by corals and are often cemented together. The growth of these structures is aided by zooxanthellae, algae that are symbiotic with the reef-building corals." []
subset: https://www.fairsharing.org
is_a: ENVO:01000029 ! marine reef biome
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01000203
name: environmental condition
def: "An environmental condition is a range of a determinate quality or combination of qualities that are present in an environmental system." []
is_a: PATO:0001018 ! physical quality
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01000204
name: tropical
def: "A tropical condition is an environmental condition in which an environmental system receives high yearly solar irradiance per unit area and, on Earth, the Sun reaches a subsolar point at least once during the solar year. This results in a hot and moist year-round climate at low elevations, which have a monthly average temperature above 18 degrees Celsius." []
subset: https://www.fairsharing.org
is_a: ENVO:01000203 ! environmental condition
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01000254
name: environmental system
def: "A system which has the disposition to environ one or more material entities." []
is_a: RO:0002577 ! system
property_value: IAO:0000118 "environment" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01000320
name: marine environment
def: "An enviroment system which is determined by an ocean or sea." []
subset: https://www.fairsharing.org
is_a: ENVO:01000254 ! environmental system
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01000452
name: environmental disposition
def: "A disposition which is realised by an environmental system or system parts thereof." []
is_a: BFO:0000016 ! disposition
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01000549
name: mass of biological material
is_a: ENVO:01001691 ! mass of compounded environmental materials
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01000813
name: astronomical body part
def: "A material part of an astronomical body." []
is_a: BFO:0000040 ! material entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01000839
name: combustion process
def: "Combustion or burning is a high-temperature exothermic redox chemical reaction between a fuel and an oxidant that produces oxidized, often gaseous products, in a mixture termed as smoke." []
subset: https://www.fairsharing.org
is_a: ENVO:01000840 ! thermolysis
is_a: ENVO:01001654 ! aerosol formation process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01000840
name: thermolysis
def: "A chemical decomposition (the separation of a single chemical compound into its two or more elemental parts or to simpler compounds) caused by heat." []
is_a: ENVO:03000043 ! material transformation process
property_value: IAO:0000118 "thermal decomposition" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01001023
name: radiation
def: "A process during which energy is emitted or transmitted in the form of waves or particles through space or a material medium." []
subset: https://www.fairsharing.org
is_a: ENVO:01001852 ! energy transfer process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01001082
name: climate
def: "The disposition of an environmental system, particularly those influencing atmospheres, to manifest a cyclic pattern of weather over time." []
subset: https://www.fairsharing.org
is_a: ENVO:01000452 ! environmental disposition
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01001110
name: ecosystem
def: "An environmental system which includes both living and non-living components." []
subset: https://www.fairsharing.org
is_a: ENVO:01000254 ! environmental system
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01001654
name: aerosol formation process
def: "A material transformation process during which solid or liquid particles form and are suspended in a mass of air, thus creating an aerosol." []
is_a: ENVO:03000043 ! material transformation process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01001686
name: mass of environmental material
def: "An object which is composed primarily of an environmental material" []
is_a: BFO:0000030 ! object
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01001691
name: mass of compounded environmental materials
def: "An mass of environmental materials which has appreciable quantities of several individual materials, such that the removal of one would convert the mass into a different entity." []
is_a: ENVO:01001686 ! mass of environmental material
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01001787
name: aquatic ecosystem
def: "An ecosystem which has its functions and composition determined by a water body." []
is_a: ENVO:01000813 ! astronomical body part
is_a: ENVO:01001110 ! ecosystem
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01001788
name: marine ecosystem
is_a: ENVO:01000320 ! marine environment
is_a: ENVO:01001787 ! aquatic ecosystem
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:01001852
name: energy transfer process
def: "A process during which one entity loses energy to another entity." []
is_a: ENVO:02500000 ! environmental system process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:02500000
name: environmental system process
def: "A process in which includes the components of an environmental system as participants." []
is_a: BFO:0000015 ! process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: ENVO:03000043
name: material transformation process
def: "A process during which a portion of some environmental material is converted into a different material or a collection of materials." []
is_a: ENVO:02500000 ! environmental system process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: FBbi:00000267
name: animation
def: "A form of graphical illustration that changes with time to give a sense of motion or represent dynamic changes in the portrayal." []
subset: https://www.fairsharing.org
is_a: IAO:0000030 ! information content entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/fbbi.owl

[Term]
id: FBbi:00000364
name: light-sheet illumination
def: "illumination in the form of a thin sheet of light directed perpendicular to the optic axis" []
subset: https://www.fairsharing.org
is_a: CHMO:0000067 ! microscopy
property_value: IAO:0000412 http://purl.obolibrary.org/obo/fbbi.owl

[Term]
id: FBcv:0000155
name: single balancer
def: "Chromosome that carries inversions and visible mutations, and which can be used to identify the genotype of an individual." []
subset: https://www.fairsharing.org
is_a: CHEBI:24432 ! biological role
property_value: IAO:0000412 http://purl.obolibrary.org/obo/dpo.owl

[Term]
id: FBcv:0000623
name: enhancer
def: "Genotype g1 is enhancer of genotype g2 if (and only if) the phenotype due to the genotype g1g2 is more severe than the sum of phenotypes due to g1 and g2, where all comparisons are under identical environmental conditions." []
subset: https://www.fairsharing.org
is_a: CHEBI:24432 ! biological role
property_value: IAO:0000412 http://purl.obolibrary.org/obo/dpo.owl

[Term]
id: FBcv:0003035
name: proteome
def: "A project that characterizes the set of proteins expressed in an organism." []
subset: https://www.fairsharing.org
is_a: SO:0001260 ! sequence_collection
property_value: IAO:0000412 http://purl.obolibrary.org/obo/dpo.owl

[Term]
id: FBcv:0003036
name: interactome
def: "A project that characterizes the set of inter-molecular interactions in an organism." []
subset: https://www.fairsharing.org
is_a: IAO:0000030 ! information content entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/dpo.owl

[Term]
id: FBcv:0003039
name: chemical screen
def: "A project that searches for chemicals, natural or synthetic, that elicit some biological effect." []
subset: https://www.fairsharing.org
is_a: efo:EFO_0007550 ! high content screen
property_value: IAO:0000412 http://purl.obolibrary.org/obo/dpo.owl

[Term]
id: FBcv:0003040
name: gene model annotation
def: "A project that constructs models describing the set of transcripts and polypeptides encoded by some group of genes." []
subset: https://www.fairsharing.org
is_a: OBI:0200000 ! data transformation
property_value: IAO:0000412 http://purl.obolibrary.org/obo/dpo.owl

[Term]
id: FBcv:0003077
name: RNAi screen
def: "An assay that uses a panel of RNA interference (RNAi) reagents to systematically knockdown a large set of genes, one at a time, to identify those that are involved in some biological process." []
subset: https://www.fairsharing.org
is_a: OBI:0000070 ! assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/dpo.owl

[Term]
id: FBcv:0003195
name: CAGE
def: "Material that has been selected using Cap Analysis Gene Expression, in which the 7-methylguanosine cap at 5' transcript ends is biotinylated and affinity purified." []
subset: https://www.fairsharing.org
is_a: OBI:0000070 ! assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/dpo.owl

[Term]
id: FMA:70631
name: Cell morphology
subset: https://www.fairsharing.org
is_a: PATO:0000051 ! morphology
property_value: IAO:0000412 http://purl.obolibrary.org/obo/fma.owl

[Term]
id: FMA:84795
name: Human leukocyte antigen complex
subset: https://www.fairsharing.org
is_a: GO:0032991 ! protein-containing complex
property_value: IAO:0000118 "HLA" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/fma.owl

[Term]
id: GO:0000380
name: alternative mRNA splicing, via spliceosome
def: "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." []
subset: https://www.fairsharing.org
is_a: GO:0000398 ! mRNA splicing, via spliceosome
property_value: IAO:0000118 "alternative nuclear mRNA splicing, via spliceosome" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0000398
name: mRNA splicing, via spliceosome
def: "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." []
is_a: GO:0006397 ! mRNA processing
is_a: GO:0008380 ! RNA splicing
property_value: IAO:0000118 "nuclear mRNA splicing via U12-type spliceosome" xsd:string
property_value: IAO:0000118 "nuclear mRNA splicing via U2-type spliceosome" xsd:string
property_value: IAO:0000118 "nuclear mRNA splicing, via spliceosome" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0000775
name: chromosome, centromeric region
def: "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." []
subset: https://www.fairsharing.org
is_a: GO:0098687 ! chromosomal region
property_value: IAO:0000118 "centromere complex" xsd:string
property_value: IAO:0000118 "chromosome, centric region" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0003674
name: molecular_function
def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." []
subset: https://www.fairsharing.org
is_a: BFO:0000034 ! function
property_value: IAO:0000118 "molecular function" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0003682
name: chromatin binding
def: "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." []
subset: https://www.fairsharing.org
is_a: GO:0005488 ! binding
property_value: IAO:0000118 "lamin/chromatin binding" xsd:string
property_value: IAO:0000118 "microtubule/chromatin interaction" xsd:string
property_value: IAO:0000118 "nuclear membrane vesicle binding to chromatin" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0003824
name: catalytic activity
def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." []
subset: https://www.fairsharing.org
is_a: GO:0003674 ! molecular_function
property_value: IAO:0000118 "enzyme activity" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0005216
name: monoatomic ion channel activity
def: "Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." []
subset: https://www.fairsharing.org
is_a: GO:0003674 ! molecular_function
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0005488
name: binding
def: "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." []
subset: https://www.fairsharing.org
is_a: GO:0003674 ! molecular_function
property_value: IAO:0000118 "ligand" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0005515
name: protein binding
def: "Binding to a protein." []
subset: https://www.fairsharing.org
is_a: GO:0005488 ! binding
property_value: IAO:0000118 "glycoprotein binding" xsd:string
property_value: IAO:0000118 "protein amino acid binding" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0005575
name: cellular_component
def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex)." []
subset: https://www.fairsharing.org
is_a: OBI:0100051 ! specimen
property_value: IAO:0000118 "cell or subcellular entity" xsd:string
property_value: IAO:0000118 "cellular component" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0005622
name: intracellular anatomical structure
def: "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." []
is_a: GO:0110165 ! cellular anatomical structure
property_value: IAO:0000118 "internal to cell" xsd:string
property_value: IAO:0000118 "intracellular" xsd:string
property_value: IAO:0000118 "protoplasm" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0005634
name: nucleus
def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." []
subset: https://www.fairsharing.org
is_a: GO:0043231 ! intracellular membrane-bounded organelle
property_value: IAO:0000118 "cell nucleus" xsd:string
property_value: IAO:0000118 "horsetail nucleus" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0005694
name: chromosome
def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." []
subset: https://www.fairsharing.org
is_a: GO:0043232 ! intracellular membraneless organelle
property_value: IAO:0000118 "interphase chromosome" xsd:string
property_value: IAO:0000118 "prophase chromosome" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0005739
name: mitochondrion
def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." []
subset: https://www.fairsharing.org
is_a: GO:0043231 ! intracellular membrane-bounded organelle
property_value: IAO:0000118 "mitochondria" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0005813
name: centrosome
def: "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." []
subset: https://www.fairsharing.org
is_a: GO:0110165 ! cellular anatomical structure
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0005996
name: monosaccharide metabolic process
def: "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." []
is_a: GO:0044238 ! primary metabolic process
property_value: IAO:0000118 "monosaccharide metabolism" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0006006
name: glucose metabolic process
def: "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." []
subset: https://www.fairsharing.org
is_a: GO:0005996 ! monosaccharide metabolic process
property_value: IAO:0000118 "cellular glucose metabolic process" xsd:string
property_value: IAO:0000118 "glucose metabolism" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0006338
name: chromatin remodeling
def: "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." []
subset: https://www.fairsharing.org
is_a: GO:0016043 ! cellular component organization
property_value: IAO:0000118 "ATP-dependent chromatin remodeling" xsd:string
property_value: IAO:0000118 "ATP-dependent chromatin remodelling" xsd:string
property_value: IAO:0000118 "chromatin modeling" xsd:string
property_value: IAO:0000118 "chromatin modelling" xsd:string
property_value: IAO:0000118 "chromatin remodelling" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0006396
name: RNA processing
def: "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." []
is_a: GO:0044238 ! primary metabolic process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0006397
name: mRNA processing
def: "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." []
is_a: GO:0006396 ! RNA processing
is_a: GO:0016070 ! RNA metabolic process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0006412
name: translation
def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." []
subset: https://www.fairsharing.org
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0019538 ! protein metabolic process
property_value: IAO:0000118 "protein anabolism" xsd:string
property_value: IAO:0000118 "protein biosynthesis" xsd:string
property_value: IAO:0000118 "protein biosynthetic process" xsd:string
property_value: IAO:0000118 "protein formation" xsd:string
property_value: IAO:0000118 "protein synthesis" xsd:string
property_value: IAO:0000118 "protein translation" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0006413
name: translational initiation
def: "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." []
subset: https://www.fairsharing.org
is_a: GO:0008152 ! metabolic process
property_value: IAO:0000118 "translation initiation" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0006457
name: protein folding
def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." []
subset: https://www.fairsharing.org
is_a: GO:0009987 ! cellular process
property_value: IAO:0000118 "alpha-tubulin folding" xsd:string
property_value: IAO:0000118 "beta-tubulin folding" xsd:string
property_value: IAO:0000118 "chaperonin-mediated tubulin folding" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0006473
name: protein acetylation
def: "The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." []
subset: https://www.fairsharing.org
is_a: GO:0036211 ! protein modification process
property_value: IAO:0000118 "protein amino acid acetylation" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0006605
name: protein targeting
def: "The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." []
subset: https://www.fairsharing.org
is_a: GO:0045184 ! establishment of protein localization
property_value: IAO:0000118 "protein sorting along secretory pathway" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0006805
name: xenobiotic metabolic process
def: "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." []
subset: https://www.fairsharing.org
is_a: GO:0008152 ! metabolic process
property_value: IAO:0000118 "xenobiotic metabolism" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0006810
name: transport
def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." []
subset: https://www.fairsharing.org
is_a: GO:0051234 ! establishment of localization
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0006954
name: inflammatory response
def: "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." []
subset: https://www.fairsharing.org
is_a: GO:0008150 ! biological_process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0007049
name: cell cycle
def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." []
subset: https://www.fairsharing.org
is_a: GO:0009987 ! cellular process
property_value: IAO:0000118 "cell-division cycle" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0007127
name: meiosis I
def: "The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei." []
subset: https://www.fairsharing.org
is_a: GO:0140013 ! meiotic nuclear division
property_value: IAO:0000118 "meiosis I nuclear division" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0007135
name: meiosis II
def: "The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II." []
subset: https://www.fairsharing.org
is_a: GO:0140013 ! meiotic nuclear division
property_value: IAO:0000118 "meiosis II nuclear division" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0007155
name: cell adhesion
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." []
subset: https://www.fairsharing.org
is_a: GO:0009987 ! cellular process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0007606
name: sensory perception of chemical stimulus
def: "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." []
is_a: GO:0050877 ! nervous system process
property_value: IAO:0000118 "chemosensory perception" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0007608
name: sensory perception of smell
def: "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." []
subset: https://www.fairsharing.org
is_a: GO:0007606 ! sensory perception of chemical stimulus
property_value: IAO:0000118 "olfaction" xsd:string
property_value: IAO:0000118 "scent perception" xsd:string
property_value: IAO:0000118 "sense of smell" xsd:string
property_value: IAO:0000118 "smell perception" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0007610
name: behavior
def: "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." []
subset: https://www.fairsharing.org
is_a: GO:0032501 ! multicellular organismal process
property_value: IAO:0000118 "behavioral response to stimulus" xsd:string
property_value: IAO:0000118 "behaviour" xsd:string
property_value: IAO:0000118 "behavioural response to stimulus" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0008104
name: protein localization
def: "Any process in which a protein is transported to, or maintained in, a specific location." []
subset: https://www.fairsharing.org
is_a: GO:0070727 ! cellular macromolecule localization
property_value: IAO:0000118 "cellular protein localisation" xsd:string
property_value: IAO:0000118 "cellular protein localization" xsd:string
property_value: IAO:0000118 "channel localizer activity" xsd:string
property_value: IAO:0000118 "protein localisation" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0008150
name: biological_process
def: "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." []
subset: https://www.fairsharing.org
is_a: BFO:0000015 ! process
property_value: IAO:0000118 "biological process" xsd:string
property_value: IAO:0000118 "physiological process" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: GO:0008152
name: metabolic process
def: "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well  macromolecular processes such as DNA repair and replication, protein synthesis and degradation." []
is_a: GO:0009987 ! cellular process
property_value: IAO:0000118 "metabolism" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0008380
name: RNA splicing
def: "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." []
subset: https://www.fairsharing.org
is_a: GO:0006396 ! RNA processing
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0009058
name: biosynthetic process
def: "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." []
is_a: GO:0008152 ! metabolic process
property_value: IAO:0000118 "anabolism" xsd:string
property_value: IAO:0000118 "biosynthesis" xsd:string
property_value: IAO:0000118 "multicellular organismal biosynthetic process" xsd:string
property_value: IAO:0000118 "synthesis" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0009059
name: macromolecule biosynthetic process
def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0043170 ! macromolecule metabolic process
property_value: IAO:0000118 "biopolymer biosynthetic process" xsd:string
property_value: IAO:0000118 "macromolecule anabolism" xsd:string
property_value: IAO:0000118 "macromolecule biosynthesis" xsd:string
property_value: IAO:0000118 "macromolecule formation" xsd:string
property_value: IAO:0000118 "macromolecule synthesis" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0009306
name: protein secretion
def: "The controlled release of proteins from a cell." []
subset: https://www.fairsharing.org
is_a: GO:0015031 ! protein transport
is_a: GO:0032940 ! secretion by cell
is_a: GO:0035592 ! establishment of protein localization to extracellular region
property_value: IAO:0000118 "glycoprotein secretion" xsd:string
property_value: IAO:0000118 "protein secretion during cell fate commitment" xsd:string
property_value: IAO:0000118 "protein secretion resulting in cell fate commitment" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0009451
name: RNA modification
def: "The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." []
subset: https://www.fairsharing.org
is_a: GO:0016070 ! RNA metabolic process
is_a: GO:0043412 ! macromolecule modification
property_value: IAO:0000118 "RNA editing" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0009536
name: plastid
def: "Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." []
subset: https://www.fairsharing.org
is_a: GO:0043231 ! intracellular membrane-bounded organelle
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0009889
name: regulation of biosynthetic process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." []
is_a: GO:0019222 ! regulation of metabolic process
property_value: IAO:0000118 "regulation of anabolism" xsd:string
property_value: IAO:0000118 "regulation of biosynthesis" xsd:string
property_value: IAO:0000118 "regulation of formation" xsd:string
property_value: IAO:0000118 "regulation of synthesis" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0009890
name: negative regulation of biosynthetic process
def: "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0009892 ! negative regulation of metabolic process
property_value: IAO:0000118 "down regulation of biosynthetic process" xsd:string
property_value: IAO:0000118 "down-regulation of biosynthetic process" xsd:string
property_value: IAO:0000118 "downregulation of biosynthetic process" xsd:string
property_value: IAO:0000118 "inhibition of biosynthetic process" xsd:string
property_value: IAO:0000118 "negative regulation of anabolism" xsd:string
property_value: IAO:0000118 "negative regulation of biosynthesis" xsd:string
property_value: IAO:0000118 "negative regulation of formation" xsd:string
property_value: IAO:0000118 "negative regulation of synthesis" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0009892
name: negative regulation of metabolic process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." []
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0048523 ! negative regulation of cellular process
property_value: IAO:0000118 "down regulation of metabolic process" xsd:string
property_value: IAO:0000118 "down-regulation of metabolic process" xsd:string
property_value: IAO:0000118 "downregulation of metabolic process" xsd:string
property_value: IAO:0000118 "inhibition of metabolic process" xsd:string
property_value: IAO:0000118 "inhibition of organismal metabolic process" xsd:string
property_value: IAO:0000118 "negative regulation of metabolism" xsd:string
property_value: IAO:0000118 "negative regulation of multicellular organismal metabolic process" xsd:string
property_value: IAO:0000118 "negative regulation of organismal metabolism" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0009987
name: cellular process
def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." []
is_a: GO:0008150 ! biological_process
property_value: IAO:0000118 "cell growth and/or maintenance" xsd:string
property_value: IAO:0000118 "cell physiology" xsd:string
property_value: IAO:0000118 "cellular physiological process" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0010467
name: gene expression
def: "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." []
subset: https://www.fairsharing.org
is_a: GO:0009059 ! macromolecule biosynthetic process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0010468
name: regulation of gene expression
def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." []
subset: https://www.fairsharing.org
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
property_value: IAO:0000118 "regulation of protein expression" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0010556
name: regulation of macromolecule biosynthetic process
def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0010558
name: negative regulation of macromolecule biosynthetic process
def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." []
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0010605
name: negative regulation of macromolecule metabolic process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0010629
name: negative regulation of gene expression
def: "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." []
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0015031
name: protein transport
def: "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." []
is_a: GO:0006810 ! transport
is_a: GO:0045184 ! establishment of protein localization
property_value: IAO:0000118 "enzyme transport" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0016043
name: cellular component organization
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." []
is_a: GO:0009987 ! cellular process
property_value: IAO:0000118 "cell organisation" xsd:string
property_value: IAO:0000118 "cellular component organisation at cellular level" xsd:string
property_value: IAO:0000118 "cellular component organisation in other organism" xsd:string
property_value: IAO:0000118 "cellular component organization at cellular level" xsd:string
property_value: IAO:0000118 "cellular component organization in other organism" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0016070
name: RNA metabolic process
def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." []
is_a: GO:0090304 ! nucleic acid metabolic process
property_value: IAO:0000118 "RNA metabolism" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0016310
name: phosphorylation
def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." []
subset: https://www.fairsharing.org
is_a: GO:0008152 ! metabolic process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0016441
name: post-transcriptional gene silencing
def: "The inactivation of gene expression that occurs after transcription." []
is_a: GO:0010629 ! negative regulation of gene expression
property_value: IAO:0000118 "posttranscriptional gene silencing" xsd:string
property_value: IAO:0000118 "PTGS" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0016477
name: cell migration
def: "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." []
subset: https://www.fairsharing.org
is_a: GO:0009987 ! cellular process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0019222
name: regulation of metabolic process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." []
is_a: GO:0050794 ! regulation of cellular process
property_value: IAO:0000118 "regulation of metabolism" xsd:string
property_value: IAO:0000118 "regulation of multicellular organismal metabolic process" xsd:string
property_value: IAO:0000118 "regulation of organismal metabolic process" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0019538
name: protein metabolic process
def: "The chemical reactions and pathways involving a protein. Includes protein modification." []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0044238 ! primary metabolic process
property_value: IAO:0000118 "cellular protein metabolic process" xsd:string
property_value: IAO:0000118 "cellular protein metabolism" xsd:string
property_value: IAO:0000118 "multicellular organismal protein metabolic process" xsd:string
property_value: IAO:0000118 "protein metabolic process and modification" xsd:string
property_value: IAO:0000118 "protein metabolism" xsd:string
property_value: IAO:0000118 "protein metabolism and modification" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0019814
name: immunoglobulin complex
def: "A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." []
subset: https://www.fairsharing.org
is_a: GO:0032991 ! protein-containing complex
property_value: IAO:0000118 "antibody" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0019815
name: B cell receptor complex
def: "An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." []
subset: https://www.fairsharing.org
is_a: GO:0019814 ! immunoglobulin complex
is_a: GO:0098802 ! plasma membrane signaling receptor complex
property_value: IAO:0000118 "B lymphocyte receptor complex" xsd:string
property_value: IAO:0000118 "B-cell receptor complex" xsd:string
property_value: IAO:0000118 "B-lymphocyte receptor complex" xsd:string
property_value: IAO:0000118 "BCR complex" xsd:string
property_value: IAO:0000118 "immunoglobulin complex, membrane bound" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0023052
name: signaling
def: "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." []
subset: https://www.fairsharing.org
is_a: GO:0050789 ! regulation of biological process
property_value: IAO:0000118 "biological signaling" xsd:string
property_value: IAO:0000118 "signaling process" xsd:string
property_value: IAO:0000118 "signalling" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0030097
name: hemopoiesis
def: "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." []
subset: https://www.fairsharing.org
is_a: GO:0048468 ! cell development
property_value: IAO:0000118 "blood cell biosynthesis" xsd:string
property_value: IAO:0000118 "blood cell formation" xsd:string
property_value: IAO:0000118 "haemopoiesis" xsd:string
property_value: IAO:0000118 "hematopoiesis" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0030431
name: sleep
def: "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." []
subset: https://www.fairsharing.org
is_a: GO:0032501 ! multicellular organismal process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0031982
name: vesicle
def: "Any small, fluid-filled, spherical organelle enclosed by membrane." []
subset: https://www.fairsharing.org
is_a: GO:0043227 ! membrane-bounded organelle
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0032259
name: methylation
def: "The process in which a methyl group is covalently attached to a molecule." []
subset: https://www.fairsharing.org
is_a: GO:0008152 ! metabolic process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0032501
name: multicellular organismal process
def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." []
is_a: GO:0008150 ! biological_process
property_value: IAO:0000118 "organismal physiological process" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0032502
name: developmental process
def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." []
is_a: GO:0008150 ! biological_process
property_value: IAO:0000118 "development" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0032940
name: secretion by cell
def: "The controlled release of a substance by a cell." []
is_a: GO:0140352 ! export from cell
property_value: IAO:0000118 "cellular secretion" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0032991
name: protein-containing complex
def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." []
subset: https://www.fairsharing.org
is_a: GO:0005575 ! cellular_component
property_value: IAO:0000118 "macromolecular complex" xsd:string
property_value: IAO:0000118 "macromolecule complex" xsd:string
property_value: IAO:0000118 "protein complex" xsd:string
property_value: IAO:0000118 "protein containing complex" xsd:string
property_value: IAO:0000118 "protein-protein complex" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0035194
name: regulatory ncRNA-mediated post-transcriptional gene silencing
def: "A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation." []
subset: https://www.fairsharing.org
is_a: GO:0016441 ! post-transcriptional gene silencing
property_value: IAO:0000118 "ncRNA-mediated post-transcriptional gene silencing" xsd:string
property_value: IAO:0000118 "posttranscriptional gene silencing by RNA" xsd:string
property_value: IAO:0000118 "RNA-dependent post-transcriptional gene silencing" xsd:string
property_value: IAO:0000118 "RNA-mediated post-transcriptional gene silencing" xsd:string
property_value: IAO:0000118 "RNA-mediated posttranscriptional gene silencing" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0035195
name: miRNA-mediated post-transcriptional gene silencing
def: "A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants." []
subset: https://www.fairsharing.org
is_a: GO:0035194 ! regulatory ncRNA-mediated post-transcriptional gene silencing
property_value: IAO:0000118 "gene silencing by microRNA" xsd:string
property_value: IAO:0000118 "gene silencing by miRNA" xsd:string
property_value: IAO:0000118 "microRNA-mediated gene silencing" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0035592
name: establishment of protein localization to extracellular region
def: "The directed movement of a protein to a specific location within the extracellular region." []
is_a: GO:0045184 ! establishment of protein localization
property_value: IAO:0000118 "establishment of protein localisation in extracellular region" xsd:string
property_value: IAO:0000118 "establishment of protein localization in extracellular region" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0036094
name: small molecule binding
def: "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." []
subset: https://www.fairsharing.org
is_a: GO:0005488 ! binding
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0036211
name: protein modification process
def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." []
subset: https://www.fairsharing.org
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0043412 ! macromolecule modification
property_value: IAO:0000118 "cellular protein modification process" xsd:string
property_value: IAO:0000118 "process resulting in protein modification" xsd:string
property_value: IAO:0000118 "protein modification" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0042101
name: T cell receptor complex
def: "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains." []
subset: https://www.fairsharing.org
is_a: GO:0098802 ! plasma membrane signaling receptor complex
property_value: IAO:0000118 "T lymphocyte receptor complex" xsd:string
property_value: IAO:0000118 "T-cell receptor complex" xsd:string
property_value: IAO:0000118 "T-lymphocyte receptor complex" xsd:string
property_value: IAO:0000118 "TCR complex" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0042571
name: immunoglobulin complex, circulating
def: "An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component." []
subset: https://www.fairsharing.org
is_a: GO:0019814 ! immunoglobulin complex
property_value: IAO:0000118 "antibody" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0043043
name: peptide biosynthetic process
def: "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." []
is_a: GO:0009058 ! biosynthetic process
property_value: IAO:0000118 "peptide anabolism" xsd:string
property_value: IAO:0000118 "peptide biosynthesis" xsd:string
property_value: IAO:0000118 "peptide formation" xsd:string
property_value: IAO:0000118 "peptide synthesis" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0043170
name: macromolecule metabolic process
def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." []
is_a: GO:0008152 ! metabolic process
property_value: IAO:0000118 "biopolymer metabolic process" xsd:string
property_value: IAO:0000118 "macromolecule metabolism" xsd:string
property_value: IAO:0000118 "multicellular organismal macromolecule metabolic process" xsd:string
property_value: IAO:0000118 "organismal macromolecule metabolism" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0043226
name: organelle
def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." []
subset: https://www.fairsharing.org
is_a: GO:0110165 ! cellular anatomical structure
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0043227
name: membrane-bounded organelle
def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." []
is_a: GO:0043226 ! organelle
property_value: IAO:0000118 "membrane-enclosed organelle" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0043229
name: intracellular organelle
def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." []
is_a: GO:0043226 ! organelle
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0043231
name: intracellular membrane-bounded organelle
def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." []
is_a: GO:0043227 ! membrane-bounded organelle
is_a: GO:0043229 ! intracellular organelle
property_value: IAO:0000118 "intracellular membrane-enclosed organelle" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0043232
name: intracellular membraneless organelle
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." []
is_a: GO:0043229 ! intracellular organelle
property_value: IAO:0000118 "intracellular non-membrane-bounded organelle" xsd:string
property_value: IAO:0000118 "intracellular non-membrane-enclosed organelle" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0043412
name: macromolecule modification
def: "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." []
is_a: GO:0043170 ! macromolecule metabolic process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0043687
name: post-translational protein modification
def: "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." []
subset: https://www.fairsharing.org
is_a: GO:0036211 ! protein modification process
property_value: IAO:0000118 "post-translational amino acid modification" xsd:string
property_value: IAO:0000118 "post-translational modification" xsd:string
property_value: IAO:0000118 "posttranslational amino acid modification" xsd:string
property_value: IAO:0000118 "posttranslational modification" xsd:string
property_value: IAO:0000118 "posttranslational protein modification" xsd:string
property_value: IAO:0000118 "PTM" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0044238
name: primary metabolic process
def: "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." []
is_a: GO:0008152 ! metabolic process
property_value: IAO:0000118 "primary metabolism" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0045184
name: establishment of protein localization
def: "The directed movement of a protein to a specific location." []
is_a: GO:0008104 ! protein localization
is_a: GO:0051234 ! establishment of localization
property_value: IAO:0000118 "establishment of protein localisation" xsd:string
property_value: IAO:0000118 "protein positioning" xsd:string
property_value: IAO:0000118 "protein recruitment" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0046872
name: metal ion binding
def: "Binding to a metal ion." []
subset: https://www.fairsharing.org
is_a: GO:0036094 ! small molecule binding
property_value: IAO:0000118 "heavy metal binding" xsd:string
property_value: IAO:0000118 "metal binding" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0048468
name: cell development
def: "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." []
is_a: GO:0048856 ! anatomical structure development
is_a: GO:0048869 ! cellular developmental process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0048513
name: animal organ development
def: "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." []
subset: https://www.fairsharing.org
is_a: GO:0048856 ! anatomical structure development
property_value: IAO:0000118 "development of an organ" xsd:string
property_value: IAO:0000118 "organogenesis" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0048523
name: negative regulation of cellular process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." []
is_a: GO:0050794 ! regulation of cellular process
property_value: IAO:0000118 "down regulation of cellular process" xsd:string
property_value: IAO:0000118 "down-regulation of cellular process" xsd:string
property_value: IAO:0000118 "downregulation of cellular process" xsd:string
property_value: IAO:0000118 "inhibition of cellular process" xsd:string
property_value: IAO:0000118 "negative regulation of cellular physiological process" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0048856
name: anatomical structure development
def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." []
is_a: GO:0032502 ! developmental process
property_value: IAO:0000118 "development of an anatomical structure" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0048869
name: cellular developmental process
def: "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." []
is_a: GO:0009987 ! cellular process
is_a: GO:0032502 ! developmental process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0050693
name: LBD domain binding
def: "Binding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket." []
subset: https://www.fairsharing.org
is_a: GO:0005515 ! protein binding
property_value: IAO:0000118 "ligand binding domain binding" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0050789
name: regulation of biological process
def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." []
is_a: GO:0065007 ! biological regulation
property_value: IAO:0000118 "regulation of physiological process" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0050794
name: regulation of cellular process
def: "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." []
is_a: GO:0050789 ! regulation of biological process
property_value: IAO:0000118 "regulation of cellular physiological process" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0050877
name: nervous system process
def: "An organ system process carried out by any of the organs or tissues of the neurological system." []
is_a: GO:0032501 ! multicellular organismal process
property_value: IAO:0000118 "neurological system process" xsd:string
property_value: IAO:0000118 "neurophysiological process" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0050890
name: cognition
def: "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." []
subset: https://www.fairsharing.org
is_a: GO:0050877 ! nervous system process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0050909
name: sensory perception of taste
def: "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." []
subset: https://www.fairsharing.org
is_a: GO:0007606 ! sensory perception of chemical stimulus
property_value: IAO:0000118 "gustation" xsd:string
property_value: IAO:0000118 "sense of taste" xsd:string
property_value: IAO:0000118 "taste" xsd:string
property_value: IAO:0000118 "taste perception" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0051087
name: protein-folding chaperone binding
def: "Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." []
subset: https://www.fairsharing.org
is_a: GO:0005515 ! protein binding
property_value: IAO:0000118 "chaperone protein binding" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0051179
name: localization
def: "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." []
is_a: GO:0008150 ! biological_process
property_value: IAO:0000118 "establishment and maintenance of cellular component location" xsd:string
property_value: IAO:0000118 "establishment and maintenance of localization" xsd:string
property_value: IAO:0000118 "establishment and maintenance of position" xsd:string
property_value: IAO:0000118 "establishment and maintenance of substance location" xsd:string
property_value: IAO:0000118 "establishment and maintenance of substrate location" xsd:string
property_value: IAO:0000118 "localisation" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0051234
name: establishment of localization
def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." []
is_a: GO:0051179 ! localization
property_value: IAO:0000118 "establishment of localisation" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0051246
name: regulation of protein metabolic process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." []
is_a: GO:0060255 ! regulation of macromolecule metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
property_value: IAO:0000118 "regulation of protein metabolism" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0051252
name: regulation of RNA metabolic process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." []
is_a: GO:0060255 ! regulation of macromolecule metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
property_value: IAO:0000118 "regulation of RNA metabolism" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0051301
name: cell division
def: "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." []
subset: https://www.fairsharing.org
is_a: GO:0009987 ! cellular process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0051641
name: cellular localization
def: "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." []
subset: https://www.fairsharing.org
is_a: GO:0009987 ! cellular process
is_a: GO:0051179 ! localization
property_value: IAO:0000118 "cellular localisation" xsd:string
property_value: IAO:0000118 "establishment and maintenance of cellular localization" xsd:string
property_value: IAO:0000118 "establishment and maintenance of localization in cell or cell membrane" xsd:string
property_value: IAO:0000118 "intracellular localization" xsd:string
property_value: IAO:0000118 "localization within cell" xsd:string
property_value: IAO:0000118 "single organism cellular localization" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0060255
name: regulation of macromolecule metabolic process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." []
is_a: GO:0019222 ! regulation of metabolic process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0060293
name: germ plasm
def: "Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line." []
subset: https://www.fairsharing.org
is_a: GO:0110165 ! cellular anatomical structure
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0065007
name: biological regulation
def: "Any process that modulates a measurable attribute of any biological process, quality or function." []
subset: https://www.fairsharing.org
is_a: GO:0008150 ! biological_process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0065010
name: extracellular membrane-bounded organelle
def: "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." []
is_a: GO:0043227 ! membrane-bounded organelle
property_value: IAO:0000118 "extracellular membrane-enclosed organelle" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0070062
name: extracellular exosome
def: "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." []
subset: https://www.fairsharing.org
is_a: GO:1903561 ! extracellular vesicle
property_value: IAO:0000118 "exosome" xsd:string
property_value: IAO:0000118 "extracellular vesicular exosome" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0070085
name: glycosylation
def: "The covalent attachment and further modification of carbohydrate residues to a substrate molecule." []
subset: https://www.fairsharing.org
is_a: GO:0008152 ! metabolic process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0070727
name: cellular macromolecule localization
def: "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." []
is_a: GO:0051641 ! cellular localization
property_value: IAO:0000118 "cellular macromolecule localisation" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0080090
name: regulation of primary metabolic process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." []
is_a: GO:0019222 ! regulation of metabolic process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0090304
name: nucleic acid metabolic process
def: "Any cellular metabolic process involving nucleic acids." []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0044238 ! primary metabolic process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0098687
name: chromosomal region
def: "Any subdivision of a chromosome along its length." []
subset: https://www.fairsharing.org
is_a: GO:0110165 ! cellular anatomical structure
property_value: IAO:0000118 "chromosome region" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0098802
name: plasma membrane signaling receptor complex
def: "Any protein complex that is part of the plasma membrane and which functions as a signaling receptor." []
is_a: GO:0032991 ! protein-containing complex
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0110165
name: cellular anatomical structure
def: "A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses." []
is_a: GO:0005575 ! cellular_component
property_value: IAO:0000118 "cellular anatomical entity" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0140013
name: meiotic nuclear division
def: "One of the two nuclear divisions that occur as part of the meiotic cell cycle." []
is_a: GO:0016043 ! cellular component organization
is_a: GO:1903046 ! meiotic cell cycle process
property_value: IAO:0000118 "meiosis" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:0140352
name: export from cell
def: "The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis." []
is_a: GO:0006810 ! transport
is_a: GO:0009987 ! cellular process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:1901873
name: regulation of post-translational protein modification
def: "Any process that modulates the frequency, rate or extent of post-translational protein modification." []
subset: https://www.fairsharing.org
is_a: GO:0051246 ! regulation of protein metabolic process
property_value: IAO:0000118 "regulation of post-translational amino acid modification" xsd:string
property_value: IAO:0000118 "regulation of post-translational modification" xsd:string
property_value: IAO:0000118 "regulation of posttranslational amino acid modification" xsd:string
property_value: IAO:0000118 "regulation of posttranslational modification" xsd:string
property_value: IAO:0000118 "regulation of posttranslational protein modification" xsd:string
property_value: IAO:0000118 "regulation of PTM" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:1903046
name: meiotic cell cycle process
def: "A process that is part of the meiotic cell cycle." []
is_a: GO:0009987 ! cellular process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:1903561
name: extracellular vesicle
def: "Any vesicle that is part of the extracellular region." []
is_a: GO:0031982 ! vesicle
is_a: GO:0065010 ! extracellular membrane-bounded organelle
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: GO:2000628
name: regulation of miRNA metabolic process
def: "Any process that modulates the frequency, rate or extent of miRNA metabolic process." []
subset: https://www.fairsharing.org
is_a: GO:0051252 ! regulation of RNA metabolic process
property_value: IAO:0000118 "regulation of microRNA metabolic process" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl

[Term]
id: HP:0001428
name: obsolete Somatic mutation
subset: https://www.fairsharing.org
is_a: OGMS:0000031 ! disease
property_value: IAO:0000412 http://purl.obolibrary.org/obo/hp.owl

[Term]
id: HP:0002664
name: Neoplasm
def: "An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor)." []
subset: https://www.fairsharing.org
is_a: OGMS:0000023 ! phenotype
property_value: IAO:0000118 "Neoplasia" xsd:string
property_value: IAO:0000118 "Oncological abnormality" xsd:string
property_value: IAO:0000118 "Tumor" xsd:string
property_value: IAO:0000118 "Tumour" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/hp.owl

[Term]
id: HP:0010984
name: Digenic inheritance
def: "A type of multifactorial inheritance governed by the simultaneous action of two gene loci." []
subset: https://www.fairsharing.org
is_a: BFO:0000016 ! disposition
property_value: IAO:0000412 http://purl.obolibrary.org/obo/hp.owl

[Term]
id: IAO:0000027
name: data item
def: "An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements." []
is_a: IAO:0000030 ! information content entity
property_value: IAO:0000118 "data" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obcs.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/stato.owl

[Term]
id: IAO:0000030
name: information content entity
def: "A generically dependent continuant that is about some thing." []
is_a: BFO:0000031 ! generically dependent continuant
property_value: IAO:0000118 "information content entity" xsd:string
property_value: IAO:0000412 efo:efo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obcs.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/stato.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/swo.owl

[Term]
id: IAO:0000033
name: directive information entity
def: "An information content entity whose concretizations indicate to their bearer how to realize them in a process." []
is_a: IAO:0000030 ! information content entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: IAO:0000038
name: graph
def: "A diagram that presents one or more tuples of information by mapping those tuples in to a two dimensional space in a non arbitrary way." []
subset: https://www.fairsharing.org
is_a: IAO:0000309 ! diagram
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl

[Term]
id: IAO:0000064
name: algorithm
def: "A plan specification which describes the inputs and output of mathematical functions as well as workflow of execution for achieving an predefined objective. Algorithms are realized usually by means of implementation as computer programs for execution by automata." []
subset: https://www.fairsharing.org
is_a: IAO:0000104 ! plan specification
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl

[Term]
id: IAO:0000088
name: report
def: "A document assembled by an author for the purpose of providing information for the audience. A report is the output of a documenting process and has the objective to be consumed by a specific audience. Topic of the report is on something that has completed. A report is not a single figure. Examples of reports are journal article, patent application, grant progress report, case report (not patient record)." []
is_a: IAO:0000310 ! document
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl

[Term]
id: IAO:0000101
name: image
def: "An image is an affine projection to a two dimensional surface, of measurements of some quality of an entity or entities repeated at regular intervals across a spatial range, where the measurements are represented as color and luminosity on the projected on surface." []
is_a: IAO:0000308 ! figure
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl

[Term]
id: IAO:0000104
name: plan specification
def: "A directive information entity with action specifications and objective specifications as parts, and that may be concretized as a realizable entity that, if realized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified." []
is_a: IAO:0000033 ! directive information entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: IAO:0000183
name: dendrogram
def: "A dendrogram is a report graph which is a tree diagram\nfrequently used to illustrate the arrangement of the clusters produced by a\nclustering algorithm." []
subset: https://www.fairsharing.org
is_a: IAO:0000038 ! graph
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl

[Term]
id: IAO:0000308
name: figure
def: "An information content entity consisting of a two dimensional arrangement of information content entities such that the arrangement itself is about something." []
is_a: IAO:0000030 ! information content entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl

[Term]
id: IAO:0000309
name: diagram
def: "A figure that expresses one or more propositions" []
is_a: IAO:0000308 ! figure
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl

[Term]
id: IAO:0000310
name: document
def: "A collection of information content entities intended to be understood together as a whole" []
is_a: IAO:0000030 ! information content entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl

[Term]
id: IAO:0000313
name: patent
def: "A document that has been accepted by a patent authority" []
subset: https://www.fairsharing.org
is_a: IAO:0000310 ! document
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl

[Term]
id: IAO:0000314
name: document part
def: "An information content entity that is part of a document." []
is_a: IAO:0000030 ! information content entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl

[Term]
id: IAO:0000572
name: documenting
def: "A planned process in which a document is created or added to by including the specified input in it." []
subset: https://www.fairsharing.org
is_a: OBI:0000011 ! planned process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl

[Term]
id: IAO:0000578
name: centrally registered identifier
def: "An information content entity that consists of a CRID symbol and additional information about the CRID registry to which it belongs." []
subset: https://www.fairsharing.org
is_a: IAO:0020000 ! identifier
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl

[Term]
id: IAO:0020000
name: identifier
def: "An information content entity that is the outcome of a dubbing process and is used to refer to one instance of entity shared by a group of people to refer to that individual entity." []
is_a: IAO:0000030 ! information content entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl

[Term]
id: MF:0000020
name: mental process
def: "A bodily process that occurs in the brain, and that can of itself be conscious, or can give rise to a process that can of itself be conscious or can give rise to behaviour." []
is_a: GO:0008150 ! biological_process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mfoem.owl

[Term]
id: MFOEM:000001
name: emotion process
def: "An affective process that is a synchronized aggregate of constituent mental processes including an appraisal process, which is valenced, has an object, and gives rise to an action tendency." []
subset: https://www.fairsharing.org
is_a: MF:0000020 ! mental process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mfoem.owl

[Term]
id: MI:0000
name: molecular interaction
def: "Controlled vocabularies originally created for protein protein interactions, extended to other molecules interactions." []
subset: https://www.fairsharing.org
is_a: GO:0008150 ! biological_process
property_value: IAO:0000118 "mi" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mi.owl

[Term]
id: MI:0064
name: interologs mapping
def: "Protein interactions, experimentally detected in an organism, are extended to a second organism assuming that homologue proteins, in different organisms, maintain their interaction properties." []
subset: https://www.fairsharing.org
is_a: edam:operation_2492 ! Protein interaction prediction
property_value: IAO:0000118 "Homology based interaction prediction" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mi.owl

[Term]
id: MI:0074
name: mutation analysis
def: "Mutant molecules are produced by random or directed techniques and assayed for their ability to support binding." []
subset: https://www.fairsharing.org
is_a: OBI:0000070 ! assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mi.owl

[Term]
id: MI:0093
name: protein sequence identification
def: "Single amino acid identification along a protein sequence." []
subset: https://www.fairsharing.org
is_a: edam:operation_3767 ! Protein identification
property_value: IAO:0000118 "protein sequence" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mi.owl

[Term]
id: MI:0118
name: mutation
def: "A change in a sequence or structure in comparison to a reference entity due to a  insertion, deletion or substitution event." []
subset: https://www.fairsharing.org
is_a: SO:0001059 ! sequence_alteration
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mi.owl

[Term]
id: MI:0208
name: genetic interaction (sensu unexpected)
def: "An effect in which two genetic perturbations, when combined, result in a phenotype that does not appear to be merely explained by the superimposition or addition of effects of the original perturbations.\nab (not=) E" []
subset: https://www.fairsharing.org
is_a: MI:0000 ! molecular interaction
property_value: IAO:0000118 "Fisher epistasis" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mi.owl

[Term]
id: MI:0328
name: small molecule
def: "Molecule not part of or directly encoded by the genome, encompasses any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer, etc., identifiable as a separately distinguishable entity." []
subset: https://www.fairsharing.org
is_a: CHEBI:23367 ! molecular entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mi.owl

[Term]
id: MI:0414
name: enzymatic reaction
def: "terms aiming to represent biochemical reactions referring to their resulting product modifications." []
subset: https://www.fairsharing.org
is_a: MI:0914 ! association
property_value: IAO:0000118 "Biochemical reaction" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mi.owl

[Term]
id: MI:0914
name: association
def: "Interaction between molecules that may participate in formation of one, but possibly more, physical complexes. Often describes a set of molecules that are co-purified in a single pull-down or coimmunoprecipitation but might participate in formation of distinct physical complexes sharing a common bait." []
subset: https://www.fairsharing.org
is_a: MI:0000 ! molecular interaction
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mi.owl

[Term]
id: MI:0964
name: infrared spectroscopy
def: "Subset of spectroscopy that deals with the infrared region of the electromagnetic spectrum." []
subset: https://www.fairsharing.org
is_a: OBI:0000070 ! assay
property_value: IAO:0000118 "ir spectrometry" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mi.owl

[Term]
id: MI:0966
name: ultraviolet-visible spectroscopy
def: "Ultraviolet-visible spectroscopy or ultraviolet-visible spectrophotometry (UV-Vis or UV/Vis) involves the spectroscopy of photons in the UV-visible region. This means it uses light in the visible and adjacent (near ultraviolet (UV) and near infrared (NIR)) ranges." []
subset: https://www.fairsharing.org
is_a: OBI:0000070 ! assay
property_value: IAO:0000118 "ultraviolet-visible spectrophotometry" xsd:string
property_value: IAO:0000118 "uv-vis" xsd:string
property_value: IAO:0000118 "UV/Vis" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mi.owl

[Term]
id: MI:1100
name: bioactive entity
def: "Molecules showing activity in a living system but not encoded by a genomic sequence." []
subset: https://www.fairsharing.org
is_a: MI:0000 ! molecular interaction
property_value: IAO:0000118 "bioactive entity" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mi.owl

[Term]
id: MI:2025
name: molecular weight
def: "Molecular weight in g/mol, determined from molecular formula or sequence." []
subset: https://www.fairsharing.org
is_a: edam:data_2087 ! Molecular property
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mi.owl

[Term]
id: MI:2030
name: isoelectric point
def: "The isoelectric point (pI) is the pH at which a particular molecule or surface carries no net electrical charge. For an amino acid with only one amine and one carboxyl group, the pI can be calculated from the pKas of this molecule." []
subset: https://www.fairsharing.org
is_a: edam:data_2087 ! Molecular property
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mi.owl

[Term]
id: MI:2190
name: long non-coding ribonucleic acid
def: "Non-protein coding transcripts longer than 200 nucleotides and that can be involved in a number of functions, like transcription, post-translational and epigenetic regulation. Most lncRNAs do not have a known function so far." []
subset: https://www.fairsharing.org
is_a: CHEBI:33696 ! nucleic acid
property_value: IAO:0000118 "lncRNA" xsd:string
property_value: IAO:0000118 "lncrna" xsd:string
property_value: IAO:0000118 "long non coding ribonucleic acid" xsd:string
property_value: IAO:0000118 "long non coding RNA" xsd:string
property_value: IAO:0000118 "long non-coding RNA" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mi.owl

[Term]
id: MI:2231
name: coexpression
def: "This approach infers interacting pairs of proteins looking at expression data coming from transcript expression datasets. Co-expressed pairs of genes are ranked and predicted to be interacting proteins as well." []
subset: https://www.fairsharing.org
is_a: OBI:0200000 ! data transformation
property_value: IAO:0000118 "co-expression" xsd:string
property_value: IAO:0000118 "coexpression" xsd:string
property_value: IAO:0000118 "coexpression prediction" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mi.owl

[Term]
id: MOD:00693
name: glycosylated residue
def: "A protein modification that effectively replaces a hydrogen atom with an carbohydrate-like group through a glycosidic bond." []
subset: https://www.fairsharing.org
is_a: GO:0036211 ! protein modification process
property_value: IAO:0000118 "GlycoRes" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mod.owl

[Term]
id: MP:0000001
name: mammalian phenotype
def: "the observable morphological, physiological, behavioral and other characteristics of mammalian organisms that are manifested through development and lifespan" []
is_a: OGMS:0000023 ! phenotype
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mp.owl

[Term]
id: MP:0002555
name: addiction
def: "strong dependence on an addictive compound such as alcohol or narcotics that results in uncontrollable cravings for such compounds" []
subset: https://www.fairsharing.org
is_a: MP:0000001 ! mammalian phenotype
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mp.owl

[Term]
id: MP:0003935
name: abnormal craniofacial development
def: "anomaly in the process of forming the face and/or cranium" []
subset: https://www.fairsharing.org
is_a: MP:0005382 ! craniofacial phenotype
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mp.owl

[Term]
id: MP:0005382
name: craniofacial phenotype
def: "the observable morphological and physiological characteristics of the face or head of a mammalian organism that are manifested through development and lifespan" []
subset: https://www.fairsharing.org
is_a: MP:0000001 ! mammalian phenotype
property_value: IAO:0000412 http://purl.obolibrary.org/obo/mp.owl

[Term]
id: MS:1001193
name: confidence score
def: "Result of quality estimation: confidence score." []
subset: https://www.fairsharing.org
is_a: IAO:0000027 ! data item
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ms.owl

[Term]
id: NCBITaxon:408172
name: marine metagenome
subset: https://www.fairsharing.org
is_a: OMIT:0026082 ! Metagenome
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl

[Term]
id: NCIT:C101293
name: Next Generation Sequencing
def: "Technologies that facilitate the rapid determination of the nucleotide sequence of large numbers of strands or segments of DNA or RNA." []
subset: https://www.fairsharing.org
is_a: OBI:0600047 ! sequencing assay
property_value: IAO:0000118 "Massively Parallel DNA Sequencing" xsd:string
property_value: IAO:0000118 "Massively Parallel Sequencing" xsd:string
property_value: IAO:0000118 "NEXT GENERATION SEQUENCING" xsd:string
property_value: IAO:0000118 "Next Generation Sequencing" xsd:string
property_value: IAO:0000118 "Next Generational Sequencing" xsd:string
property_value: IAO:0000118 "Next-Generation Sequencing" xsd:string
property_value: IAO:0000118 "NGS" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C104154
name: Circulating Cell-Free RNA
def: "RNA found in blood plasma and other bodily fluids that is not associated with cells." []
subset: https://www.fairsharing.org
is_a: CHEBI:33697 ! ribonucleic acid
property_value: IAO:0000118 "cfRNA" xsd:string
property_value: IAO:0000118 "Circulating Cell-Free RNA" xsd:string
property_value: IAO:0000118 "Circulating RNA" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C114185
name: Polysomnography
def: "A group of tests taken during sleep to capture and record brain wave changes, eye movements, breathing rate, blood pressure, heart rate, and the electrical activity of the heart and other muscles." []
subset: https://www.fairsharing.org
is_a: OBI:0000070 ! assay
property_value: IAO:0000118 "POLYSOMNOGRAPHY" xsd:string
property_value: IAO:0000118 "Polysomnography" xsd:string
property_value: IAO:0000118 "PSG" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C13302
name: Secondary Protein Structure
def: "The specific 3-dimensional folded protein structure that is determined by the hydrogen bonds formed between amino acids in the polypeptide chain." []
subset: https://www.fairsharing.org
is_a: edam:data_1460 ! Protein structure
property_value: IAO:0000118 "Secondary Protein Structure" xsd:string
property_value: IAO:0000118 "Secondary Structure" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C13375
name: Chromosome Fragile Site
def: "Heritable sensitive regions of chromosomes which show up in vitro as non-staining bands. They are associated with chromosome breakage and other aberrations. No abnormal phenotype has been definitely identified with autosomal fragile sites, but some rare autosomal recessive disorders may be due to homozygosity for fragile sites. A fragile site on the X chromosome is associated with Fragile X Syndrome. Fragile sites are designated by the letters \"fra\" followed by the designation for the specific chromosome and locus." []
subset: https://www.fairsharing.org
is_a: GO:0098687 ! chromosomal region
property_value: IAO:0000118 "Chromosome Fragile Site" xsd:string
property_value: IAO:0000118 "FRAGILE SITE" xsd:string
property_value: IAO:0000118 "Fragile Site" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C13426
name: Protein Binding Domain
def: "Protein Binding Domains are structural motifs responsible for the peptide/protein binding activity of proteins." []
subset: https://www.fairsharing.org
is_a: SO:0000409 ! binding_site
property_value: IAO:0000118 "Protein Binding Domain" xsd:string
property_value: IAO:0000118 "Protein Binding Motif" xsd:string
property_value: IAO:0000118 "Protein-Protein Interaction Domain" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C13445
name: Gene Feature
def: "The structural elements that comprise a gene or transcription unit. Gene structures include the transcription initiation site, the protein coding sequences, intervening sequences, and the transcription termination or polyadenylation sites as well as the regulatory elements (enhancers, silencers, and the promoter) that lie outside the boundaries of the transcribed unit." []
subset: https://www.fairsharing.org
is_a: SO:0001411 ! biological_region
property_value: IAO:0000118 "Gene Feature" xsd:string
property_value: IAO:0000118 "Gene Organization" xsd:string
property_value: IAO:0000118 "Gene Structure" xsd:string
property_value: IAO:0000118 "Gene Structure/Organization" xsd:string
property_value: IAO:0000118 "Seq Feature" xsd:string
property_value: IAO:0000118 "Sequence Feature" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C142529
name: Electronic Health Record
def: "A digital version of a patient's medical history." []
subset: https://www.fairsharing.org
is_a: OGMS:0000123 ! clinical data item
property_value: IAO:0000118 "EHR" xsd:string
property_value: IAO:0000118 "EHR (electronic health record)" xsd:string
property_value: IAO:0000118 "Electronic Health Record" xsd:string
property_value: IAO:0000118 "From Electronic Health Record" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C15239
name: Patient Care
def: "Any of the services rendered for the benefit of a patient." []
subset: https://www.fairsharing.org
is_a: OAE:0000094 ! therapeutic intervention
property_value: IAO:0000118 "Patient Care" xsd:string
property_value: IAO:0000118 "Patient Care Delivery" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C15311
name: Quality Control
def: "Set of measurements and inspections taken to verify that performance of equipment and procedures remains within specified limits." []
subset: https://www.fairsharing.org
is_a: OBI:0000011 ! planned process
property_value: IAO:0000118 "QA Report" xsd:string
property_value: IAO:0000118 "QC" xsd:string
property_value: IAO:0000118 "Quality Control" xsd:string
property_value: IAO:0000118 "quality control (QC)" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C15318
name: Reproducibility
def: "The ability to yield similar results given a set of constraints." []
subset: https://www.fairsharing.org
is_a: PATO:0000068 ! qualitative
property_value: IAO:0000118 "Reproducibility" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C15959
name: Cellular Assay
def: "In vitro experiments conducted with intact, living cells." []
subset: https://www.fairsharing.org
is_a: OBI:0000070 ! assay
property_value: IAO:0000118 "Cellular Assay" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C16507
name: DNA Damage
def: "Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis." []
subset: https://www.fairsharing.org
is_a: OBI:1110122 ! pathologic process
property_value: IAO:0000118 "DNA Damage" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C16565
name: Evolution
def: "The process by which organism populations change over successive generations that is influenced by gene mutation and natural selection." []
subset: https://www.fairsharing.org
is_a: UBERON:0000000 ! processual entity
property_value: IAO:0000118 "Evolution" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C16622
name: Genetic Marker
def: "A segment of DNA with an identifiable physical location on a chromosome and whose inheritance can be followed." []
subset: https://www.fairsharing.org
is_a: CHEBI:59163 ! biomarker
property_value: IAO:0000118 "Genetic Marker" xsd:string
property_value: IAO:0000118 "genetic marker" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C16710
name: Immunity
def: "The protection against infectious disease conferred by the immune response. It encompasses the capacity to distinguish foreign material from self, and to neutralize, eliminate, or metabolize that which is foreign." []
subset: https://www.fairsharing.org
is_a: GO:0032501 ! multicellular organismal process
property_value: IAO:0000118 "Immunity" xsd:string
property_value: IAO:0000118 "immunity" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C16809
name: Magnetic Resonance Imaging
def: "Imaging that uses radiofrequency waves and a strong magnetic field rather than x-rays to provide detailed pictures of internal organs and tissues. The technique is valuable for the diagnosis of many pathologic conditions, including cancer, heart and vascular disease, stroke, and joint and musculoskeletal disorders." []
subset: https://www.fairsharing.org
is_a: edam:topic_3382 ! Imaging
property_value: IAO:0000118 "Magnetic Resonance" xsd:string
property_value: IAO:0000118 "Magnetic Resonance Imaging" xsd:string
property_value: IAO:0000118 "magnetic resonance imaging" xsd:string
property_value: IAO:0000118 "Magnetic Resonance Imaging (MRI)" xsd:string
property_value: IAO:0000118 "Magnetic resonance imaging (procedure)" xsd:string
property_value: IAO:0000118 "Magnetic Resonance Imaging Scan" xsd:string
property_value: IAO:0000118 "Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance" xsd:string
property_value: IAO:0000118 "MR" xsd:string
property_value: IAO:0000118 "MR Imaging" xsd:string
property_value: IAO:0000118 "MRI" xsd:string
property_value: IAO:0000118 "MRI Scan" xsd:string
property_value: IAO:0000118 "MRIs" xsd:string
property_value: IAO:0000118 "NMR Imaging" xsd:string
property_value: IAO:0000118 "NMRI" xsd:string
property_value: IAO:0000118 "Nuclear Magnetic Resonance Imaging" xsd:string
property_value: IAO:0000118 "nuclear magnetic resonance imaging" xsd:string
property_value: IAO:0000118 "sMRI" xsd:string
property_value: IAO:0000118 "Structural MRI" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C17004
name: Genetic Polymorphism
def: "The regular and simultaneous occurrence of alternative nucleotide sequences at equivalent locations of the genetic material among individuals of a single interbreeding population that are not maintained by recurrent mutation. Polymorphisms may range in size from single nucleotide to large nucleotide sequence variation visible at the chromosomal level." []
subset: https://www.fairsharing.org
is_a: SO:0001059 ! sequence_alteration
property_value: IAO:0000118 "Genetic Polymorphism" xsd:string
property_value: IAO:0000118 "Polymorphism" xsd:string
property_value: IAO:0000118 "polymorphism" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C17007
name: Positron Emission Tomography
def: "A technique for measuring the gamma radiation produced by collisions of electrons and positrons (anti-electrons) within living tissue. In positron emission tomography (PET), a subject is given a dose of a positron-emitting radionuclide attached to a metabolically active substance (for example, 2-fluoro-2-deoxy-D-glucose (FDG), which is similar to a naturally occurring sugar, glucose, with the addition of a radioactive fluorine atom). When living tissue containing the positron emitter is bombarded by electrons, gamma radiation produced by collisions of electrons and positrons is detected by a scanner, revealing in fine detail the tissue location of the metabolically-active substance administered." []
subset: https://www.fairsharing.org
is_a: edam:topic_3382 ! Imaging
property_value: IAO:0000118 "Medical Imaging, Positron Emission Tomography" xsd:string
property_value: IAO:0000118 "PET" xsd:string
property_value: IAO:0000118 "PET SCAN" xsd:string
property_value: IAO:0000118 "PET Scan" xsd:string
property_value: IAO:0000118 "PET scan" xsd:string
property_value: IAO:0000118 "Pet Scan" xsd:string
property_value: IAO:0000118 "Positron Emission Tomography" xsd:string
property_value: IAO:0000118 "Positron emission tomography (procedure)" xsd:string
property_value: IAO:0000118 "Positron Emission Tomography Scan" xsd:string
property_value: IAO:0000118 "positron emission tomography scan" xsd:string
property_value: IAO:0000118 "Positron-Emission Tomography" xsd:string
property_value: IAO:0000118 "proton magnetic resonance spectroscopic imaging" xsd:string
property_value: IAO:0000118 "PT" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C17207
name: Transcription Factor
def: "Transcription factors are a diverse group of proteins that bind to DNA at specific promoter or enhancer regions. They also bind to DNA-associated proteins to initiate, stimulate, inhibit or terminate transcription. The proteins are often physically associated in a preinitiation complex and contain structural motifs." []
subset: https://www.fairsharing.org
is_a: PR:000000001 ! protein
property_value: IAO:0000118 "Transcription Factor" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C17253
name: Viral Genome
def: "The total complement of hereditary material in a virus, which can be composed of either DNA or RNA." []
subset: https://www.fairsharing.org
is_a: SO:0001026 ! genome
property_value: IAO:0000118 "Viral Genome" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C17671
name: Nuclear Receptor
def: "Proteins that regulate transcription via interaction with chromatin and basal transcription machinery at the promoter regions of genes. Nuclear receptors are ligand-dependent transcription factors including steroids, retinoids, vitamin D, unliganded thyroid hormone, and orphan receptors (unknown ligands). Coregulators (coactivators or corepressors) are important in mediating these interactions and thereby modulate positive or negative receptor activity." []
subset: https://www.fairsharing.org
is_a: NCIT:C17207 ! Transcription Factor
is_a: NCIT:C18106 ! Receptor
property_value: IAO:0000118 "Nuclear Receptor" xsd:string
property_value: IAO:0000118 "Receptor, Nuclear" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C17958
name: Functional Magnetic Resonance Imaging
def: "The principle of functional MRI imaging is to take a series of images of an organ in quick succession and to statistically analyze the images for differences among them.  Most commonly used in studies of brain function." []
subset: https://www.fairsharing.org
is_a: NCIT:C16809 ! Magnetic Resonance Imaging
property_value: IAO:0000118 "fMRI" xsd:string
property_value: IAO:0000118 "Functional Magnetic Resonance Imaging" xsd:string
property_value: IAO:0000118 "functional magnetic resonance imaging" xsd:string
property_value: IAO:0000118 "FUNCTIONAL MRI" xsd:string
property_value: IAO:0000118 "Functional MRI" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C18106
name: Receptor
def: "A protein located on the cell surface, or in the cytoplasm, that binds to a specific signaling factor, such as a hormone, antigen, or neurotransmitter, causing a conformational and functional change in the receptor molecule.  The ligand-bound receptor then alters its interaction with target molecules, which leads to changes in cellular physiology through modification of the activity of one or more signal transduction pathways." []
subset: https://www.fairsharing.org
is_a: GO:0005622 ! intracellular anatomical structure
property_value: IAO:0000118 "Receptor" xsd:string
property_value: IAO:0000118 "receptor" xsd:string
property_value: IAO:0000118 "Receptor Protein" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C18143
name: Gene Knockout
def: "Refers to the targeted disruption of a gene within its normal biological context.  Utilized to examine the involvement of a gene in a complex biological process." []
subset: https://www.fairsharing.org
is_a: OBI:0000094 ! material processing
property_value: IAO:0000118 "Gene Knockout" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C18469
name: Protein-Protein Interaction
def: "Temporary, non-covalent binding between protein molecules. Protein-protein interactions occur as a result of intermolecular physical forces and spatial complementation between domains or motifs. This interaction can be either homotypic or heterotypic and effect protein structure, conformation, and function." []
subset: https://www.fairsharing.org
is_a: edam:topic_0128 ! Protein interactions
property_value: IAO:0000118 "Protein-Protein Interaction" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C18472
name: High Throughput Screening
def: "Use of robots and other automated techniques to screen large numbers of samples." []
subset: https://www.fairsharing.org
is_a: OBI:0000070 ! assay
property_value: IAO:0000118 "High Throughput Assay" xsd:string
property_value: IAO:0000118 "High Throughput Screening" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C18962
name: Protein Analysis
def: "Analysis of protein components in a sample.  The most basic analysis involves determination of the mass or concentration of protein by any of a number of quantitative assays.  Increased level of detail in the analysis requires resolution of a mixture into its component proteins.  The characterization of a pure protein includes the determination of a number of its properties, among these, the molecular weight, isoelectric point, subunit composition, tryptic map, amino acid composition, amino acid sequence, hydrodynamics (s value, frictional coefficient, shape, aggregation state), thermodynamics (melting, folding, protein-protein interactions), and atomic structure (NMR, diffraction)." []
subset: https://www.fairsharing.org
is_a: edam:operation_2945 ! Data analysis
property_value: IAO:0000118 "Protein Analysis" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C18966
name: Protein Expression
def: "The biosynthesis of new (often sets of distinct, functionally related) protein products, usually involving new mRNA transcripts, typically in response to an activating stimulus." []
subset: https://www.fairsharing.org
is_a: GO:0043043 ! peptide biosynthetic process
property_value: IAO:0000118 "Expressed" xsd:string
property_value: IAO:0000118 "Protein Expression" xsd:string
property_value: IAO:0000118 "protein expression" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C26549
name: Untranslated RNA
def: "The product of so-called RNA genes; a functional RNA represents the final product of a gene rather than a transient molecule that will be translated into protein." []
subset: https://www.fairsharing.org
is_a: CHEBI:33697 ! ribonucleic acid
property_value: IAO:0000118 "Functional RNA" xsd:string
property_value: IAO:0000118 "ncRNA" xsd:string
property_value: IAO:0000118 "Non-Coding RNA" xsd:string
property_value: IAO:0000118 "Noncoding RNA" xsd:string
property_value: IAO:0000118 "Untranslated RNA" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C41332
name: Adverse Reaction
def: "Any noxious and unintended response(s) to a medical product or procedure, for which a causal relationship with this product or procedure is at least a reasonable possibility i.e., the relationship cannot be ruled out." []
subset: https://www.fairsharing.org
is_a: GO:0008150 ! biological_process
property_value: IAO:0000118 "ADR" xsd:string
property_value: IAO:0000118 "Adverse Effect" xsd:string
property_value: IAO:0000118 "adverse effect" xsd:string
property_value: IAO:0000118 "ADVERSE REACTION" xsd:string
property_value: IAO:0000118 "Adverse Reaction" xsd:string
property_value: IAO:0000118 "adverse reaction" xsd:string
property_value: IAO:0000118 "AR" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C45275
name: Tracking
def: "The act or process of following a person, animal, or object through space or time." []
subset: https://www.fairsharing.org
is_a: OBI:0000011 ! planned process
property_value: IAO:0000118 "Tracking" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C453
name: Recombinant DNA
def: "Biologically active DNA which has been formed by the in vitro joining of segments of DNA from different sources usually for the purpose of genetic manipulation." []
subset: https://www.fairsharing.org
is_a: CHEBI:16991 ! deoxyribonucleic acid
property_value: IAO:0000118 "Construct" xsd:string
property_value: IAO:0000118 "DNA Construct" xsd:string
property_value: IAO:0000118 "Molecular Biology, Recombinant DNA" xsd:string
property_value: IAO:0000118 "Recombinant DNA" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C4873
name: Rare Disorder
def: "A non-neoplastic or neoplastic disorder that is uncommon." []
subset: https://www.fairsharing.org
is_a: OGMS:0000031 ! disease
property_value: IAO:0000118 "Rare Disease" xsd:string
property_value: IAO:0000118 "Rare Diseases" xsd:string
property_value: IAO:0000118 "Rare Disorder" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C49667
name: Safety Study
def: "A study of the relative safety of treatment of a disease. Usually this is a Phase I or II trial." []
subset: https://www.fairsharing.org
is_a: OBI:0000066 ! investigation
property_value: IAO:0000118 "SAFETY" xsd:string
property_value: IAO:0000118 "Safety Study" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C61256
name: Monitoring
def: "The act of observing something (and sometimes keeping a record of it)." []
subset: https://www.fairsharing.org
is_a: OBI:0000070 ! assay
property_value: IAO:0000118 "monitor" xsd:string
property_value: IAO:0000118 "Monitoring" xsd:string
property_value: IAO:0000118 "monitoring" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C64862
name: Diffusion Tensor Imaging
def: "A type of diffusion-weighted magnetic resonance imaging (DW-MRI) that maps the diffusion of water in three dimensions, the principal purpose of which is to image the white matter of the brain, specifically measuring the anisotropy, location, and orientation of the neural tracts, which can demonstrate microstructural changes or differences with neuropathology and treatment." []
subset: https://www.fairsharing.org
is_a: NCIT:C16809 ! Magnetic Resonance Imaging
property_value: IAO:0000118 "Diffusion Tensor Imaging" xsd:string
property_value: IAO:0000118 "DIFFUSION TENSOR MRI" xsd:string
property_value: IAO:0000118 "DT-MRI" xsd:string
property_value: IAO:0000118 "DTI" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C66892
name: Natural Product
def: "Any whole or part of a plant (including plant exudates), animal or microorganism that is unprocessed (raw material), or that has been processed, pulverized or extracted. Many of the natural products have some biological and/or pharmacological activity or are used for a specific purpose, not necessarily medicinal (food, aroma therapy, research and etc.). This class does not include any individual substance derived from plants/animals or other organisms with specific pharmacologic activity (See Drug, Natural Product)." []
subset: https://www.fairsharing.org
is_a: BFO:0000040 ! material entity
property_value: IAO:0000118 "Natural Product" xsd:string
property_value: IAO:0000118 "Natural Products" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C68821
name: Regulation
def: "A rule or order issued by an authority stating what may or may not be done or how something must be done." []
subset: https://www.fairsharing.org
is_a: IAO:0000310 ! document
property_value: IAO:0000118 "Regulated" xsd:string
property_value: IAO:0000118 "Regulation" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: NCIT:C70699
name: Biospecimen
def: "Any material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes, including a sample obtained from a living organism or taken from the biological object after halting of all its life functions. Biospecimen can contain one or more components including but not limited to cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory products." []
subset: https://www.fairsharing.org
is_a: OBI:0100051 ! specimen
property_value: IAO:0000118 "Bio-Specimen" xsd:string
property_value: IAO:0000118 "Biological Sample" xsd:string
property_value: IAO:0000118 "Biological Specimen" xsd:string
property_value: IAO:0000118 "BiologicSpecimen" xsd:string
property_value: IAO:0000118 "BIOSPECIMEN" xsd:string
property_value: IAO:0000118 "Biospecimen" xsd:string
property_value: IAO:0000118 "biospecimen" xsd:string
property_value: IAO:0000118 "Sample" xsd:string
property_value: IAO:0000118 "sample" xsd:string
property_value: IAO:0000118 "Specimen" xsd:string
property_value: IAO:0000118 "specimen" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl

[Term]
id: OAE:0000002
name: medical intervention
def: "medical intervention is a planned process that has the goal of diagnosing, preventing or relieving illness or injury." []
is_a: OBI:0000011 ! planned process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/oae.owl

[Term]
id: OAE:0000094
name: therapeutic intervention
def: "a medical intervention that is used for therapeutic purpose" []
is_a: OAE:0000002 ! medical intervention
property_value: IAO:0000412 http://purl.obolibrary.org/obo/oae.owl

[Term]
id: OAE:0000235
name: radiotherapy
def: "a therapeutic intervention that uses radiation" []
subset: https://www.fairsharing.org
is_a: OAE:0000094 ! therapeutic intervention
property_value: IAO:0000412 http://purl.obolibrary.org/obo/oae.owl

[Term]
id: OBCS:0000049
name: accuracy
def: "A data item that refers to the number of true positives and true negatives divided by the total number of observations." []
subset: https://www.fairsharing.org
is_a: OBCS:0000220 ! derived data from inferential statistical analysis
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obcs.owl

[Term]
id: OBCS:0000218
name: derived data from statistical analysis
def: "A data item that is derived from a statistical data analysis." []
is_a: OBCS:0000233 ! transformed data item
property_value: IAO:0000118 "statistic" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obcs.owl

[Term]
id: OBCS:0000220
name: derived data from inferential statistical analysis
def: "A data item that is derived from an inferential statistical data analysis." []
is_a: OBCS:0000218 ! derived data from statistical analysis
property_value: IAO:0000118 "inferential statistic" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obcs.owl

[Term]
id: OBCS:0000233
name: transformed data item
def: "A data item that is produced as the output of a data transformation." []
is_a: IAO:0000027 ! data item
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obcs.owl

[Term]
id: OBI:0000011
name: planned process
def: "A process that realizes a plan which is the concretization of a plan specification." []
is_a: BFO:0000015 ! process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/oae.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/stato.owl

[Term]
id: OBI:0000047
name: processed material
def: "Is a material entity that is created or changed during material processing." []
is_a: BFO:0000040 ! material entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/vo.owl

[Term]
id: OBI:0000066
name: investigation
def: "a planned process that consists of parts: planning, study design execution, documentation and which produce conclusion(s)." []
is_a: OBI:0000011 ! planned process
property_value: IAO:0000118 "study" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/stato.owl

[Term]
id: OBI:0000070
name: assay
def: "A planned process with the objective to produce information about the material entity that is the evaluant, by physically examining it or its proxies." []
subset: https://www.fairsharing.org
is_a: OBI:0000011 ! planned process
property_value: IAO:0000118 "measurement method" xsd:string
property_value: IAO:0000118 "measuring" xsd:string
property_value: IAO:0000118 "scientific observation" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000073
name: sample preparation for assay
def: "A sample_preparation_for_assay is a protocol_application including material_enrollments and biomaterial_transformations. definition_source: OBI." []
subset: https://www.fairsharing.org
is_a: OBI:0000094 ! material processing
property_value: IAO:0000118 "study" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000094
name: material processing
def: "A planned process which results in physical changes in a specified input material." []
subset: https://www.fairsharing.org
is_a: OBI:0000011 ! planned process
property_value: IAO:0000118 "material transformation" xsd:string
property_value: IAO:0000118 "material transformations" xsd:string
property_value: IAO:0000118 "preparative method" xsd:string
property_value: IAO:0000118 "sample preparation" xsd:string
property_value: IAO:0000118 "sample preparation step" xsd:string
property_value: IAO:0000118 "sample preparative method" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000115
name: intervention design
def: "An intervention design is a study design in which a controlled process applied to the subjects (the intervention) serves as the independent variable manipulated by the experimentalist. The treatment (perturbation or intervention) defined can be defined as a combination of values taken by independent variable manipulated by the experimentalists are applied to the recruited subjects assigned (possibly by applying specific methods) to treatment groups. The specificity of intervention design is the fact that independent variables are being manipulated and a response of the biological system is evaluated via response variables as monitored by possibly a series of assays." []
subset: https://www.fairsharing.org
is_a: OBI:0500000 ! study design
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000181
name: population
def: "A population is a group of material entities consisting of individuals which share a particular characteristic such as inhabiting a particular region or area or ability to interbreed." []
is_a: BFO:0000040 ! material entity
property_value: IAO:0000412 efo:efo.owl

[Term]
id: OBI:0000185
name: imaging assay
def: "An imaging assay is an assay to produce a picture of an entity." []
is_a: OBI:0000070 ! assay
property_value: IAO:0000118 "imaging assay" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/chmo.owl

[Term]
id: OBI:0000231
name: enzymatic cleavage
def: "a material processing that digests the fraction of input material that is susceptible to that enzyme" []
is_a: OBI:0000094 ! material processing
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000245
name: organization
def: "An entity that can bear roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members." []
is_a: BFO:0000040 ! material entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omrse.owl

[Term]
id: OBI:0000398
name: image creation device
def: "An image creation device is a device which captures a digitized image of an object" []
is_a: OBI:0000832 ! measurement device
property_value: IAO:0000118 "image acquisition device" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000415
name: polymerase chain reaction
def: "PCR is the process in which a DNA polymerase is used to amplify a piece of DNA by in vitro enzymatic replication. As PCR progresses, the DNA thus generated is itself used as a template for replication. This sets in motion a chain reaction in which the DNA template is exponentially amplified." []
subset: https://www.fairsharing.org
is_a: OBI:0600058 ! enzymatic amplification
property_value: IAO:0000118 "PCR" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000423
name: extract
def: "an extract is a material entity which results from an extraction process" []
subset: https://www.fairsharing.org
is_a: OBI:0000047 ! processed material
property_value: IAO:0000118 "extracted material" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000424
name: transcription profiling assay
def: "An assay that determines gene expression and transcription activity using ribonucleic acids collected from a material entity." []
is_a: OBI:0000070 ! assay
property_value: IAO:0000118 "gene expression profiling" xsd:string
property_value: IAO:0000118 "transcription profiling" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000427
name: enzyme
def: "(protein or rna) or has_part (protein or rna) and\nhas_function some GO:0003824 (catalytic activity)" []
subset: https://www.fairsharing.org
is_a: BFO:0000040 ! material entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000430
name: plasmid
def: "plasmid = DNA and has_quality circular and has_function\n(is_realized_as some gene expression) GO:0010467" []
subset: https://www.fairsharing.org
is_a: CHEBI:4705 ! double-stranded DNA
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000443
name: analyte assay
def: "An assay with the objective to capture information about the presence, concentration, or amount of an analyte in an evaluant." []
is_a: OBI:0000070 ! assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000454
name: extracellular electrophysiology recording assay
def: "An electrophysiology assay where the recording location of the electrode is extracellular." []
is_a: OBI:0002176 ! electrophysiology assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000470
name: mass spectrometry assay
def: "An assay that identifies the amount and type of material entities present in a sample by fragmenting the sample and measuring the mass-to-charge ratio of the resulting particles." []
subset: https://www.fairsharing.org
is_a: OBI:0000070 ! assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000615
name: protein expression profiling assay
def: "An assay that determines protein expression and translation activity using protein extracts collected from a material entity." []
subset: https://www.fairsharing.org
is_a: OBI:0000070 ! assay
property_value: IAO:0000118 "proteomic analysis" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000626
name: DNA sequencing assay
def: "A sequencing assay which determines information on the sequence of a DNA molecule." []
subset: https://www.fairsharing.org
is_a: OBI:0600047 ! sequencing assay
property_value: IAO:0000118 "nucleotide sequencing" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000680
name: whole organism preparation
def: "A material entity which is the output of a process in which one or more whole organisms are prepared in a way to make it easier to study them, and in which the great majority of organismal parts are maintained" []
is_a: NCIT:C70699 ! Biospecimen
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000716
name: ChIP-seq assay
def: "An assay in which chromatin is immunoprecipitated and subsequently analyzed using a DNA sequencing step to identify which parts of DNA are part of the isolated chromatin" []
subset: https://www.fairsharing.org
is_a: OBI:0001954 ! ChIP assay
property_value: IAO:0000118 "chromatin immunoprecipitation sequencing assay" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000725
name: host role
def: "host role is a role played by an organism and realized by providing nourishment, shelter or a means of reproduction to another organism within the organism playing the host role" []
subset: https://www.fairsharing.org
is_a: BFO:0000023 ! role
property_value: drao:DRAO_0000001 "host" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000726
name: peak matching
def: "Peak matching is a data transformation performed on a dataset of a graph of ordered data points (e.g. a spectrum) with the objective of pattern matching local maxima above a noise threshold" []
subset: https://www.fairsharing.org
is_a: OBI:0200000 ! data transformation
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000729
name: cloning plasmid
def: "A cloning plasmid is a plasmid that was engineered to contain a bacterial origin of replication, encodes for a selectable gene product and contains a cloning site." []
subset: https://www.fairsharing.org
is_a: OBI:0000430 ! plasmid
is_a: OBI:0000737 ! cloning vector
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000737
name: cloning vector
def: "A cloning vector is an engineered material that is used as an input material for a recombinant vector cloning process to carry inserted nucleic acids. It contains an origin of replication for a specific destination host organism, encodes for a selectable gene product and contains a cloning site." []
is_a: CHEBI:33696 ! nucleic acid
is_a: OBI:0000047 ! processed material
is_a: OBI:1110108 ! material to be added
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000750
name: study design independent variable
def: "a directive information entity that is part of a study design. Independent variables are entities whose values are selected to determine its relationship to an observed phenomenon (the dependent variable). In such an experiment, an attempt is made to find evidence that the values of the independent variable determine the values of the dependent variable (that which is being measured). The independent variable can be changed as required, and its values do not represent a problem requiring explanation in an analysis, but are taken simply as given. The dependent variable on the other hand, usually cannot be directly controlled" []
subset: https://www.fairsharing.org
is_a: IAO:0000033 ! directive information entity
property_value: IAO:0000118 "experimental factor" xsd:string
property_value: IAO:0000118 "independent variable" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000800
name: cross linking
def: "A process in which bonds are created that link one polymer to another" []
subset: https://www.fairsharing.org
is_a: OBI:0000094 ! material processing
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000832
name: measurement device
def: "A device in which a measure function inheres." []
is_a: OBI:0000968 ! device
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000893
name: real time polymerase chain reaction assay
def: "An assay, based on the PCR, that amplifies and simultaneously quantifies a specific DNA molecule based on the use of complementary probes/primers. It enables both detection and quantification (as absolute number of copies or relative amount when normalized to DNA input or additional normalizing genes) of one or more specific sequences in a DNA sample." []
subset: https://www.fairsharing.org
is_a: OBI:0002692 ! polymerase chain reaction assay
property_value: IAO:0000118 "kinetic polymerase chain reaction" xsd:string
property_value: IAO:0000118 "Q-PCR" xsd:string
property_value: IAO:0000118 "qPCR" xsd:string
property_value: IAO:0000118 "quantitative real time polymerase chain reaction" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000912
name: X-ray crystallography 3D molecular structure determination assay
def: "A 3D molecular structure determination assay in which the diffraction of pattern of X-ray beams in a crystal of purified material entities is used to resolve the 3-dimensional structure of the material entity of interest." []
subset: https://www.fairsharing.org
is_a: OBI:0003117 ! 3D molecular structure determination assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000916
name: flow cytometry assay
def: "A cytometry assay in which an input cell population is put in solution, is passed by a laser, and optical sensors are used to detect scattering of the laser light and/or fluorescence of specific markers to count and characterize the particles in solution." []
subset: https://www.fairsharing.org
is_a: OBI:0001977 ! cytometry assay
property_value: IAO:0000118 "FACS" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000940
name: optical microscope
def: "A microscope that produces an image of an object by targeting it with an electro-magnetic beam in the visible frequency range" []
is_a: OBI:0400169 ! microscope
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000953
name: processed specimen
def: "A specimen that has been intentionally physically modified." []
is_a: OBI:0000047 ! processed material
is_a: OBI:0100051 ! specimen
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000968
name: device
def: "A material entity that is designed to perform a function in a scientific investigation, but is not a reagent." []
subset: https://www.fairsharing.org
is_a: OBI:0000047 ! processed material
property_value: IAO:0000118 "instrument" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001065
name: stereo microscope
def: "An optical microscope that uses two separate optical paths with two objectives and two eyepieces to provide slightly different viewing angles to the left and right eyes." []
subset: https://www.fairsharing.org
is_a: OBI:0000940 ! optical microscope
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001173
name: service
def: "A planned process in which a service provider performs a task (i.e. a planned process) for a service consumer." []
is_a: OBI:0000011 ! planned process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001177
name: RNA sequencing assay
def: "An assay that determines the sequence of an RNA molecule." []
is_a: OBI:0600047 ! sequencing assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001199
name: in vivo design
def: "A study design that is conducted entirely in a living organism, e.g. a compound treatment in a mouse model." []
subset: https://www.fairsharing.org
is_a: OBI:0500000 ! study design
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001248
name: ChIP-chip assay
def: "An assay in which chromatin is immunoprecipitated and subsequently analyzed using a DNA microarray to identify which parts of DNA are part of the isolated chromatin" []
subset: https://www.fairsharing.org
is_a: OBI:0001954 ! ChIP assay
property_value: IAO:0000118 "ChIP-on-chip assay" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001271
name: RNA-seq assay
def: "An RNA sequencing assay that determines an RNA sequence by analyzing the transcibed regions of the genome and or to quantitate transcript abundance." []
subset: https://www.fairsharing.org
is_a: OBI:0001177 ! RNA sequencing assay
property_value: IAO:0000118 "transcription profiling by high throughput sequencing" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001515
name: material maintenance service
def: "A material processing service in which a service provider makes physical modifications to a specified input material, such that at least one of the specified outputs of this process is a modified version of a specified input material." []
is_a: OBI:0001528 ! material service
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001528
name: material service
def: "A service which has a material entity as specified input and/or specified output." []
is_a: OBI:0001173 ! service
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001557
name: material storage service
def: "A storage service in which a service consumer provides some material as input which a service provider stores and returns as output." []
subset: https://www.fairsharing.org
is_a: OBI:0001515 ! material maintenance service
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001632
name: immuno staining assay
def: "A assay detecting a molecular label assay in which the label is attached to an antibody so that substances are marked based on the antibody's binding specificity." []
is_a: OBI:0600017 ! assay detecting a molecular label
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001686
name: in-situ hybridization assay
def: "An assay that localizes a specific DNA or RNA sequence within a portion or section of tissue using artificially induced nucleic hybridization." []
subset: https://www.fairsharing.org
is_a: OBI:0000070 ! assay
property_value: IAO:0000118 "in situ hybridization" xsd:string
property_value: IAO:0000118 "ISH" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001848
name: chromatin interaction analysis by paired-end tag sequencing assay
def: "An assay that incorporates chromatin immunoprecipitation (ChIP)-based enrichment, chromatin proximity ligation, Paired-End Tags, and high-throughput sequencing to determine de novo long-range chromatin interactions genome-wide." []
subset: https://www.fairsharing.org
is_a: OBI:0002438 ! nuclear ligation assay
is_a: OBI:0600047 ! sequencing assay
property_value: IAO:0000118 "ChIA-PET" xsd:string
property_value: IAO:0000118 "ChIA-PET assay" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001850
name: transcript analysis by paired-end tag sequencing assay
def: "A transcription profiling assay that determines transcripts, gene structures, and gene expressions using Paired-End Tags and sequencing technology." []
subset: https://www.fairsharing.org
is_a: OBI:0000424 ! transcription profiling assay
is_a: OBI:0600047 ! sequencing assay
property_value: IAO:0000118 "RNA-PET" xsd:string
property_value: IAO:0000118 "RNA-PET assay" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001865
name: assay array
def: "A device made to be used in an analyte assay for immobilization of substances that bind the analyte at regular spatial positions on a surface." []
is_a: OBI:0000968 ! device
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001866
name: secondary cultured cell
is_a: CL:0000010 ! cultured cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl

[Term]
id: OBI:0001876
name: cell culture
def: "A material entity comprised of cultured cells and the media in which they are being propagated or stored." []
subset: https://www.fairsharing.org
is_a: OBI:0000047 ! processed material
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001905
name: secondary cultured cell population
is_a: OBI:0100060 ! cultured cell population
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl

[Term]
id: OBI:0001954
name: ChIP assay
def: "An assay in which portions of chromatin, the ordered and organized complex of DNA and its interaction partners that make up a chormosome, is extracted and purified by immunoprecipitation with antibodies or tags, and subsequently analyzed" []
is_a: OBI:0000070 ! assay
property_value: IAO:0000118 "chromatin immunoprecipitation assay" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001958
name: systematic review study design
def: "A study design for identifying in the literature prior studies of a pre-determined phenomenon or set of related phenomena according to certain criteria, extracting findings from these studies, and summarizing these findings and/or attempting to draw new conclusions from them which were not justified by any of the individual, prior studies. Many systematic reviews also assess the quality of the studies so reviewed." []
subset: https://www.fairsharing.org
is_a: OBI:0500000 ! study design
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001977
name: cytometry assay
def: "An assay that counts and/or measures characteristics of cells." []
is_a: OBI:0000070 ! assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001985
name: microarray assay
def: "An analyte assay where binding of the analyte to immobilized matrix is measured." []
subset: https://www.fairsharing.org
is_a: OBI:0000443 ! analyte assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0001986
name: immunohistochemistry
def: "An immunostaining assay to detect and potentially localize antigens within the cells of a tissue section." []
subset: https://www.fairsharing.org
is_a: OBI:0001632 ! immuno staining assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0002117
name: whole genome sequencing assay
def: "A DNA sequencing assay that intends to provide information about the sequence of an entire genome of an organism." []
subset: https://www.fairsharing.org
is_a: OBI:0000626 ! DNA sequencing assay
property_value: IAO:0000118 "WGS" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0002176
name: electrophysiology assay
def: "An assay that measures the electrical properties of biological cells or tissues. Typically, this assay will generate measurements of voltage changes or electric current (or other associated variables such as impedence or capacitance)." []
is_a: OBI:0000070 ! assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0002186
name: electroencephalography
def: "An extracellular electrophysiology assay where electrodes are mounted outside the brain (either on the surface of the scalp on onto the brain surface itself during surgery) to measure the electrical field over the external surface." []
subset: https://www.fairsharing.org
is_a: OBI:0000454 ! extracellular electrophysiology recording assay
property_value: IAO:0000118 "EEG" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0002438
name: nuclear ligation assay
def: "An assay that detects the proximity of chromosomal DNA through the use of a ligation reaction in isolated nuclei." []
is_a: OBI:0000070 ! assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0002567
name: sequence alignment
def: "A data transformation in which one or more sequences (reads) are positioned on a reference sequence template (often a reference set of genes), according to the genetic base-pairing paradigm." []
subset: https://www.fairsharing.org
is_a: OBI:0200187 ! sequence analysis data transformation
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0002692
name: polymerase chain reaction assay
def: "An assay that uses polymerase chain reaction technique to amplify DNA." []
is_a: OBI:0000070 ! assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0003117
name: 3D molecular structure determination assay
def: "An assay that determines the 3-dimensional configuration of a molecular entity or molecular complex." []
is_a: OBI:0600045 ! 3D structure determination assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0100014
name: chimera
def: "An organism which contains cells or tissues with a different genotype" []
subset: https://www.fairsharing.org
is_a: OBI:0100026 ! organism
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0100026
name: organism
def: "A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs." []
is_a: BFO:0000040 ! material entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0100051
name: specimen
def: "A material entity that is collected for potential use as an input upon which measurements or observations are performed." []
is_a: BFO:0000040 ! material entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0100060
name: cultured cell population
is_a: OBI:0000047 ! processed material
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl

[Term]
id: OBI:0200000
name: data transformation
def: "A planned process that produces output data from input data." []
subset: https://www.fairsharing.org
is_a: OBI:0000011 ! planned process
property_value: IAO:0000118 "data analysis" xsd:string
property_value: IAO:0000118 "data processing" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0200187
name: sequence analysis data transformation
def: "A sequence analysis data transformation is a data transformation that has objective sequence analysis and has the aim of analysing ordered biological data for sequential patterns." []
is_a: OBI:0200000 ! data transformation
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0300311
name: observation design
def: "observation design is a study design in which subjects are monitored in the absence of any active intervention by experimentalists." []
subset: https://www.fairsharing.org
is_a: OBI:0500000 ! study design
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0302840
name: curated information
def: "An information content entity that has undergone a digital curation performed by a curator for accuracy checks and compliance with curation requirements. Information which has been assessed for accuracy by domain experts." []
subset: https://www.fairsharing.org
is_a: IAO:0000030 ! information content entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0302900
name: group randomization
def: "A group assignment which relies on chance to assign materials to a group of materials in order to avoid bias in experimental set up." []
subset: https://www.fairsharing.org
is_a: OBI:0600015 ! group assignment
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0302903
name: nucleic acid hybridization
def: "a planned process by which totally or partially complementary, single-stranded nucleic acids are  combined into a single molecule called heteroduplex or homoduplex to an extent depending on the amount of complementarity." []
subset: https://www.fairsharing.org
is_a: OBI:0000094 ! material processing
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0302914
name: digital curation
def: "Digital curation is the process of establishing and developing long term repositories of digital assets for current and future reference by researchers, scientists, and historians, and scholars generally." []
subset: https://www.fairsharing.org
is_a: T4FS:0000141 ! data management
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0400147
name: microarray
def: "A processed material that is made to be used in an analyte assay. It consists of a physical immobilisation matrix in which substances that bind the analyte are placed in regular spatial position." []
is_a: OBI:0001865 ! assay array
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0400148
name: DNA microarray
def: "A DNA-microarray is a microarray that is used as a physical 2D immobilisation matrix for DNA sequences. DNA microarray-bound DNA fragments are used as targets for a hybridising probed sample." []
subset: https://www.fairsharing.org
is_a: OBI:0400147 ! microarray
property_value: IAO:0000118 "DNA Chip" xsd:string
property_value: IAO:0000118 "DNA-array" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0400169
name: microscope
def: "A microscope is an instrument which magnifies the view on objects (too small to be viewed by the naked eye) under increased resolution. A microscope can be an optical instrument but also and electronic instrument. There are various kind of optical microscopes, e.g confocal microscope, epifluoresence microscope)" []
is_a: OBI:0000398 ! image creation device
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0500000
name: study design
def: "A plan specification comprised of protocols (which may specify how and what kinds of data will be gathered) that are executed as part of an investigation and is realized during a study design execution." []
subset: https://www.fairsharing.org
is_a: IAO:0000104 ! plan specification
property_value: IAO:0000118 "experimental design" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0600002
name: tumor grading
def: "An assay that determines the grade (severity/stage) of a tumor sample, used in cancer biology to describe abnormalities/qualities of tumor cells or tissues. Values can be described by terms from NCI Thesaurus." []
subset: https://www.fairsharing.org
is_a: OBI:0000070 ! assay
property_value: IAO:0000118 "grading of tumor" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0600014
name: material component separation
def: "a material processing in which components of an input material become segregated in space" []
subset: https://www.fairsharing.org
is_a: OBI:0000094 ! material processing
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0600015
name: group assignment
def: "group assignment is a process which has an organism as specified input and during which a role is assigned" []
is_a: OBI:0000011 ! planned process
property_value: IAO:0000118 "cohort assignment" xsd:string
property_value: IAO:0000118 "study assignment" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0600017
name: assay detecting a molecular label
def: "An assay that detects the presence or a quality of a molecular label which is a proxy for the detection of the molecular target to which the label is attached" []
is_a: OBI:0000070 ! assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0600020
name: histological assay
def: "An assay that uses visual examination of cells or tissue (or images of them) to make an assessment regarding a quality of the cells or tissue. This assay can include steps of staining, imaging, and judgement." []
subset: https://www.fairsharing.org
is_a: OBI:0000070 ! assay
property_value: IAO:0000118 "histology" xsd:string
property_value: IAO:0000118 "histopathology" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0600045
name: 3D structure determination assay
def: "An assay that determines the 3-dimensional configuration of an input material." []
is_a: OBI:0000070 ! assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0600047
name: sequencing assay
def: "An assay the uses chemical or biochemical means to infer the sequence of a biomaterial" []
subset: https://www.fairsharing.org
is_a: OBI:0000070 ! assay
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0600053
name: electrophoresis
def: "a protocol application that uses an electrical potential to move material through a defined matrix in order to separate it by its resistance to movement and its charge" []
subset: https://www.fairsharing.org
is_a: OBI:0600014 ! material component separation
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0600056
name: protease cleavage
def: "protease cleavage is an enzymatic cleavage which relies on enzyme with protease activity to act on proteins and produce polypeptides (protein fragments)." []
subset: https://www.fairsharing.org
is_a: OBI:0000231 ! enzymatic cleavage
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0600058
name: enzymatic amplification
def: "the use of enzymes to increase the number of molecules of a biomaterial" []
is_a: OBI:0000094 ! material processing
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:1000049
name: whole mount tissue
def: "A whole organism preparation resulting from a histological preparation known as whole mount preparation where the whole specimen is mounted or spread on the microscope (glass) slide" []
subset: https://www.fairsharing.org
is_a: OBI:0000680 ! whole organism preparation
is_a: OBI:0000953 ! processed specimen
property_value: IAO:0000118 "whole mount sample" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:1110021
name: infection process
def: "the detrimental process in which an infectious agent colonizes or replicates in a host environment" []
subset: https://www.fairsharing.org
is_a: OBI:1110122 ! pathologic process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:1110108
name: material to be added
def: "A material entity that is added to another material entity in an “adding a material entity into a target” process." []
is_a: BFO:0000040 ! material entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:1110122
name: pathologic process
def: "abnormal, harmful processes caused by or associated with a disease" []
is_a: GO:0008150 ! biological_process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:1110201
name: allergen
def: "A material entity bearing the disposition to cause an allergic reaction" []
subset: https://www.fairsharing.org
is_a: BFO:0000040 ! material entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OGMS:0000023
name: phenotype
def: "A (combination of) quality(ies) of an organism determined by the interaction of its genetic make-up and environment that differentiates specific instances of a species from other instances of the same species." []
subset: https://www.fairsharing.org
is_a: BFO:0000019 ! quality
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl

[Term]
id: OGMS:0000028
name: disease phenotype
def: "A clinically abnormal phenotype that is characteristic of a single disease." []
subset: https://www.fairsharing.org
is_a: OGMS:0000023 ! phenotype
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl

[Term]
id: OGMS:0000031
name: disease
def: "A disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism." []
subset: https://www.fairsharing.org
is_a: BFO:0000016 ! disposition
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl

[Term]
id: OGMS:0000045
name: disorder
def: "A material entity which is clinically abnormal and part of an extended organism. Disorders are the physical basis of disease." []
subset: https://www.fairsharing.org
is_a: BFO:0000040 ! material entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl

[Term]
id: OGMS:0000063
name: disease course
def: "The totality of all processes through which a given disease instance is realized." []
subset: https://www.fairsharing.org
is_a: BFO:0000015 ! process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl

[Term]
id: OGMS:0000073
name: diagnosis
def: "The representation of a conclusion of a diagnostic process." []
subset: https://www.fairsharing.org
is_a: OGMS:0000123 ! clinical data item
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl

[Term]
id: OGMS:0000093
name: prognosis
def: "A hypothesis about some future part of a disease course." []
subset: https://www.fairsharing.org
is_a: IAO:0000027 ! data item
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl

[Term]
id: OGMS:0000123
name: clinical data item
def: "A data item that is about a patient and is the specified output of a health care process assay or diagnostic process" []
is_a: IAO:0000027 ! data item
property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl

[Term]
id: OMIT:0001480
name: Machine Learning
def: "Machine learning is an algorithm or set of algorithms which allows computers to learn and act like humans do, and improve their learning over time in autonomous fashion, by feeding them data and information in the form of observations and real-world interactions." []
comment: AL 26.6.18: This class is correctly added and placed by our automated procedures, but there is no definition within OMIT. Therefore we have manually assigned the included definition. This definition was adapted by AL from https://www.techemergence.com/what-is-machine-learning/
subset: https://www.fairsharing.org
is_a: IAO:0000064 ! algorithm
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omit.owl

[Term]
id: OMIT:0003072
name: Biotransformation
subset: https://www.fairsharing.org
is_a: GO:0008152 ! metabolic process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omit.owl

[Term]
id: OMIT:0004280
name: Classification
def: "The systematic arrangement of entities in any field into categories classes based on common characteristics such as properties, morphology, or subject matter." []
comment: AL 26.6.18: This class is correctly added and placed by our automated procedures, but there is no definition within OMIT. Therefore we have manually assigned the included definition. This definition was adapted by AL from https://meshb.nlm.nih.gov/record/ui?ui=D002965
subset: https://www.fairsharing.org
is_a: OBI:0200000 ! data transformation
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omit.owl

[Term]
id: OMIT:0008490
name: Interferons
subset: https://www.fairsharing.org
is_a: PR:000000001 ! protein
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omit.owl

[Term]
id: OMIT:0009360
name: Major Histocompatibility Complex
subset: https://www.fairsharing.org
is_a: GO:0032991 ! protein-containing complex
property_value: IAO:0000118 "MHC" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omit.owl

[Term]
id: OMIT:0010354
name: Natural Language Processing
subset: https://www.fairsharing.org
is_a: IAO:0000064 ! algorithm
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omit.owl

[Term]
id: OMIT:0012761
name: Radiation Effects
subset: https://www.fairsharing.org
is_a: NCIT:C41332 ! Adverse Reaction
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omit.owl

[Term]
id: OMIT:0014521
name: Teaching Materials
subset: https://www.fairsharing.org
is_a: IAO:0000030 ! information content entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omit.owl

[Term]
id: OMIT:0018868
name: Founder Effect
subset: https://www.fairsharing.org
is_a: SO:0001059 ! sequence_alteration
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omit.owl

[Term]
id: OMIT:0019234
name: Peptide Library
subset: https://www.fairsharing.org
is_a: BFO:0000040 ! material entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omit.owl

[Term]
id: OMIT:0019939
name: Benchmarking
subset: https://www.fairsharing.org
is_a: edam:operation_2945 ! Data analysis
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omit.owl

[Term]
id: OMIT:0020804
name: Quantitative Structure-Activity Relationship
subset: https://www.fairsharing.org
is_a: edam:operation_2945 ! Data analysis
property_value: IAO:0000118 "QSAR" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omit.owl

[Term]
id: OMIT:0025752
name: Receptors, KIR
subset: https://www.fairsharing.org
is_a: PR:000000001 ! protein
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omit.owl

[Term]
id: OMIT:0025926
name: Genome, Mitochondrial
subset: https://www.fairsharing.org
is_a: SO:0001026 ! genome
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omit.owl

[Term]
id: OMIT:0026082
name: Metagenome
subset: https://www.fairsharing.org
is_a: SO:0001260 ! sequence_collection
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omit.owl

[Term]
id: OMIT:0028181
name: Crowdsourcing
subset: https://www.fairsharing.org
is_a: efo:EFO_0002694 ! experimental process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omit.owl

[Term]
id: OMIT:0028415
name: Intrinsically Disordered Proteins
subset: https://www.fairsharing.org
is_a: PR:000000001 ! protein
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omit.owl

[Term]
id: OMIT:0028630
name: Non-Randomized Controlled Trials as Topic
subset: https://www.fairsharing.org
is_a: OBI:0000066 ! investigation
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omit.owl

[Term]
id: OMP:0000197
name: microbe-host interaction phenotype
def: "A microbial phenotype related to the interactions between a microbe and its host(s)." []
subset: https://www.fairsharing.org
is_a: OGMS:0000023 ! phenotype
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omp.owl

[Term]
id: OMRSE:00000056
name: hospital organization
def: "An organization that is the bearer of a hospital role." []
subset: https://www.fairsharing.org
is_a: OBI:0000245 ! organization
property_value: drao:DRAO_0000001 "Hospital" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/omrse.owl

[Term]
id: PATO:0000018
name: fluorescence
def: "A luminous flux quality inhering in a bearer by virtue of the bearer's emitting longer wavelength light following the absorption of shorter wavelength radiation; fluorescence is common with aromatic compounds with several rings joined together." []
subset: https://www.fairsharing.org
is_a: PATO:0001018 ! physical quality
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PATO:0000043
name: flavor
def: "A quality of a physical entity inhering in a bearer by virtue of whether the bearer's molecules are being perceived by a taste and odorant receptors." []
subset: https://www.fairsharing.org
is_a: PATO:0001018 ! physical quality
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PATO:0000049
name: intensity
def: "A quality inhering in a bearer by virtue of the bearer's possessing or displaying a distinctive feature in type or degree or effect or force." []
subset: https://www.fairsharing.org
is_a: PATO:0000068 ! qualitative
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PATO:0000051
name: morphology
def: "A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure." []
subset: https://www.fairsharing.org
is_a: PATO:0001241 ! physical object quality
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PATO:0000052
name: shape
def: "A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc)." []
subset: https://www.fairsharing.org
is_a: PATO:0000051 ! morphology
property_value: IAO:0000118 "relational shape quality" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PATO:0000058
name: odor
def: "A physical quality inhering in a bearer by virtue of the bearer's molecules being are aerially dispersed and perceived by an odorant receptor." []
subset: https://www.fairsharing.org
is_a: PATO:0001018 ! physical quality
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PATO:0000068
name: qualitative
def: "A quality of an entity that is descriptive or observational, typically not represented numerically." []
is_a: BFO:0000019 ! quality
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PATO:0000141
name: structure
def: "A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form." []
subset: https://www.fairsharing.org
is_a: PATO:0000051 ! morphology
property_value: IAO:0000118 "relational structural quality" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PATO:0001018
name: physical quality
def: "A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities." []
is_a: PATO:0001241 ! physical object quality
property_value: IAO:0000118 "relational physical quality" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PATO:0001021
name: energy
def: "A physical quality inhering in a bearer by virtue of the bearer's capacity to do work." []
is_a: PATO:0001018 ! physical quality
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PATO:0001241
name: physical object quality
def: "A quality which inheres in a continuant." []
is_a: BFO:0000019 ! quality
property_value: IAO:0000118 "monadic quality of a continuant" xsd:string
property_value: IAO:0000118 "monadic quality of an object" xsd:string
property_value: IAO:0000118 "monadic quality of continuant" xsd:string
property_value: IAO:0000118 "multiply inhering quality of a physical entity" xsd:string
property_value: IAO:0000118 "quality of a continuant" xsd:string
property_value: IAO:0000118 "quality of a single physical entity" xsd:string
property_value: IAO:0000118 "quality of an object" xsd:string
property_value: IAO:0000118 "quality of continuant" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PATO:0001415
name: morbidity
def: "A quality inhering in a population by virtue of the proportion of its members that are ill at a given time." []
subset: https://www.fairsharing.org
is_a: PATO:0001241 ! physical object quality
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PATO:0001884
name: hydrophobicity
def: "A physical quality inhering in a bearer by virtue the bearer's disposition to being water-repellent; tending to repel and not absorb water." []
subset: https://www.fairsharing.org
is_a: PATO:0001018 ! physical quality
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PATO:0001886
name: hydrophilicity
def: "A physical quality inhering in a bearer by virtue the bearer's disposition to having an affinity for water; it is readily absorbing or dissolving in water." []
subset: https://www.fairsharing.org
is_a: PATO:0001018 ! physical quality
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PATO:0001993
name: multicellular
def: "A cellularity quality inhering in a bearer by virtue of the bearer's consisting of more than one cell." []
subset: https://www.fairsharing.org
is_a: PATO:0001995 ! organismal quality
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PATO:0001995
name: organismal quality
def: "A quality that inheres in an entire organism or part of an organism." []
is_a: PATO:0001241 ! physical object quality
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PATO:0002070
name: affinity
def: "A molecular quality that arises from the molecular attraction exerted between two atoms or compounds." []
subset: https://www.fairsharing.org
is_a: PATO:0001241 ! physical object quality
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PATO:0002146
name: virulence
def: "A quality inhering in a bearer by virtue of the severity of infectious disease caused by the bearer in a target organism." []
subset: https://www.fairsharing.org
is_a: PATO:0001995 ! organismal quality
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PO:0007033
name: whole plant development stage
def: "A plant structure development stage (PO:0009012) that has as primary participant a whole plant (PO:0000003)." []
subset: https://www.fairsharing.org
is_a: UBERON:0000105 ! life cycle stage
property_value: IAO:0000412 http://purl.obolibrary.org/obo/po.owl

[Term]
id: PO:0009005
name: root
def: "A plant axis (PO:0025004) that lacks shoot axis nodes (PO:0005004) and usually grows indeterminately." []
subset: https://www.fairsharing.org
is_a: UBERON:0000061 ! anatomical structure
property_value: IAO:0000118 "aerial root (narrow)" xsd:string
property_value: IAO:0000118 "climbing root (narrow)" xsd:string
property_value: IAO:0000118 "ra&#237z (Spanish, exact)" xsd:string
property_value: IAO:0000118 "radices (exact, plural)" xsd:string
property_value: IAO:0000118 "radix (exact)" xsd:string
property_value: IAO:0000118 "根 (Japanese, exact)" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/po.owl

[Term]
id: PR:000000001
name: protein
def: "An amino acid chain that is canonically produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof." []
subset: https://www.fairsharing.org
is_a: CHEBI:25367 ! molecule
property_value: IAO:0000118 "native protein" xsd:string
property_value: IAO:0000118 "natural protein" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pr.owl

[Term]
id: PR:000037070
name: phosphoprotein
def: "A protein that includes at least one phosphorylated residue." []
subset: https://www.fairsharing.org
is_a: PR:000000001 ! protein
property_value: IAO:0000118 "phosphorylated protein" xsd:string
property_value: IAO:0000118 "Prot/PhosRes+" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pr.owl

[Term]
id: PRIDE:0000427
name: Top-down proteomics
def: "Top-down Proteomics is a method of protein identification that uses an ion trapping mass spectrometer to store an isolated protein ion for mass measurement and tandem mass spectrometry analysis. Top-down proteomics is capable of identifying unique proteoforms (the specific molecular form of the protein resulting from combinations of genetic variation, alternative splicing, and post-translational modifications) through the analysis of intact proteins. Both the intact and fragment ions masses of a protein can be measured. This approach routinely allows for 100% sequence coverage and full characterization of proteoforms. The potential for achieving full protein characterization has made the Top Down mass spectrometry approach extremely useful for analysis of single proteins or simple mixtures of significant biological interest." []
comment: Adapted by AL from https://dx.doi.org/10.1016%2Fj.bbrc.2014.02.041 and Wikipedia (https://en.wikipedia.org/wiki/Top-down_proteomics), 5.6.18
subset: https://www.fairsharing.org
is_a: OBI:0000470 ! mass spectrometry assay
property_value: IAO:0000412 pride:cv.obo

[Term]
id: PW:0000001
name: pathway
def: "A pathway is a set of inter-connected  reactions and interactions whose delineation and scope are used as a model for exploring and studying, describing and understanding the working of and relationships between biomolecules within a context." []
subset: https://www.fairsharing.org
is_a: IAO:0000030 ! information content entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pw.owl

[Term]
id: RO:0002577
name: system
def: "A material entity consisting of multiple components that are causally integrated." []
is_a: BFO:0000040 ! material entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl

[Term]
id: SO:0000001
name: region
def: "A sequence_feature with an extent greater than zero. A nucleotide region is composed of bases and a polypeptide region is composed of amino acids." []
subset: https://www.fairsharing.org
is_a: SO:0000110 ! sequence_feature
property_value: IAO:0000118 "sequence" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000101
name: transposable_element
def: "A transposon or insertion sequence. An element that can insert in a variety of DNA sequences." []
subset: https://www.fairsharing.org
is_a: SO:0001039 ! integrated_mobile_genetic_element
property_value: drao:DRAO_0000001 "transposable element" xsd:string
property_value: IAO:0000118 "transposable element" xsd:string
property_value: IAO:0000118 "transposon" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000110
name: sequence_feature
def: "Any extent of continuous biological sequence." []
subset: https://www.fairsharing.org
is_a: IAO:0000030 ! information content entity
property_value: drao:DRAO_0000001 "sequence feature" xsd:string
property_value: IAO:0000118 "INSDC_feature:misc_feature" xsd:string
property_value: IAO:0000118 "INSDC_note:other" xsd:string
property_value: IAO:0000118 "INSDC_note:sequence_feature" xsd:string
property_value: IAO:0000118 "located_sequence_feature" xsd:string
property_value: IAO:0000118 "sequence feature" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000112
name: primer
def: "An oligo to which new deoxyribonucleotides can be added by DNA polymerase." []
subset: https://www.fairsharing.org
is_a: SO:0000696 ! oligo
property_value: IAO:0000118 "DNA primer" xsd:string
property_value: IAO:0000118 "primer oligonucleotide" xsd:string
property_value: IAO:0000118 "primer polynucleotide" xsd:string
property_value: IAO:0000118 "primer sequence" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000143
name: assembly_component
def: "A region of known length which may be used to manufacture a longer region." []
is_a: SO:0001410 ! experimental_feature
property_value: IAO:0000118 "assembly component" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000147
name: exon
def: "A region of the transcript sequence within a gene which is not removed from the primary RNA transcript by RNA splicing." []
subset: https://www.fairsharing.org
is_a: SO:0000833 ! transcript_region
property_value: IAO:0000118 "INSDC_feature:exon" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000149
name: contig
def: "A contiguous sequence derived from sequence assembly. Has no gaps, but may contain N's from unavailable bases." []
subset: https://www.fairsharing.org
is_a: SO:0000143 ! assembly_component
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000150
name: read
def: "A sequence obtained from a single sequencing experiment. Typically a read is produced when a base calling program interprets information from a chromatogram trace file produced from a sequencing machine." []
subset: https://www.fairsharing.org
is_a: SO:0000143 ! assembly_component
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000162
name: splice_site
def: "Consensus region of primary transcript bordering junction of splicing. A region that overlaps exactly 2 base and adjacent_to splice_junction." []
subset: https://www.fairsharing.org
is_a: SO:0000835 ! primary_transcript_region
property_value: drao:DRAO_0000001 "splice site" xsd:string
property_value: IAO:0000118 "splice site" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000167
name: promoter
def: "A regulatory_region composed of the TSS(s) and binding sites for TF_complexes of the core transcription machinery. A region (DNA) to which RNA polymerase binds, to begin transcription." []
subset: https://www.fairsharing.org
is_a: SO:0005836 ! regulatory_region
property_value: IAO:0000118 "INSDC_qualifier:promoter" xsd:string
property_value: IAO:0000118 "promoter sequence" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000178
name: operon
def: "The DNA region of a group of adjacent genes whose transcription is coordinated on one or several mutually overlapping transcription units transcribed in the same direction and sharing at least one gene." []
subset: https://www.fairsharing.org
is_a: SO:0005855 ! gene_group
property_value: IAO:0000118 "INSDC_feature:operon" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000180
name: retrotransposon
def: "A transposable element that is incorporated into a chromosome by a mechanism that requires reverse transcriptase." []
subset: https://www.fairsharing.org
is_a: SO:0000101 ! transposable_element
property_value: IAO:0000118 "class I transposon" xsd:string
property_value: IAO:0000118 "retrotransposon element" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000182
name: DNA_transposon
def: "A transposon where the mechanism of transposition is via a DNA intermediate." []
is_a: SO:0000101 ! transposable_element
property_value: IAO:0000118 "class II transposon" xsd:string
property_value: IAO:0000118 "DNA transposon" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000188
name: intron
def: "A region of a primary transcript that is transcribed, but removed from within the transcript by splicing together the sequences (exons) on either side of it." []
subset: https://www.fairsharing.org
is_a: SO:0000835 ! primary_transcript_region
property_value: IAO:0000118 "INSDC_feature:intron" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000203
name: UTR
def: "Messenger RNA sequences that are untranslated and lie five prime or three prime to sequences which are translated." []
subset: https://www.fairsharing.org
is_a: SO:0000836 ! mRNA_region
property_value: IAO:0000118 "untranslated region" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000233
name: mature_transcript
def: "A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified." []
is_a: SO:0000673 ! transcript
property_value: IAO:0000118 "mature transcript" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000234
name: mRNA
def: "Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns." []
subset: https://www.fairsharing.org
is_a: SO:0000233 ! mature_transcript
property_value: IAO:0000118 "INSDC_feature:mRNA" xsd:string
property_value: IAO:0000118 "messenger RNA" xsd:string
property_value: IAO:0000118 "protein_coding_transcript" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000239
name: flanking_region
def: "The sequences extending on either side of a specific region." []
subset: https://www.fairsharing.org
is_a: SO:0000001 ! region
property_value: drao:DRAO_0000001 "flanking region" xsd:string
property_value: IAO:0000118 "flanking region" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000243
name: internal_ribosome_entry_site
def: "Sequence element that recruits a ribosomal subunit to internal mRNA for translation initiation." []
subset: https://www.fairsharing.org
is_a: SO:0000836 ! mRNA_region
property_value: drao:DRAO_0000001 "internal ribosome entry site" xsd:string
property_value: IAO:0000118 "internal ribosomal entry sequence" xsd:string
property_value: IAO:0000118 "internal ribosomal entry site" xsd:string
property_value: IAO:0000118 "internal ribosome entry site" xsd:string
property_value: IAO:0000118 "IRES" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000253
name: tRNA
def: "Transfer RNA (tRNA) molecules are approximately 80 nucleotides in length. Their secondary structure includes four short double-helical elements and three loops (D, anti-codon, and T loops). Further hydrogen bonds mediate the characteristic L-shaped molecular structure. Transfer RNAs have two regions of fundamental functional importance: the anti-codon, which is responsible for specific mRNA codon recognition, and the 3' end, to which the tRNA's corresponding amino acid is attached (by aminoacyl-tRNA synthetases). Transfer RNAs cope with the degeneracy of the genetic code in two manners: having more than one tRNA (with a specific anti-codon) for a particular amino acid; and 'wobble' base-pairing, i.e. permitting non-standard base-pairing at the 3rd anti-codon position." []
subset: https://www.fairsharing.org
is_a: SO:0002247 ! sncRNA
property_value: IAO:0000118 "INSDC_feature:tRNA" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000276
name: miRNA
def: "Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene (or the product of other non coding RNA genes). Micro RNAs are produced from precursor molecules (SO:0001244) that can form local hairpin structures, which ordinarily are processed (usually via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors." []
subset: https://www.fairsharing.org
is_a: SO:0000370 ! small_regulatory_ncRNA
property_value: IAO:0000118 "INSDC_qualifier:miRNA" xsd:string
property_value: IAO:0000118 "micro RNA" xsd:string
property_value: IAO:0000118 "microRNA" xsd:string
property_value: IAO:0000118 "small temporal RNA" xsd:string
property_value: IAO:0000118 "stRNA" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000289
name: microsatellite
def: "A repeat_region containing repeat_units of 2 to 10 bp repeated in tandem." []
subset: https://www.fairsharing.org
is_a: SO:0000705 ! tandem_repeat
property_value: IAO:0000118 "INSDC_qualifier:microsatellite" xsd:string
property_value: IAO:0000118 "microsatellite locus" xsd:string
property_value: IAO:0000118 "microsatellite marker" xsd:string
property_value: IAO:0000118 "short tandem repeat" xsd:string
property_value: IAO:0000118 "STR" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000312
name: experimentally_determined
def: "Attribute to describe a feature that has been experimentally verified." []
subset: https://www.fairsharing.org
is_a: SO:0000733 ! feature_attribute
property_value: drao:DRAO_0000001 "experimentally determined" xsd:string
property_value: IAO:0000118 "experimentally determined" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000316
name: CDS
def: "A contiguous sequence which begins with, and includes, a start codon and ends with, and includes, a stop codon." []
subset: https://www.fairsharing.org
is_a: SO:0000836 ! mRNA_region
property_value: IAO:0000118 "coding sequence" xsd:string
property_value: IAO:0000118 "coding_sequence" xsd:string
property_value: IAO:0000118 "INSDC_feature:CDS" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000324
name: tag
def: "A nucleotide sequence that may be used to identify a larger sequence." []
subset: https://www.fairsharing.org
is_a: SO:0000696 ! oligo
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000330
name: conserved_region
def: "Region of sequence similarity by descent from a common ancestor." []
subset: https://www.fairsharing.org
is_a: SO:0001410 ! experimental_feature
property_value: drao:DRAO_0000001 "conserved region" xsd:string
property_value: IAO:0000118 "conserved region" xsd:string
property_value: IAO:0000118 "INSDC_note:conserved_region" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000336
name: pseudogene
def: "A sequence that closely resembles a known functional gene, at another locus within a genome, that is non-functional as a consequence of (usually several) mutations that prevent either its transcription or translation (or both). In general, pseudogenes result from either reverse transcription of a transcript of their \"normal\" paralog (SO:0000043) (in which case the pseudogene typically lacks introns and includes a poly(A) tail) or from recombination (SO:0000044) (in which case the pseudogene is typically a tandem duplication of its \"normal\" paralog)." []
subset: https://www.fairsharing.org
is_a: SO:0001411 ! biological_region
property_value: IAO:0000118 "INSDC_qualifier:pseudo" xsd:string
property_value: IAO:0000118 "INSDC_qualifier:unknown" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000370
name: small_regulatory_ncRNA
def: "A non-coding RNA less than 200 nucleotides long, usually with a specific secondary structure, that acts to regulate gene expression. These include short ncRNAs such as piRNA, miRNA and siRNAs (among others)." []
is_a: SO:0002247 ! sncRNA
property_value: IAO:0000118 "small regulatory ncRNA" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000371
name: conjugative_transposon
def: "A transposon that encodes function required for conjugation." []
subset: https://www.fairsharing.org
is_a: SO:0000182 ! DNA_transposon
property_value: drao:DRAO_0000001 "conjugative transposon" xsd:string
property_value: IAO:0000118 "conjugative transposon" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000400
name: sequence_attribute
def: "An attribute describes a quality of sequence." []
is_a: BFO:0000019 ! quality
property_value: IAO:0000118 "sequence attribute" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000409
name: binding_site
def: "A biological_region of sequence that, in the molecule, interacts selectively and non-covalently with other molecules. A region on the surface of a molecule that may interact with another molecule. When applied to polypeptides: Amino acids involved in binding or interactions. It can also apply to an amino acid bond which is represented by the positions of the two flanking amino acids." []
subset: https://www.fairsharing.org
is_a: SO:0001411 ! biological_region
property_value: drao:DRAO_0000001 "binding site" xsd:string
property_value: IAO:0000118 "binding site" xsd:string
property_value: IAO:0000118 "binding_or_interaction_site" xsd:string
property_value: IAO:0000118 "INSDC_feature:misc_binding" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000418
name: signal_peptide
def: "The signal_peptide is a short region of the peptide located at the N-terminus that directs the protein to be secreted or part of membrane components." []
subset: https://www.fairsharing.org
is_a: SO:0000839 ! polypeptide_region
property_value: drao:DRAO_0000001 "signal peptide" xsd:string
property_value: IAO:0000118 "INSDC_feature:sig_peptide" xsd:string
property_value: IAO:0000118 "signal peptide" xsd:string
property_value: IAO:0000118 "signal peptide coding sequence" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000436
name: ARS
def: "A sequence that can autonomously replicate, as a plasmid, when transformed into a bacterial host." []
subset: https://www.fairsharing.org
is_a: SO:0001411 ! biological_region
property_value: IAO:0000118 "autonomously replicating sequence" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000591
name: pseudoknot
def: "A tertiary structure in RNA where nucleotides in a loop form base pairs with a region of RNA downstream of the loop." []
subset: https://www.fairsharing.org
is_a: SO:0001411 ! biological_region
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000603
name: group_II_intron
def: "Group II introns are found in rRNA, tRNA and mRNA of organelles in fungi, plants and protists, and also in mRNA in bacteria. They are large self-splicing ribozymes and have 6 structural domains (usually designated dI to dVI). A subset of group II introns also encode essential splicing proteins in intronic ORFs. The length of these introns can therefore be up to 3kb. Splicing occurs in almost identical fashion to nuclear pre-mRNA splicing with two transesterification steps. The 2' hydroxyl of a bulged adenosine in domain VI attacks the 5' splice site, followed by nucleophilic attack on the 3' splice site by the 3' OH of the upstream exon. Protein machinery is required for splicing in vivo, and long range intron to intron and intron-exon interactions are important for splice site positioning. Group II introns are further sub-classified into groups IIA and IIB which differ in splice site consensus, distance of bulged A from 3' splice site, some tertiary interactions, and intronic ORF phylogeny." []
subset: https://www.fairsharing.org
is_a: SO:0000188 ! intron
property_value: drao:DRAO_0000001 "group II intron" xsd:string
property_value: IAO:0000118 "group II intron" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000646
name: siRNA
def: "A small RNA molecule that is the product of a longer exogenous or endogenous dsRNA, which is either a bimolecular duplex or very long hairpin, processed (via the Dicer pathway) such that numerous siRNAs accumulate from both strands of the dsRNA. siRNAs trigger the cleavage of their target molecules." []
subset: https://www.fairsharing.org
is_a: SO:0000370 ! small_regulatory_ncRNA
property_value: IAO:0000118 "INSDC_qualifier:siRNA" xsd:string
property_value: IAO:0000118 "small interfering RNA" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000655
name: ncRNA
def: "An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product." []
subset: https://www.fairsharing.org
is_a: SO:0000233 ! mature_transcript
property_value: IAO:0000118 "known_ncrna" xsd:string
property_value: IAO:0000118 "noncoding RNA" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000657
name: repeat_region
def: "A region of sequence containing one or more repeat units." []
is_a: SO:0001411 ! biological_region
property_value: IAO:0000118 "INSDC_qualifier:other" xsd:string
property_value: IAO:0000118 "repeat region" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000667
name: insertion
def: "The sequence of one or more nucleotides added between two adjacent nucleotides in the sequence." []
subset: https://www.fairsharing.org
is_a: SO:0001059 ! sequence_alteration
is_a: SO:0001411 ! biological_region
property_value: IAO:0000118 "insertion" xsd:string
property_value: IAO:0000118 "nucleotide insertion" xsd:string
property_value: IAO:0000118 "nucleotide_insertion" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000673
name: transcript
def: "An RNA synthesized on a DNA or RNA template by an RNA polymerase." []
subset: https://www.fairsharing.org
is_a: SO:0000831 ! gene_member_region
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000694
name: SNP
def: "SNPs are single base pair positions in genomic DNA at which different sequence alternatives exist in normal individuals in some population(s), wherein the least frequent variant has an abundance of 1% or greater." []
subset: https://www.fairsharing.org
is_a: SO:0001483 ! SNV
property_value: IAO:0000118 "single nucleotide polymorphism" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000696
name: oligo
def: "A short oligonucleotide sequence, of length on the order of 10's of bases; either single or double stranded." []
is_a: SO:0000001 ! region
property_value: IAO:0000118 "oligonucleotide" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000704
name: gene
def: "A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions." []
subset: https://www.fairsharing.org
is_a: SO:0001411 ! biological_region
property_value: IAO:0000118 "INSDC_feature:gene" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000705
name: tandem_repeat
def: "Two or more adjacent copies of a region (of length greater than 1)." []
subset: https://www.fairsharing.org
is_a: SO:0000657 ! repeat_region
property_value: drao:DRAO_0000001 "tandem repeat" xsd:string
property_value: IAO:0000118 "INSDC_qualifier:tandem" xsd:string
property_value: IAO:0000118 "tandem repeat" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000733
name: feature_attribute
def: "An attribute describing a located_sequence_feature." []
is_a: SO:0000400 ! sequence_attribute
property_value: IAO:0000118 "feature attribute" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000736
name: organelle_sequence
def: "A sequence of DNA that originates from a an organelle." []
is_a: SO:0000400 ! sequence_attribute
property_value: IAO:0000118 "organelle sequence" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000737
name: mitochondrial_sequence
def: "DNA belonging to the genome of a mitochondria." []
subset: https://www.fairsharing.org
is_a: SO:0000736 ! organelle_sequence
property_value: drao:DRAO_0000001 "mitochondrial sequence" xsd:string
property_value: IAO:0000118 "mitochondrial sequence" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000740
name: plastid_sequence
def: "DNA belonging to the genome of a plastid such as a chloroplast." []
subset: https://www.fairsharing.org
is_a: SO:0000736 ! organelle_sequence
property_value: drao:DRAO_0000001 "plastid sequence" xsd:string
property_value: IAO:0000118 "plastid sequence" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000745
name: chloroplast_sequence
def: "DNA belonging to the genome of a chloroplast, a green plastid for photosynthesis." []
subset: https://www.fairsharing.org
is_a: SO:0000740 ! plastid_sequence
property_value: drao:DRAO_0000001 "chloroplast sequence" xsd:string
property_value: IAO:0000118 "chloroplast sequence" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000756
name: cDNA
def: "DNA synthesized by reverse transcriptase using RNA as a template." []
subset: https://www.fairsharing.org
is_a: CHEBI:16991 ! deoxyribonucleic acid
property_value: IAO:0000118 "complementary DNA" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000771
name: QTL
def: "A quantitative trait locus (QTL) is a polymorphic locus which contains alleles that differentially affect the expression of a continuously distributed phenotypic trait. Usually it is a marker described by statistical association to quantitative variation in the particular phenotypic trait that is thought to be controlled by the cumulative action of alleles at multiple loci." []
subset: https://www.fairsharing.org
is_a: SO:0001411 ! biological_region
property_value: IAO:0000118 "quantitative trait locus" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000772
name: genomic_island
def: "A genomic island is an integrated mobile genetic element, characterized by size (over 10 Kb). It that has features that suggest a foreign origin. These can include nucleotide distribution (oligonucleotides signature, CG content etc.) that differs from the bulk of the chromosome and/or genes suggesting DNA mobility." []
subset: https://www.fairsharing.org
is_a: SO:0001039 ! integrated_mobile_genetic_element
property_value: drao:DRAO_0000001 "genomic island" xsd:string
property_value: IAO:0000118 "genomic island" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000831
name: gene_member_region
def: "A region of a gene." []
is_a: SO:0001411 ! biological_region
property_value: IAO:0000118 "gene member region" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000833
name: transcript_region
def: "A region of a transcript." []
is_a: SO:0001411 ! biological_region
property_value: IAO:0000118 "transcript region" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000835
name: primary_transcript_region
def: "A part of a primary transcript." []
is_a: SO:0000833 ! transcript_region
property_value: IAO:0000118 "primary transcript region" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000836
name: mRNA_region
def: "A region of an mRNA." []
is_a: SO:0000833 ! transcript_region
property_value: IAO:0000118 "mRNA region" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000839
name: polypeptide_region
def: "Biological sequence region that can be assigned to a specific subsequence of a polypeptide." []
subset: https://www.fairsharing.org
is_a: SO:0001411 ! biological_region
property_value: drao:DRAO_0000001 "polypeptide region" xsd:string
property_value: IAO:0000118 "Protein sequence" xsd:string
property_value: IAO:0000118 "region" xsd:string
property_value: IAO:0000118 "site" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000857
name: homologous
def: "Similarity due to common ancestry." []
subset: https://www.fairsharing.org
is_a: SO:0000733 ! feature_attribute
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000858
name: orthologous
def: "An attribute describing a kind of homology where divergence occurred after a speciation event." []
subset: https://www.fairsharing.org
is_a: SO:0000857 ! homologous
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000859
name: paralogous
def: "An attribute describing a kind of homology where divergence occurred after a duplication event." []
subset: https://www.fairsharing.org
is_a: SO:0000857 ! homologous
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000870
name: trans_spliced
def: "An attribute describing transcript sequence that is created by splicing exons from diferent genes." []
subset: https://www.fairsharing.org
is_a: SO:0000733 ! feature_attribute
property_value: drao:DRAO_0000001 "trans spliced" xsd:string
property_value: IAO:0000118 "trans-spliced" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000934
name: miRNA_target_site
def: "A miRNA target site is a binding site where the molecule is a micro RNA." []
subset: https://www.fairsharing.org
is_a: SO:0000409 ! binding_site
property_value: drao:DRAO_0000001 "miRNA target site" xsd:string
property_value: IAO:0000118 "miRNA target site" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0000973
name: insertion_sequence
def: "A terminal_inverted_repeat_element that is bacterial and only encodes the functions required for its transposition between these inverted repeats." []
subset: https://www.fairsharing.org
is_a: SO:0000182 ! DNA_transposon
property_value: drao:DRAO_0000001 "insertion sequence" xsd:string
property_value: IAO:0000118 "insertion sequence" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001000
name: cytosolic_16S_rRNA
def: "Cytosolic 16S rRNA is an RNA component of the small subunit of cytosolic ribosomes in prokaryotes." []
subset: https://www.fairsharing.org
is_a: SO:0000655 ! ncRNA
property_value: drao:DRAO_0000001 "cystolic 16S rRNA" xsd:string
property_value: IAO:0000118 "cytosolic 16S ribosomal RNA" xsd:string
property_value: IAO:0000118 "cytosolic 16S SSU RNA" xsd:string
property_value: IAO:0000118 "cytosolic rRNA 16S" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001006
name: prophage
def: "A phage genome after it has established in the host genome in a latent/immune state either as a plasmid or as an integrated \"island\"." []
subset: https://www.fairsharing.org
is_a: SO:0001039 ! integrated_mobile_genetic_element
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001007
name: cryptic_prophage
def: "A remnant of an integrated prophage in the host genome or an \"island\" in the host genome that includes phage like-genes." []
subset: https://www.fairsharing.org
is_a: SO:0000772 ! genomic_island
property_value: drao:DRAO_0000001 "cryptic prophage" xsd:string
property_value: IAO:0000118 "cryptic prophage" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001021
name: chromosome_breakpoint
def: "A chromosomal region that may sustain a double-strand break, resulting in a recombination event." []
subset: https://www.fairsharing.org
is_a: SO:0000110 ! sequence_feature
property_value: drao:DRAO_0000001 "chromosome breakpoint" xsd:string
property_value: IAO:0000118 "aberration breakpoint" xsd:string
property_value: IAO:0000118 "aberration_junction" xsd:string
property_value: IAO:0000118 "chromosome breakpoint" xsd:string
property_value: IAO:0000118 "INSDC_qualifier:chromosome_breakpoint" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001023
name: allele
def: "An allele is one of a set of coexisting sequence variants of a gene." []
subset: https://www.fairsharing.org
is_a: SO:0001260 ! sequence_collection
property_value: IAO:0000118 "allelomorph" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001026
name: genome
def: "A genome is the sum of genetic material within a cell or virion." []
subset: https://www.fairsharing.org
is_a: SO:0001260 ! sequence_collection
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001037
name: mobile_genetic_element
def: "A nucleotide region with either intra-genome or intracellular mobility, of varying length, which often carry the information necessary for transfer and recombination with the host genome." []
subset: https://www.fairsharing.org
is_a: SO:0001411 ! biological_region
property_value: drao:DRAO_0000001 "mobile genetic element" xsd:string
property_value: IAO:0000118 "INSDC_feature:mobile_element" xsd:string
property_value: IAO:0000118 "MGE" xsd:string
property_value: IAO:0000118 "mobile genetic element" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001039
name: integrated_mobile_genetic_element
def: "An MGE that is integrated into the host chromosome." []
is_a: SO:0001037 ! mobile_genetic_element
property_value: IAO:0000118 "integrated mobile genetic element" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001041
name: viral_sequence
def: "The region of nucleotide sequence of a virus, a submicroscopic particle that replicates by infecting a host cell." []
subset: https://www.fairsharing.org
is_a: SO:0001037 ! mobile_genetic_element
property_value: drao:DRAO_0000001 "viral sequence" xsd:string
property_value: IAO:0000118 "viral sequence" xsd:string
property_value: IAO:0000118 "virus sequence" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001059
name: sequence_alteration
def: "A sequence_alteration is a sequence_feature whose extent is the deviation from another sequence." []
subset: https://www.fairsharing.org
is_a: SO:0000110 ! sequence_feature
property_value: drao:DRAO_0000001 "sequence alteration" xsd:string
property_value: IAO:0000118 "INSDC_feature:variation" xsd:string
property_value: IAO:0000118 "INSDC_note:sequence_alteration" xsd:string
property_value: IAO:0000118 "partially characterised change in DNA sequence" xsd:string
property_value: IAO:0000118 "partially_characterised_change_in_DNA_sequence" xsd:string
property_value: IAO:0000118 "sequence alteration" xsd:string
property_value: IAO:0000118 "uncharacterised_change_in_nucleotide_sequence" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001060
name: sequence_variant
def: "A sequence_variant is a non exact copy of a sequence_feature or genome exhibiting one or more sequence_alteration." []
subset: https://www.fairsharing.org
is_a: SO:0000110 ! sequence_feature
property_value: drao:DRAO_0000001 "sequence variant" xsd:string
property_value: IAO:0000118 "Jannovar:sequence_variant" xsd:string
property_value: IAO:0000118 "sequence variant" xsd:string
property_value: IAO:0000118 "VAAST:sequence_variant" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001067
name: polypeptide_motif
def: "A sequence motif is a short (up to 20 amino acids) region of biological interest. Such motifs, although they are too short to constitute functional domains, share sequence similarities and are conserved in different proteins. They display a common function (protein-binding, subcellular location etc.)." []
subset: https://www.fairsharing.org
is_a: SO:0000839 ! polypeptide_region
property_value: drao:DRAO_0000001 "polypeptide motif" xsd:string
property_value: IAO:0000118 "polypeptide motif" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001244
name: pre_miRNA
def: "The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin structure." []
subset: https://www.fairsharing.org
is_a: SO:0000835 ! primary_transcript_region
property_value: drao:DRAO_0000001 "pre miRNA" xsd:string
property_value: IAO:0000118 "pre-miRNA" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001260
name: sequence_collection
def: "A collection of discontinuous sequences." []
is_a: IAO:0000030 ! information content entity
property_value: IAO:0000118 "sequence collection" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001410
name: experimental_feature
def: "A region which is the result of some arbitrary experimental procedure. The procedure may be carried out with biological material or inside a computer." []
is_a: SO:0000001 ! region
property_value: IAO:0000118 "experimental output artefact" xsd:string
property_value: IAO:0000118 "experimental_output_artefact" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001411
name: biological_region
def: "A region defined by its disposition to be involved in a biological process." []
is_a: SO:0000001 ! region
property_value: IAO:0000118 "biological region" xsd:string
property_value: IAO:0000118 "INSDC_note:biological_region" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001459
name: CRISPR
def: "Clustered Palindromic Repeats interspersed with bacteriophage derived spacer sequences." []
subset: https://www.fairsharing.org
is_a: SO:0000657 ! repeat_region
property_value: IAO:0000118 "Clustered_Regularly_Interspaced_Short_Palindromic_Repeat" xsd:string
property_value: IAO:0000118 "CRISPR element" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001483
name: SNV
def: "SNVs are single nucleotide positions in genomic DNA at which different sequence alternatives exist." []
is_a: SO:1000002 ! substitution
property_value: IAO:0000118 "single nucleotide variant" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001505
name: reference_genome
def: "A collection of sequences (often chromosomes) taken as the standard for a given organism and genome assembly." []
subset: https://www.fairsharing.org
is_a: SO:0001026 ! genome
property_value: drao:DRAO_0000001 "reference genome" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001683
name: sequence_motif
def: "A sequence motif is a nucleotide or amino-acid sequence pattern that may have biological significance." []
subset: https://www.fairsharing.org
is_a: SO:0001411 ! biological_region
property_value: drao:DRAO_0000001 "sequence motif" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001877
name: lncRNA
def: "A non-coding RNA generally longer than 200 nucleotides that cannot be classified as any other ncRNA subtype. Similar to mRNAs, lncRNAs are mainly transcribed by RNA polymerase II, are often capped by 7-methyl guanosine at their 5' ends, polyadenylated at their 3' ends and may be spliced." []
subset: https://www.fairsharing.org
is_a: SO:0000655 ! ncRNA
property_value: IAO:0000118 "INSDC_qualifier:lncRNA" xsd:string
property_value: IAO:0000118 "lncRNA" xsd:string
property_value: IAO:0000118 "lncRNA_transcript" xsd:string
property_value: IAO:0000118 "long non-coding RNA" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0001956
name: protease_site
def: "A polypeptide_region that codes for a protease cleavage site." []
subset: https://www.fairsharing.org
is_a: SO:0000839 ! polypeptide_region
property_value: drao:DRAO_0000001 "protease site" xsd:string
property_value: IAO:0000118 "protease site" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0002031
name: shRNA
def: "A short hairpin RNA (shRNA) is an RNA transcript that makes a tight hairpin turn that can be used to silence target gene expression via RNA interference." []
subset: https://www.fairsharing.org
is_a: SO:0000655 ! ncRNA
property_value: IAO:0000118 "short hairpin RNA" xsd:string
property_value: IAO:0000118 "small hairpin RNA" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0002096
name: short_tandem_repeat_variation
def: "A variation that expands or contracts a tandem repeat with regard to a reference." []
subset: https://www.fairsharing.org
is_a: SO:0001059 ! sequence_alteration
property_value: drao:DRAO_0000001 "short tandem repeat variation" xsd:string
property_value: IAO:0000118 "short tandem repeat variation" xsd:string
property_value: IAO:0000118 "str variation" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0002247
name: sncRNA
def: "A non-coding RNA less than 200 nucleotides in length." []
is_a: SO:0000655 ! ncRNA
property_value: IAO:0000118 "Small noncoding RNA" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0005836
name: regulatory_region
def: "A region of sequence that is involved in the control of a biological process." []
subset: https://www.fairsharing.org
is_a: SO:0000831 ! gene_member_region
property_value: drao:DRAO_0000001 "regulatory region" xsd:string
property_value: IAO:0000118 "INSDC_qualifier:other" xsd:string
property_value: IAO:0000118 "regulatory region" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0005851
name: gene_array
def: "An array includes two or more genes, or two or more gene subarrays, contiguously arranged where the individual genes, or subarrays, are either identical in sequence, or essentially so." []
subset: https://www.fairsharing.org
is_a: SO:0005855 ! gene_group
property_value: drao:DRAO_0000001 "gene array" xsd:string
property_value: IAO:0000118 "gene array" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:0005855
name: gene_group
def: "A collection of related genes." []
is_a: SO:0001411 ! biological_region
property_value: IAO:0000118 "gene group" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:1000002
name: substitution
def: "A sequence alteration where the length of the change in the variant is the same as that of the reference." []
is_a: SO:0001059 ! sequence_alteration
is_a: SO:0001411 ! biological_region
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:1000008
name: point_mutation
def: "A single nucleotide change which has occurred at the same position of a corresponding nucleotide in a reference sequence." []
subset: https://www.fairsharing.org
is_a: SO:0001483 ! SNV
property_value: drao:DRAO_0000001 "point mutation" xsd:string
property_value: IAO:0000118 "point mutation" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:1000032
name: delins
def: "A sequence alteration which included an insertion and a deletion, affecting 2 or more bases." []
subset: https://www.fairsharing.org
is_a: SO:0001059 ! sequence_alteration
property_value: IAO:0000118 "deletion-insertion" xsd:string
property_value: IAO:0000118 "indel" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:1000035
name: duplication
def: "An insertion which derives from, or is identical in sequence to, nucleotides present at a known location in the genome." []
subset: https://www.fairsharing.org
is_a: SO:0000667 ! insertion
property_value: IAO:0000118 "nucleotide duplication" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: SO:1000183
name: chromosome_structure_variation
def: "An alteration of the genome that leads to a change in the structure or number of one or more chromosomes." []
subset: https://www.fairsharing.org
is_a: NCIT:C17004 ! Genetic Polymorphism
property_value: drao:DRAO_0000001 "chromosome structure variation" xsd:string
property_value: IAO:0000118 "chromosome structure variation" xsd:string
property_value: IAO:0000118 "snpEff:CHROMOSOME_LARGE_DELETION" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl

[Term]
id: STATO:0000039
name: statistic
def: "a statistic is a measurement datum to describe a dataset or a variable. It is generated by a calculation on set of observed data." []
is_a: IAO:0000027 ! data item
property_value: IAO:0000118 "statistic" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/stato.owl

[Term]
id: STATO:0000091
name: genome-wide association study
def: "Genome wide association study is a kind of study whose objective is to detect association between genetic markers (SNP or otherwise) accross the genome and a trait which may be a disease or another phenotype (e.g. trait of agronomic relevance in animal or plant studies). Genome wide association study compare the allele frequencies in 2 populations, one free of the trait used as control, the other one showing the trait use as 'case'. GWAS studies implement case-control design" []
subset: https://www.fairsharing.org
is_a: STATO:0000235 ! genetic association study
property_value: IAO:0000118 "" xsd:string
property_value: IAO:0000118 "GWAS study" xsd:string
property_value: IAO:0000118 "whole genome association study" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/stato.owl

[Term]
id: STATO:0000184
name: ratio
def: "A ratio is a data item which is formed with two numbers r and s is written r/s, where r is the numerator and s is the denominator. The ratio of r to s is equivalent to the quotient r/s." []
is_a: STATO:0000039 ! statistic
property_value: IAO:0000412 http://purl.obolibrary.org/obo/stato.owl

[Term]
id: STATO:0000235
name: genetic association study
def: "A genetic association study is a kind of study whose objective is to detect associations between phenotypes, between a phenotype and a genetic polymorphism or between two genetic polymorphisms." []
is_a: OBI:0000066 ! investigation
property_value: IAO:0000412 http://purl.obolibrary.org/obo/stato.owl

[Term]
id: STATO:0000254
name: allele frequency
def: "The allele frequency is a data item which denotes the incidence of a gene variant in a population. It is calculated as a ratio, by dividing the number of copies of a particular allele by the number of copies of all alleles at the genetic place (locus) in a population." []
subset: https://www.fairsharing.org
is_a: STATO:0000184 ! ratio
property_value: IAO:0000118 "gene frequency" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/stato.owl

[Term]
id: T4FS:0000012
name: data stewardship activity
def: "A specific deed, action, function or sphere of action in relation with the role of data stewardship" []
is_a: BFO:0000015 ! process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/t4fs.owl

[Term]
id: T4FS:0000141
name: data management
def: "The activities of data policies, data planning, data element standardization, information management control, data synchronization, data sharing, and database development, including practices and projects that acquire, control, protect, deliver and enhance the value of data and information." []
subset: https://www.fairsharing.org
is_a: T4FS:0000353 ! resource management
property_value: IAO:0000412 http://purl.obolibrary.org/obo/t4fs.owl

[Term]
id: T4FS:0000353
name: resource management
def: "Resource management is the efficient and effective development of an organization's resources when they are needed. Such resources may include the financial resources, inventory, human skills, production resources, or information technology (IT) and natural resources." []
is_a: T4FS:0000012 ! data stewardship activity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/t4fs.owl

[Term]
id: UBERON:0000000
name: processual entity
def: "An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity." []
is_a: GO:0008150 ! biological_process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0000061
name: anatomical structure
def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." []
is_a: UBERON:0000465 ! material anatomical entity
property_value: IAO:0000118 "biological structure" xsd:string
property_value: IAO:0000118 "connected biological structure" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0000062
name: organ
def: "Anatomical structure that performs a specific function or group of functions [WP]." []
subset: https://www.fairsharing.org
is_a: UBERON:0010000 ! multicellular anatomical structure
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0000104
name: life cycle
def: "An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism." []
subset: https://www.fairsharing.org
is_a: UBERON:0000000 ! processual entity
property_value: IAO:0000118 "entire life cycle" xsd:string
property_value: IAO:0000118 "entire lifespan" xsd:string
property_value: IAO:0000118 "life" xsd:string
property_value: IAO:0000118 "lifespan" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0000105
name: life cycle stage
def: "A spatiotemporal region encompassing some part of the life cycle of an organism." []
subset: https://www.fairsharing.org
is_a: UBERON:0000000 ! processual entity
property_value: IAO:0000118 "developmental stage" xsd:string
property_value: IAO:0000118 "stage" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0000178
name: blood
def: "A complex mixture of cells suspended in a liquid matrix that delivers nutrients to cells and removes wastes. (Source: BioGlossary, www.Biology-Text.com)[TAO]" []
subset: https://www.fairsharing.org
is_a: UBERON:0000465 ! material anatomical entity
property_value: IAO:0000118 "portion of blood" xsd:string
property_value: IAO:0000118 "vertebrate blood" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0000465
name: material anatomical entity
def: "Anatomical entity that has mass." []
is_a: UBERON:0001062 ! anatomical entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0000479
name: tissue
def: "Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation." []
subset: https://www.fairsharing.org
is_a: UBERON:0010000 ! multicellular anatomical structure
property_value: IAO:0000118 "portion of tissue" xsd:string
property_value: IAO:0000118 "simple tissue" xsd:string
property_value: IAO:0000118 "tissue portion" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0000948
name: heart
def: "A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ." []
subset: https://www.fairsharing.org
is_a: UBERON:0005177 ! trunk region element
property_value: IAO:0000118 "branchial heart" xsd:string
property_value: IAO:0000118 "chambered heart" xsd:string
property_value: IAO:0000118 "vertebrate heart" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0000955
name: brain
def: "Cavitated compound organ which is comprised of gray and white matter and surrounds the cerebral ventricular system.[TAO]" []
subset: https://www.fairsharing.org
is_a: UBERON:0000062 ! organ
is_a: UBERON:0004121 ! ectoderm-derived structure
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0001033
name: gustatory system
def: "The sensory system for the sense of taste." []
subset: https://www.fairsharing.org
is_a: UBERON:0000061 ! anatomical structure
property_value: IAO:0000118 "gustatory organ system" xsd:string
property_value: IAO:0000118 "taste system" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0001062
name: anatomical entity
def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." []
is_a: BFO:0000040 ! material entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0001474
name: bone element
def: "Also called osseous tissue, (Latin: os). Is a type of hard endoskeletal connective tissue found in many vertebrate animals. Bone is the main tissue of body organs that support body structures, protect internal organs, (in conjunction with muscles) facilitate movement; and are involved with cell formation, calcium metabolism, and mineral storage.[AAO]" []
subset: https://www.fairsharing.org
is_a: UBERON:0000062 ! organ
property_value: IAO:0000118 "bone organ" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0001911
name: mammary gland
def: "A specialized accessory gland of the skin of mammals that secretes milk. The gland is typically only developed in females, and regresses in males." []
subset: https://www.fairsharing.org
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0019319 ! exocrine gland of integumental system
property_value: IAO:0000118 "glandula mammaria" xsd:string
property_value: IAO:0000118 "lactiferous gland" xsd:string
property_value: IAO:0000118 "lobe of breast" xsd:string
property_value: IAO:0000118 "milk patch" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0002107
name: liver
def: "An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]." []
subset: https://www.fairsharing.org
is_a: UBERON:0002365 ! exocrine gland
is_a: UBERON:0005177 ! trunk region element
is_a: UBERON:0006925 ! digestive system gland
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0002365
name: exocrine gland
def: "A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas." []
is_a: UBERON:0002530 ! gland
property_value: IAO:0000118 "ducted gland" xsd:string
property_value: IAO:0000118 "glandula exocrina" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0002405
name: immune system
def: "Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies." []
subset: https://www.fairsharing.org
is_a: UBERON:0000465 ! material anatomical entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0002530
name: gland
def: "An organ that functions as a secretory or excretory organ." []
is_a: UBERON:0000062 ! organ
property_value: IAO:0000118 "glandular organ" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0004121
name: ectoderm-derived structure
def: "An anatomical structure that develops (entirely or partially) from the ectoderm." []
is_a: UBERON:0000061 ! anatomical structure
property_value: IAO:0000118 "ectodermal deriviative" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0004907
name: lower digestive tract
def: "The region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition]." []
subset: https://www.fairsharing.org
is_a: UBERON:0010000 ! multicellular anatomical structure
property_value: IAO:0000118 "lower gastrointestinal tract" xsd:string
property_value: IAO:0000118 "lower GI tract" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0005177
name: trunk region element
def: "An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions." []
is_a: UBERON:0000062 ! organ
property_value: IAO:0000118 "trunk organ" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0006925
name: digestive system gland
def: "Any gland that is part of the digestive system." []
is_a: UBERON:0002530 ! gland
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0010000
name: multicellular anatomical structure
def: "An anatomical structure that has more than one cell as a part." []
is_a: UBERON:0000061 ! anatomical structure
property_value: IAO:0000118 "multicellular structure" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UBERON:0019319
name: exocrine gland of integumental system
def: "An exocrine gland that is part of a integumental system." []
is_a: UBERON:0002365 ! exocrine gland
property_value: IAO:0000118 "integumental exocrine gland" xsd:string
property_value: IAO:0000118 "integumental system exocrine gland" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Term]
id: UO:0000000
name: unit
subset: https://www.fairsharing.org
is_a: IAO:0000027 ! data item
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uo.owl

[Term]
id: UnspecifiedCellType
name: unspecified cell type
is_a: CL:0000000 ! cell
property_value: IAO:0000412 http://purl.obolibrary.org/obo/clo.owl

[Term]
id: VO:0000001
name: vaccine
def: "Material entity that is manufactured to realize the vaccine function." []
subset: https://www.fairsharing.org
is_a: OBI:0000047 ! processed material
property_value: IAO:0000412 http://purl.obolibrary.org/obo/vo.owl

[Term]
id: biomodels:SBO_0000027
name: Michaelis constant
def: "Synonym: Michaelis-Menten constant " []
subset: https://www.fairsharing.org
is_a: biomodels:SBO_0000193 ! equilibrium or steady-state constant
property_value: IAO:0000412 http://purl.obolibrary.org/obo/sbo.owl

[Term]
id: biomodels:SBO_0000193
name: equilibrium or steady-state constant
def: "Constant with the dimension of a powered concentration. It is determined at half-saturation, half-activity etc. " []
is_a: biomodels:SBO_0000308 ! equilibrium or steady-state characteristic
property_value: IAO:0000412 http://purl.obolibrary.org/obo/sbo.owl

[Term]
id: biomodels:SBO_0000242
name: channel
def: "A component that allows another component to pass through itself, possibly connecting different compartments." []
subset: https://www.fairsharing.org
is_a: GO:0032991 ! protein-containing complex
property_value: IAO:0000412 http://purl.obolibrary.org/obo/sbo.owl

[Term]
id: biomodels:SBO_0000261
name: inhibitory constant
def: "Synonym: Ki " []
subset: https://www.fairsharing.org
is_a: biomodels:SBO_0000282 ! dissociation constant
property_value: IAO:0000412 http://purl.obolibrary.org/obo/sbo.owl

[Term]
id: biomodels:SBO_0000282
name: dissociation constant
def: "Synonym: Kd " []
is_a: biomodels:SBO_0000193 ! equilibrium or steady-state constant
property_value: IAO:0000412 http://purl.obolibrary.org/obo/sbo.owl

[Term]
id: biomodels:SBO_0000308
name: equilibrium or steady-state characteristic
def: "Quantitative parameter that characterises a biochemical equilibrium. " []
is_a: biomodels:SBO_0000545 ! systems description parameter
property_value: IAO:0000412 http://purl.obolibrary.org/obo/sbo.owl

[Term]
id: biomodels:SBO_0000414
name: cis
def: "Positional relationship between entities on the same strand (e.g. in DNA), or on the same side.\n" []
subset: https://www.fairsharing.org
is_a: IAO:0000030 ! information content entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/sbo.owl

[Term]
id: biomodels:SBO_0000493
name: functional domain
def: "A spatial region of an entity that confers a function" []
subset: https://www.fairsharing.org
is_a: edam:data_0883 ! Structure
property_value: IAO:0000412 http://purl.obolibrary.org/obo/sbo.owl

[Term]
id: biomodels:SBO_0000545
name: systems description parameter
def: "A value, numerical or symbolic, that defines certain characteristics of systems or system functions, or is necessary in their derivation." []
is_a: IAO:0000030 ! information content entity
property_value: IAO:0000412 http://purl.obolibrary.org/obo/sbo.owl

[Term]
id: c:16526
name: Bioenergy
def: "Bioenergy is renewable energy made available from materials derived from biological sources. [AL 6.3.18, source Wikipedia https://en.wikipedia.org/wiki/Bioenergy]." []
subset: https://www.fairsharing.org
is_a: PATO:0001021 ! energy
property_value: IAO:0000412 "https://agrovoc.fao.org/" xsd:string

[Term]
id: c:1971
name: Cropping systems
def: "The pattern of crops grown on a given piece of land, or order in which the crops are cultivated over a fixed period." []
subset: https://www.fairsharing.org
is_a: OBI:0000011 ! planned process
property_value: IAO:0000412 https://agrovoc.fao.org/

[Term]
id: c:33560
name: Sustainability
def: "The ability of a process or human activity to meet present needs but maintain natural resources and leave the environment in good order for future generations." []
comment: AL 6.3.18: Definition from AgroVoc
subset: https://www.fairsharing.org
is_a: PATO:0001018 ! physical quality
property_value: IAO:0000412 https://agrovoc.fao.org/

[Term]
id: c:36669
name: Agroecosystem
def: "A system where communities of plants, microbes and animals inhabiting farmed land, pastures, grasslands or rangelands, interact with each other and their physical environment." []
comment: AL 6.3.18: Definition from AgroVoc
subset: https://www.fairsharing.org
is_a: ENVO:01001110 ! ecosystem
property_value: IAO:0000412 https://agrovoc.fao.org/

[Term]
id: c:8678
name: Agricultural products
def: "Products in their original state or processed enough to be prepared for marketing." []
comment: AL 6.3.18: Definition from AgroVoc
subset: https://www.fairsharing.org
is_a: NCIT:C66892 ! Natural Product
property_value: IAO:0000412 https://agrovoc.fao.org/

[Term]
id: drao:DRAO_0000281
name: FAIR
def: "A resource is FAIR if it is compliant with the FAIR principles, a set of guidelines to make data Findable, Accessible, Interoperable, and Re-usable. These guidelines are useful for those wishing to enhance the reusability of their data holdings. Distinct from peer initiatives that focus on the human scholar, the FAIR Principles put specific emphasis on enhancing the ability of machines to automatically find and use the data, in addition to supporting its reuse by individuals." []
comment: AL 16.03.18: Definition modified from https://fairsharing.org/bsg-s001147.
subset: https://www.fairsharing.org
is_a: BFO:0000019 ! quality

[Term]
id: drao:DRAO_0000289
name: Biocuration
def: "Biocuration is the extraction of knowledge from unstructured biological and biomedical data into a standard, structured, computable form." []
comment: Adapted by PMQ 2018.09.10 and International Society for Biocuration. DOI: 10.1371/journal.pbio.2002846
subset: https://www.fairsharing.org
is_a: OBI:0302914 ! digital curation

[Term]
id: drao:DRAO_0000322
name: Approved drug
def: "An approved drug is a preparation that has been validated for a therapeutic use by a ruling authority of a government." []
comment: Wikipedia https://en.wikipedia.org/wiki/Approved_drug, accessed 20.5.20
subset: https://www.fairsharing.org
is_a: DRON:00000001 ! clinical drug role

[Term]
id: edam:data_0846
name: Chemical formula
def: "A specification of a chemical structure." []
subset: https://www.fairsharing.org
is_a: edam:data_2050 ! Molecular property (general)
property_value: IAO:0000118 "Chemical structure specification" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_0880
name: RNA secondary structure
def: "An informative report of secondary structure (predicted or real) of an RNA molecule." []
subset: https://www.fairsharing.org
is_a: edam:data_0883 ! Structure
property_value: IAO:0000118 "Secondary structure (RNA)" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_0883
name: Structure
def: "3D coordinate and associated data for a macromolecular tertiary (3D) structure or part of a structure." []
subset: https://www.fairsharing.org
is_a: PATO:0000141 ! structure
property_value: IAO:0000118 "Coordinate model" xsd:string
property_value: IAO:0000118 "Structure data" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_0912
name: Nucleic acid property
def: "A report of primarily non-positional data describing intrinsic physical, chemical or other properties of a nucleic acid molecule." []
subset: https://www.fairsharing.org
is_a: edam:data_2087 ! Molecular property
property_value: IAO:0000118 "GC-content" xsd:string
property_value: IAO:0000118 "Nucleic acid physicochemical property" xsd:string
property_value: IAO:0000118 "Nucleic acid property (structural)" xsd:string
property_value: IAO:0000118 "Nucleic acid structural property" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_0916
name: Gene report
def: "A report on predicted or actual gene structure, regions which make an RNA product and features such as promoters, coding regions, splice sites etc." []
subset: https://www.fairsharing.org
is_a: IAO:0000088 ! report
property_value: IAO:0000118 "Gene and transcript structure (report)" xsd:string
property_value: IAO:0000118 "Gene annotation" xsd:string
property_value: IAO:0000118 "Gene features report" xsd:string
property_value: IAO:0000118 "Gene function (report)" xsd:string
property_value: IAO:0000118 "Gene structure (repot)" xsd:string
property_value: IAO:0000118 "Nucleic acid features (gene and transcript structure)" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_0939
name: CD spectra
def: "Protein secondary structure from protein coordinate or circular dichroism (CD) spectroscopic data." []
subset: https://www.fairsharing.org
is_a: CHMO:0000800 ! spectrum
property_value: IAO:0000118 "CD spectrum" xsd:string
property_value: IAO:0000118 "Protein circular dichroism (CD) spectroscopic data" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_0942
name: 2D PAGE image
def: "Two-dimensional gel electrophoresis image." []
subset: https://www.fairsharing.org
is_a: IAO:0000101 ! image
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_0943
name: Mass spectrum
def: "Spectra from mass spectrometry." []
subset: https://www.fairsharing.org
is_a: CHMO:0000800 ! spectrum
property_value: IAO:0000118 "Mass spectrometry spectra" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_0945
name: Peptide identification
def: "Protein or peptide identifications with evidence supporting the identifications, for example from comparing a peptide mass fingerprint (from mass spectrometry) to a sequence database, or the set of typical spectra one obtains when running a protein through a mass spectrometer." []
subset: https://www.fairsharing.org
is_a: edam:data_2979 ! Peptide property
property_value: IAO:0000118 "'Protein identification'" xsd:string
property_value: IAO:0000118 "Peptide spectrum match" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_0976
name: Identifier (by type of entity)
def: "An identifier that identifies a particular type of data." []
is_a: IAO:0020000 ! identifier
property_value: IAO:0000118 "Identifier (typed)" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_0982
name: Molecule identifier
def: "Name or other identifier of a molecule." []
is_a: edam:data_0976 ! Identifier (by type of entity)
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_0984
name: Molecule name
def: "Name of a specific molecule." []
is_a: edam:data_0982 ! Molecule identifier
is_a: edam:data_2099 ! Name
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_0989
name: Protein identifier
def: "Identifier of a protein." []
is_a: edam:data_0982 ! Molecule identifier
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_0990
name: Compound name
def: "Unique name of a chemical compound." []
is_a: edam:data_0984 ! Molecule name
is_a: edam:data_1086 ! Compound identifier
property_value: IAO:0000118 "Chemical name" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_0993
name: Drug identifier
def: "Identifier of a drug." []
is_a: edam:data_1086 ! Compound identifier
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1009
name: Protein name
def: "Name of a protein." []
subset: https://www.fairsharing.org
is_a: edam:data_0984 ! Molecule name
is_a: edam:data_0989 ! Protein identifier
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1011
name: EC number
def: "An Enzyme Commission (EC) number of an enzyme." []
subset: https://www.fairsharing.org
is_a: edam:data_2091 ! Accession
is_a: edam:data_2321 ! Enzyme ID
property_value: drao:DRAO_0000001 "Enzyme Commission number" xsd:string
property_value: IAO:0000118 "EC" xsd:string
property_value: IAO:0000118 "EC code" xsd:string
property_value: IAO:0000118 "Enzyme Commission number" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1016
name: Sequence position
def: "A position of one or more points (base or residue) in a sequence, or part of such a specification." []
subset: https://www.fairsharing.org
is_a: SO:0000400 ! sequence_attribute
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1086
name: Compound identifier
def: "Identifier of an entry from a database of chemicals." []
is_a: edam:data_0982 ! Molecule identifier
property_value: IAO:0000118 "Chemical compound identifier" xsd:string
property_value: IAO:0000118 "Compound ID" xsd:string
property_value: IAO:0000118 "Small molecule identifier" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1235
name: Sequence cluster
def: "A set of sequences that have been clustered or otherwise classified as belonging to a group including (typically) sequence cluster information." []
subset: https://www.fairsharing.org
is_a: SO:0001260 ! sequence_collection
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1238
name: Proteolytic digest
def: "A protein sequence cleaved into peptide fragments (by enzymatic or chemical cleavage) with fragment masses." []
subset: https://www.fairsharing.org
is_a: SO:0001260 ! sequence_collection
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1240
name: PCR primers
def: "Oligonucleotide primer(s) for PCR and DNA amplification, for example a minimal primer set." []
subset: https://www.fairsharing.org
is_a: SO:0001260 ! sequence_collection
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1249
name: Sequence length
def: "The size (length) of a sequence, subsequence or region in a sequence, or range(s) of lengths." []
subset: https://www.fairsharing.org
is_a: SO:0000400 ! sequence_attribute
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1274
name: Map
def: "A map of (typically one) DNA sequence annotated with positional or non-positional features." []
is_a: IAO:0000027 ! data item
property_value: IAO:0000118 "DNA map" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1278
name: Genetic map
def: "A map showing the relative positions of genetic markers in a nucleic acid sequence, based on estimation of non-physical distance such as recombination frequencies." []
subset: https://www.fairsharing.org
is_a: edam:data_1274 ! Map
property_value: IAO:0000118 "Linkage map" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1280
name: Physical map
def: "A map of DNA (linear or circular) annotated with physical features or landmarks such as restriction sites, cloned DNA fragments, genes or genetic markers, along with the physical distances between them." []
subset: https://www.fairsharing.org
is_a: edam:data_1274 ! Map
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1283
name: Cytogenetic map
def: "A map showing banding patterns derived from direct observation of a stained chromosome." []
subset: https://www.fairsharing.org
is_a: edam:data_1280 ! Physical map
property_value: IAO:0000118 "Chromosome map" xsd:string
property_value: IAO:0000118 "Cytogenic map" xsd:string
property_value: IAO:0000118 "Cytologic map" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1288
name: Genome map
def: "Sequence map of a whole genome." []
subset: https://www.fairsharing.org
is_a: edam:data_1280 ! Physical map
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1383
name: Nucleic acid sequence alignment
def: "Alignment of multiple nucleotide sequences." []
subset: https://www.fairsharing.org
is_a: OBI:0002567 ! sequence alignment
property_value: IAO:0000118 "DNA sequence alignment" xsd:string
property_value: IAO:0000118 "RNA sequence alignment" xsd:string
property_value: IAO:0000118 "Sequence alignment (nucleic acid)" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1413
name: Sequence similarity
def: "Sequence similarity is the similarity (expressed as a percentage) of two molecular sequences calculated from their alignment, a scoring matrix for scoring characters substitutions and penalties for gap insertion and extension." []
subset: https://www.fairsharing.org
is_a: IAO:0000027 ! data item
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1460
name: Protein structure
def: "3D coordinate and associated data for a protein tertiary (3D) structure, or part of a structure, possibly in complex with other molecules." []
subset: https://www.fairsharing.org
is_a: edam:data_0883 ! Structure
property_value: IAO:0000118 "Protein structures" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1468
name: Protein domain
def: "3D coordinate and associated data for the tertiary (3D) structure of a protein domain." []
subset: https://www.fairsharing.org
is_a: edam:data_1460 ! Protein structure
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1479
name: Structure alignment (pair)
def: "Alignment (superimposition) of exactly two molecular tertiary (3D) structures." []
subset: https://www.fairsharing.org
is_a: OBI:0002567 ! sequence alignment
property_value: IAO:0000118 "Pair structure alignment" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1597
name: Codon usage table
def: "Table of codon usage data calculated from one or more nucleic acid sequences." []
subset: https://www.fairsharing.org
is_a: IAO:0000027 ! data item
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1696
name: Drug report
def: "A human-readable collection of information about a specific drug." []
subset: https://www.fairsharing.org
is_a: IAO:0000088 ! report
property_value: IAO:0000118 "Drug annotation" xsd:string
property_value: IAO:0000118 "Drug structure relationship map" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1712
name: Chemical structure image
def: "An image of the structure of a small chemical compound." []
subset: https://www.fairsharing.org
is_a: IAO:0000101 ! image
property_value: IAO:0000118 "Chemical structure sketch" xsd:string
property_value: IAO:0000118 "Small molecule sketch" xsd:string
property_value: IAO:0000118 "Small molecule structure image" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1743
name: Atomic coordinate
def: "Cartesian coordinate of an atom (in a molecular structure)." []
subset: https://www.fairsharing.org
is_a: edam:data_2087 ! Molecular property
property_value: IAO:0000118 "Cartesian coordinate" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_1872
name: Taxonomic classification
def: "The full name for a group of organisms, reflecting their biological classification and (usually) conforming to a standard nomenclature." []
subset: https://www.fairsharing.org
is_a: edam:data_2909 ! Organism name
property_value: IAO:0000118 "Taxonomic information" xsd:string
property_value: IAO:0000118 "Taxonomic name" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_2042
name: Evidence
def: "Typically a human-readable summary of body of facts or information indicating why a statement is true or valid. This may include a computational prediction, laboratory experiment, literature reference etc." []
subset: https://www.fairsharing.org
is_a: IAO:0000030 ! information content entity
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_2050
name: Molecular property (general)
def: "General data for a molecule." []
is_a: edam:data_2087 ! Molecular property
property_value: IAO:0000118 "General molecular property" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_2087
name: Molecular property
def: "A report on the physical (e.g. structural) or chemical properties of molecules, or parts of a molecule." []
is_a: IAO:0000027 ! data item
property_value: IAO:0000118 "Physicochemical property" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_2091
name: Accession
def: "A persistent (stable) and unique identifier, typically identifying an object (entry) from a database." []
is_a: IAO:0020000 ! identifier
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_2099
name: Name
def: "A name of a thing, which need not necessarily uniquely identify it." []
is_a: IAO:0020000 ! identifier
property_value: IAO:0000118 "Symbolic name" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_2140
name: Concentration
def: "The concentration of a chemical compound." []
subset: https://www.fairsharing.org
is_a: edam:data_2050 ! Molecular property (general)
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_2299
name: Gene name
def: "The name of a gene, (typically) assigned by a person and/or according to a naming scheme. It may contain white space characters and is typically more intuitive and readable than a gene symbol. It (typically) may be used to identify similar genes in different species and to derive a gene symbol." []
subset: https://www.fairsharing.org
is_a: edam:data_0976 ! Identifier (by type of entity)
is_a: edam:data_2099 ! Name
property_value: IAO:0000118 "Allele name" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_2321
name: Enzyme ID
def: "A unique, persistent identifier of an enzyme." []
is_a: edam:data_2907 ! Protein accession
property_value: IAO:0000118 "Enzyme accession" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_2337
name: Resource metadata
def: "Data concerning or describing some core computational resource, as distinct from primary data. This includes metadata on the origin, source, history, ownership or location of some thing." []
subset: https://www.fairsharing.org
is_a: IAO:0000088 ! report
property_value: IAO:0000118 "Provenance metadata" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_2603
name: Expression data
def: "Image, hybridisation or some other data arising from a study of feature/molecule expression, typically profiling or quantification." []
subset: https://www.fairsharing.org
is_a: CHMO:0000793 ! assay output
property_value: IAO:0000118 "Gene expression data" xsd:string
property_value: IAO:0000118 "Gene product profile" xsd:string
property_value: IAO:0000118 "Gene product quantification data" xsd:string
property_value: IAO:0000118 "Gene transcription profile" xsd:string
property_value: IAO:0000118 "Gene transcription quantification data" xsd:string
property_value: IAO:0000118 "Metabolite expression data" xsd:string
property_value: IAO:0000118 "Microarray data" xsd:string
property_value: IAO:0000118 "mRNA profile" xsd:string
property_value: IAO:0000118 "mRNA quantification data" xsd:string
property_value: IAO:0000118 "Non-coding RNA profile" xsd:string
property_value: IAO:0000118 "Non-coding RNA quantification data" xsd:string
property_value: IAO:0000118 "Protein expression data" xsd:string
property_value: IAO:0000118 "RNA profile" xsd:string
property_value: IAO:0000118 "RNA quantification data" xsd:string
property_value: IAO:0000118 "RNA-seq data" xsd:string
property_value: IAO:0000118 "Transcriptome profile" xsd:string
property_value: IAO:0000118 "Transcriptome quantification data" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_2717
name: Oligonucleotide probe annotation
def: "General annotation on an oligonucleotide probe, or a set of probes." []
subset: https://www.fairsharing.org
is_a: edam:data_2603 ! Expression data
property_value: IAO:0000118 "Oligonucleotide probe sets annotation" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_2851
name: Drug structure
def: "3D coordinate and associated data for the (3D) structure of a drug." []
subset: https://www.fairsharing.org
is_a: edam:data_0883 ! Structure
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_2899
name: Drug name
def: "Common name of a drug." []
subset: https://www.fairsharing.org
is_a: edam:data_0990 ! Compound name
is_a: edam:data_0993 ! Drug identifier
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_2907
name: Protein accession
def: "Accession of a protein deposited in a database." []
is_a: edam:data_0989 ! Protein identifier
property_value: IAO:0000118 "Protein accessions" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_2909
name: Organism name
def: "The name of an organism (or group of organisms)." []
is_a: edam:data_0976 ! Identifier (by type of entity)
is_a: edam:data_2099 ! Name
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_2977
name: Nucleic acid sequence
def: "One or more nucleic acid sequences, possibly with associated annotation." []
subset: https://www.fairsharing.org
is_a: SO:0001411 ! biological_region
property_value: IAO:0000118 "DNA sequence" xsd:string
property_value: IAO:0000118 "Nucleic acid sequences" xsd:string
property_value: IAO:0000118 "Nucleotide sequence" xsd:string
property_value: IAO:0000118 "Nucleotide sequences" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_2978
name: Reaction data
def: "Data concerning a biochemical reaction, typically data and more general annotation on the kinetics of enzyme-catalysed reaction." []
subset: https://www.fairsharing.org
is_a: IAO:0000027 ! data item
property_value: IAO:0000118 "Enzyme kinetics annotation" xsd:string
property_value: IAO:0000118 "Reaction annotation" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_2979
name: Peptide property
def: "Data concerning small peptides." []
subset: https://www.fairsharing.org
is_a: edam:data_2087 ! Molecular property
property_value: IAO:0000118 "Peptide data" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_3103
name: ATC code
def: "Unique identifier of a drug conforming to the Anatomical Therapeutic Chemical (ATC) Classification System, a drug classification system controlled by the WHO Collaborating Centre for Drug Statistics Methodology (WHOCC)." []
subset: https://www.fairsharing.org
is_a: edam:data_0993 ! Drug identifier
is_a: edam:data_2091 ! Accession
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_3108
name: Experimental measurement
def: "Raw data such as measurements or other results from laboratory experiments, as generated from laboratory hardware." []
subset: https://www.fairsharing.org
is_a: efo:EFO_0001444 ! measurement
property_value: IAO:0000118 "Experimental measurement data" xsd:string
property_value: IAO:0000118 "Experimentally measured data" xsd:string
property_value: IAO:0000118 "Measured data" xsd:string
property_value: IAO:0000118 "Measurement" xsd:string
property_value: IAO:0000118 "Measurement data" xsd:string
property_value: IAO:0000118 "Measurement metadata" xsd:string
property_value: IAO:0000118 "Raw experimental data" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_3110
name: Raw microarray data
def: "Raw data (typically MIAME-compliant) for hybridisations from a microarray experiment." []
subset: https://www.fairsharing.org
is_a: edam:data_2603 ! Expression data
is_a: edam:data_3108 ! Experimental measurement
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_3113
name: Sample annotation
def: "Annotation on a biological sample, for example experimental factors and their values." []
subset: https://www.fairsharing.org
is_a: edam:data_2337 ! Resource metadata
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_3153
name: Protein image
def: "An image of a protein." []
subset: https://www.fairsharing.org
is_a: IAO:0000101 ! image
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_3494
name: DNA sequence
def: "A DNA sequence." []
subset: https://www.fairsharing.org
is_a: edam:data_2977 ! Nucleic acid sequence
property_value: IAO:0000118 "DNA sequences" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_3495
name: RNA sequence
def: "An RNA sequence." []
subset: https://www.fairsharing.org
is_a: edam:data_2977 ! Nucleic acid sequence
property_value: IAO:0000118 "RNA sequences" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_3720
name: Geographic location
def: "A report about localisation of the isolaton of biological material e.g. country or coordinates." []
subset: https://www.fairsharing.org
is_a: IAO:0000088 ! report
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:data_3754
name: GO-term enrichment data
def: "A ranked list of Gene Ontology concepts, each associated with a p-value, concerning or derived from the analysis of e.g. a set of genes or proteins." []
subset: https://www.fairsharing.org
is_a: IAO:0000027 ! data item
property_value: IAO:0000118 "Gene ontology concept over-representation report" xsd:string
property_value: IAO:0000118 "Gene ontology enrichment report" xsd:string
property_value: IAO:0000118 "Gene ontology term enrichment report" xsd:string
property_value: IAO:0000118 "GO-term enrichment report" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_0004
name: Operation
def: "A function that processes a set of inputs and results in a set of outputs, or associates arguments (inputs) with values (outputs)." []
is_a: OBI:0200000 ! data transformation
property_value: IAO:0000118 "Computational method" xsd:string
property_value: IAO:0000118 "Computational operation" xsd:string
property_value: IAO:0000118 "Computational procedure" xsd:string
property_value: IAO:0000118 "Computational subroutine" xsd:string
property_value: IAO:0000118 "Function (programming)" xsd:string
property_value: IAO:0000118 "Lambda abstraction" xsd:string
property_value: IAO:0000118 "Mathematical function" xsd:string
property_value: IAO:0000118 "Mathematical operation" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_0226
name: Annotation
def: "Annotate an entity (typically a biological or biomedical database entity) with terms from a controlled vocabulary." []
subset: https://www.fairsharing.org
is_a: edam:operation_0004 ! Operation
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_0267
name: Protein secondary structure prediction
def: "Predict secondary structure of protein sequences." []
is_a: edam:operation_3092 ! Protein feature detection
property_value: IAO:0000118 "Secondary structure prediction (protein)" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_0269
name: Transmembrane protein prediction
def: "Predict and/or classify transmembrane proteins or transmembrane (helical) domains or regions in protein sequences." []
subset: https://www.fairsharing.org
is_a: edam:operation_0267 ! Protein secondary structure prediction
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_0294
name: Structure-based sequence alignment
def: "Align molecular sequences using sequence and structural information." []
subset: https://www.fairsharing.org
is_a: OBI:0002567 ! sequence alignment
property_value: IAO:0000118 "Sequence alignment (structure-based)" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_0306
name: Text mining
def: "Process and analyse text (typically scientific literature) to extract information from it." []
subset: https://www.fairsharing.org
is_a: edam:operation_2423 ! Prediction and recognition
is_a: edam:operation_2945 ! Data analysis
property_value: IAO:0000118 "Literature mining" xsd:string
property_value: IAO:0000118 "Text analytics" xsd:string
property_value: IAO:0000118 "Text data mining" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_0314
name: Gene expression profiling
def: "The measurement of the activity (expression) of multiple genes in a cell, tissue, sample etc., in order to get an impression of biological function." []
is_a: edam:operation_2945 ! Data analysis
property_value: IAO:0000118 "Feature expression analysis" xsd:string
property_value: IAO:0000118 "Functional profiling" xsd:string
property_value: IAO:0000118 "Gene expression profile construction" xsd:string
property_value: IAO:0000118 "Gene expression profile generation" xsd:string
property_value: IAO:0000118 "Gene expression quantification" xsd:string
property_value: IAO:0000118 "Gene transcription profiling" xsd:string
property_value: IAO:0000118 "mRNA profiling" xsd:string
property_value: IAO:0000118 "Non-coding RNA profiling" xsd:string
property_value: IAO:0000118 "Protein profiling" xsd:string
property_value: IAO:0000118 "RNA profiling" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_0361
name: Sequence annotation
def: "Annotate a molecular sequence record with terms from a controlled vocabulary." []
subset: https://www.fairsharing.org
is_a: edam:operation_0226 ! Annotation
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_0362
name: Genome annotation
def: "Annotate a genome sequence with terms from a controlled vocabulary." []
subset: https://www.fairsharing.org
is_a: edam:operation_0361 ! Sequence annotation
is_a: edam:operation_3918 ! Genome analysis
property_value: IAO:0000118 "Functional genome annotation" xsd:string
property_value: IAO:0000118 "Metagenome annotation" xsd:string
property_value: IAO:0000118 "Structural genome annotation" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_0417
name: Post-translational modification site prediction
def: "Predict post-translation modification sites in protein sequences." []
subset: https://www.fairsharing.org
is_a: edam:operation_3092 ! Protein feature detection
property_value: IAO:0000118 "Acetylation prediction" xsd:string
property_value: IAO:0000118 "Acetylation site prediction" xsd:string
property_value: IAO:0000118 "Dephosphorylation prediction" xsd:string
property_value: IAO:0000118 "Dephosphorylation site prediction" xsd:string
property_value: IAO:0000118 "Glycosylation prediction" xsd:string
property_value: IAO:0000118 "Glycosylation site prediction" xsd:string
property_value: IAO:0000118 "GPI anchor prediction" xsd:string
property_value: IAO:0000118 "GPI anchor site prediction" xsd:string
property_value: IAO:0000118 "GPI modification prediction" xsd:string
property_value: IAO:0000118 "GPI modification site prediction" xsd:string
property_value: IAO:0000118 "Hydroxylation prediction" xsd:string
property_value: IAO:0000118 "Hydroxylation site prediction" xsd:string
property_value: IAO:0000118 "Methylation prediction" xsd:string
property_value: IAO:0000118 "Methylation site prediction" xsd:string
property_value: IAO:0000118 "N-myristoylation prediction" xsd:string
property_value: IAO:0000118 "N-myristoylation site prediction" xsd:string
property_value: IAO:0000118 "N-terminal acetylation prediction" xsd:string
property_value: IAO:0000118 "N-terminal acetylation site prediction" xsd:string
property_value: IAO:0000118 "N-terminal myristoylation prediction" xsd:string
property_value: IAO:0000118 "N-terminal myristoylation site prediction" xsd:string
property_value: IAO:0000118 "Palmitoylation prediction" xsd:string
property_value: IAO:0000118 "Palmitoylation site prediction" xsd:string
property_value: IAO:0000118 "Phosphoglycerylation prediction" xsd:string
property_value: IAO:0000118 "Phosphoglycerylation site prediction" xsd:string
property_value: IAO:0000118 "Phosphorylation prediction" xsd:string
property_value: IAO:0000118 "Phosphorylation site prediction" xsd:string
property_value: IAO:0000118 "Phosphosite localization" xsd:string
property_value: IAO:0000118 "Post-translation modification site prediction" xsd:string
property_value: IAO:0000118 "Post-translational modification analysis" xsd:string
property_value: IAO:0000118 "Prenylation prediction" xsd:string
property_value: IAO:0000118 "Prenylation site prediction" xsd:string
property_value: IAO:0000118 "Protein post-translation modification site prediction" xsd:string
property_value: IAO:0000118 "PTM analysis" xsd:string
property_value: IAO:0000118 "PTM prediction" xsd:string
property_value: IAO:0000118 "PTM site analysis" xsd:string
property_value: IAO:0000118 "PTM site prediction" xsd:string
property_value: IAO:0000118 "Pupylation prediction" xsd:string
property_value: IAO:0000118 "Pupylation site prediction" xsd:string
property_value: IAO:0000118 "S-nitrosylation prediction" xsd:string
property_value: IAO:0000118 "S-nitrosylation site prediction" xsd:string
property_value: IAO:0000118 "S-sulfenylation prediction" xsd:string
property_value: IAO:0000118 "S-sulfenylation site prediction" xsd:string
property_value: IAO:0000118 "Succinylation prediction" xsd:string
property_value: IAO:0000118 "Succinylation site prediction" xsd:string
property_value: IAO:0000118 "Sulfation prediction" xsd:string
property_value: IAO:0000118 "Sulfation site prediction" xsd:string
property_value: IAO:0000118 "Sumoylation prediction" xsd:string
property_value: IAO:0000118 "Sumoylation site prediction" xsd:string
property_value: IAO:0000118 "Tyrosine nitration prediction" xsd:string
property_value: IAO:0000118 "Tyrosine nitration site prediction" xsd:string
property_value: IAO:0000118 "Ubiquitination prediction" xsd:string
property_value: IAO:0000118 "Ubiquitination site prediction" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_0422
name: Protein cleavage site prediction
def: "Detect or predict cleavage sites (enzymatic or chemical) in protein sequences." []
subset: https://www.fairsharing.org
is_a: edam:operation_3092 ! Protein feature detection
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_0435
name: Operon prediction
def: "Find operons (operators, promoters and genes) in bacteria genes." []
subset: https://www.fairsharing.org
is_a: edam:operation_2454 ! Gene prediction
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_0445
name: Transcription factor binding site prediction
def: "Identify or predict transcription factor binding sites in DNA sequences." []
subset: https://www.fairsharing.org
is_a: edam:operation_2454 ! Gene prediction
property_value: IAO:0000118 "TF binding site prediction" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_0450
name: Chimera detection
def: "Detects chimeric sequences (chimeras) from a sequence alignment." []
subset: https://www.fairsharing.org
is_a: edam:operation_2478 ! Nucleic acid sequence analysis
property_value: IAO:0000118 "Chimeric sequence detection" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_0488
name: Linkage disequilibrium calculation
def: "Calculate linkage disequilibrium; the non-random association of alleles or polymorphisms at two or more loci (not necessarily on the same chromosome)." []
subset: https://www.fairsharing.org
is_a: edam:operation_2478 ! Nucleic acid sequence analysis
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_0492
name: Multiple sequence alignment
def: "Align more than two molecular sequences." []
subset: https://www.fairsharing.org
is_a: OBI:0002567 ! sequence alignment
property_value: IAO:0000118 "Multiple alignment" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_0525
name: Genome assembly
def: "The process of assembling many short DNA sequences together such that they represent the original chromosomes from which the DNA originated." []
subset: https://www.fairsharing.org
is_a: edam:operation_3918 ! Genome analysis
property_value: IAO:0000118 "Breakend assembly" xsd:string
property_value: IAO:0000118 "Genomic assembly" xsd:string
property_value: IAO:0000118 "Sequence assembly (genome assembly)" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_0564
name: Sequence visualisation
def: "Visualise, format or render a molecular sequence or sequences such as a sequence alignment, possibly with sequence features or properties shown." []
is_a: edam:operation_2403 ! Sequence analysis
property_value: IAO:0000118 "Sequence alignment visualisation" xsd:string
property_value: IAO:0000118 "Sequence rendering" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_1777
name: Protein function prediction
def: "Predict the biological or biochemical role of a protein, or other aspects of a protein function." []
is_a: edam:operation_2423 ! Prediction and recognition
is_a: edam:operation_2945 ! Data analysis
property_value: IAO:0000118 "Protein function analysis" xsd:string
property_value: IAO:0000118 "Protein functional analysis" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_2403
name: Sequence analysis
def: "Analyse one or more known molecular sequences." []
is_a: edam:operation_2945 ! Data analysis
property_value: IAO:0000118 "Sequence analysis (general)" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_2422
name: Data retrieval
def: "Retrieve an entry (or part of an entry) from a data resource that matches a supplied query. This might include some primary data and annotation. The query is a data identifier or other indexed term. For example, retrieve a sequence record with the specified accession number, or matching supplied keywords." []
subset: https://www.fairsharing.org
is_a: edam:operation_0306 ! Text mining
property_value: IAO:0000118 "Data extraction" xsd:string
property_value: IAO:0000118 "Data retrieval (metadata)" xsd:string
property_value: IAO:0000118 "Metadata retrieval" xsd:string
property_value: IAO:0000118 "Retrieval" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_2423
name: Prediction and recognition
def: "Predict, recognise, detect or identify some properties of a biomolecule." []
subset: https://www.fairsharing.org
is_a: edam:operation_0004 ! Operation
property_value: IAO:0000118 "Detection" xsd:string
property_value: IAO:0000118 "Prediction" xsd:string
property_value: IAO:0000118 "Recognition" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_2428
name: Validation
def: "Validate some data." []
subset: https://www.fairsharing.org
is_a: edam:operation_0004 ! Operation
property_value: IAO:0000118 "Quality control" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_2454
name: Gene prediction
def: "Detect, predict and identify genes or components of genes in DNA sequences, including promoters, coding regions, splice sites, etc." []
subset: https://www.fairsharing.org
is_a: edam:operation_2478 ! Nucleic acid sequence analysis
property_value: IAO:0000118 "Gene calling" xsd:string
property_value: IAO:0000118 "Gene finding" xsd:string
property_value: IAO:0000118 "Whole gene prediction" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_2478
name: Nucleic acid sequence analysis
def: "Analyse a nucleic acid sequence (using methods that are only applicable to nucleic acid sequences)." []
is_a: edam:operation_2403 ! Sequence analysis
property_value: IAO:0000118 "Nucleic acid sequence alignment analysis" xsd:string
property_value: IAO:0000118 "Sequence alignment analysis (nucleic acid)" xsd:string
property_value: IAO:0000118 "Sequence analysis (nucleic acid)" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_2479
name: Protein sequence analysis
def: "Analyse a protein sequence (using methods that are only applicable to protein sequences)." []
is_a: edam:operation_2403 ! Sequence analysis
property_value: IAO:0000118 "Protein sequence alignment analysis" xsd:string
property_value: IAO:0000118 "Sequence alignment analysis (protein)" xsd:string
property_value: IAO:0000118 "Sequence analysis (protein)" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_2492
name: Protein interaction prediction
def: "Predict the interactions of proteins with other proteins." []
is_a: edam:operation_1777 ! Protein function prediction
property_value: IAO:0000118 "Protein-protein binding prediction" xsd:string
property_value: IAO:0000118 "Protein-protein interaction detection" xsd:string
property_value: IAO:0000118 "Protein-protein interaction prediction" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_2575
name: Binding site prediction
def: "Identify or predict catalytic residues, active sites or other ligand-binding sites in protein sequences or structures." []
subset: https://www.fairsharing.org
is_a: edam:operation_1777 ! Protein function prediction
is_a: edam:operation_3092 ! Protein feature detection
property_value: IAO:0000118 "Protein binding site detection" xsd:string
property_value: IAO:0000118 "Protein binding site prediction" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_2945
name: Data analysis
def: "Apply analytical methods to existing data of a specific type." []
subset: https://www.fairsharing.org
is_a: edam:operation_0004 ! Operation
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_3092
name: Protein feature detection
def: "Predict, recognise and identify positional features in proteins from analysing protein sequences or structures." []
is_a: edam:operation_2423 ! Prediction and recognition
is_a: edam:operation_2479 ! Protein sequence analysis
property_value: IAO:0000118 "Protein feature prediction" xsd:string
property_value: IAO:0000118 "Protein feature recognition" xsd:string
property_value: IAO:0000118 "Protein secondary database search" xsd:string
property_value: IAO:0000118 "Protein site detection" xsd:string
property_value: IAO:0000118 "Protein site prediction" xsd:string
property_value: IAO:0000118 "Protein site recognition" xsd:string
property_value: IAO:0000118 "Sequence feature detection (protein)" xsd:string
property_value: IAO:0000118 "Sequence profile database search" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_3095
name: Nucleic acid design
def: "Design (or predict) nucleic acid sequences with specific chemical or physical properties." []
subset: https://www.fairsharing.org
is_a: edam:operation_2478 ! Nucleic acid sequence analysis
property_value: IAO:0000118 "Gene design" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_3182
name: Genome alignment
def: "Align two or more (tpyically huge) molecular sequences that represent genomes." []
subset: https://www.fairsharing.org
is_a: OBI:0002567 ! sequence alignment
property_value: IAO:0000118 "Genome alignment construction" xsd:string
property_value: IAO:0000118 "Whole genome alignment" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_3196
name: Genotyping
def: "Analyse DNA sequence data to identify differences between the genetic composition (genotype) of an individual compared to other individual's or a reference sequence." []
subset: https://www.fairsharing.org
is_a: edam:operation_2945 ! Data analysis
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_3208
name: Genome visualisation
def: "Visualise, format or render a nucleic acid sequence that is part of (and in context of) a complete genome sequence." []
subset: https://www.fairsharing.org
is_a: edam:operation_0564 ! Sequence visualisation
is_a: edam:operation_3918 ! Genome analysis
property_value: IAO:0000118 "Genome browser" xsd:string
property_value: IAO:0000118 "Genome browsing" xsd:string
property_value: IAO:0000118 "Genome rendering" xsd:string
property_value: IAO:0000118 "Genome viewing" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_3223
name: Differential gene expression profiling
def: "Identify from molecular sequence analysis (typically from analysis of microarray or RNA-seq data) genes whose expression levels are significantly different between two sample groups." []
subset: https://www.fairsharing.org
is_a: edam:operation_0314 ! Gene expression profiling
property_value: IAO:0000118 "Differential expression analysis" xsd:string
property_value: IAO:0000118 "Differential gene analysis" xsd:string
property_value: IAO:0000118 "Differential gene expression analysis" xsd:string
property_value: IAO:0000118 "Differentially expressed gene identification" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_3432
name: Clustering
def: "Group together some data entities on the basis of similarities such that entities in the same group (cluster) are more similar to each other than to those in other groups (clusters)." []
subset: https://www.fairsharing.org
is_a: edam:operation_0004 ! Operation
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_3672
name: Gene functional annotation
def: "Annotate one or more sequences with functional information, such as cellular processes or metaobolic pathways, by reference to a controlled vocabulary - invariably the Gene Ontology (GO)." []
subset: https://www.fairsharing.org
is_a: edam:operation_0361 ! Sequence annotation
property_value: IAO:0000118 "Sequence functional annotation" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_3741
name: Differential protein expression profiling
def: "The analysis, using proteomics techniques, to identify proteins whose encoding genes are differentially expressed under a given experimental setup." []
subset: https://www.fairsharing.org
is_a: edam:operation_0314 ! Gene expression profiling
property_value: IAO:0000118 "Differential protein expression analysis" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_3767
name: Protein identification
def: "Identification of protein, for example from one or more peptide identifications by tandem mass spectrometry." []
subset: https://www.fairsharing.org
is_a: edam:operation_2423 ! Prediction and recognition
is_a: edam:operation_2945 ! Data analysis
property_value: IAO:0000118 "Protein inference" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_3799
name: Quantification
def: "Counting and measuring experimentally determined observations into quantities." []
subset: https://www.fairsharing.org
is_a: edam:operation_0004 ! Operation
property_value: IAO:0000118 "Quantitation" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_3918
name: Genome analysis
def: "Study of genomic feature structure, variation, function and evolution at a genomic scale." []
is_a: edam:operation_2478 ! Nucleic acid sequence analysis
property_value: IAO:0000118 "Genomic analysis" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:operation_3927
name: Network analysis
def: "Generate, process or analyse a biological network." []
subset: https://www.fairsharing.org
is_a: edam:operation_2945 ! Data analysis
property_value: IAO:0000118 "Biological network analysis" xsd:string
property_value: IAO:0000118 "Biological network modelling" xsd:string
property_value: IAO:0000118 "Biological network prediction" xsd:string
property_value: IAO:0000118 "Network comparison" xsd:string
property_value: IAO:0000118 "Network modelling" xsd:string
property_value: IAO:0000118 "Network prediction" xsd:string
property_value: IAO:0000118 "Network simulation" xsd:string
property_value: IAO:0000118 "Network topology simulation" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:topic_0128
name: Protein interactions
def: "Protein-protein, protein-DNA/RNA and protein-ligand interactions, including analysis of known interactions and prediction of putative interactions." []
subset: https://www.fairsharing.org
is_a: MI:0000 ! molecular interaction
property_value: IAO:0000118 "Protein interaction map" xsd:string
property_value: IAO:0000118 "Protein interaction networks" xsd:string
property_value: IAO:0000118 "Protein interactome" xsd:string
property_value: IAO:0000118 "Protein-DNA interaction" xsd:string
property_value: IAO:0000118 "Protein-DNA interactions" xsd:string
property_value: IAO:0000118 "Protein-ligand interactions" xsd:string
property_value: IAO:0000118 "Protein-nucleic acid interactions" xsd:string
property_value: IAO:0000118 "Protein-protein interactions" xsd:string
property_value: IAO:0000118 "Protein-RNA interaction" xsd:string
property_value: IAO:0000118 "Protein-RNA interactions" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:topic_0157
name: Sequence composition, complexity and repeats
def: "The archival, processing and analysis of the basic character composition of molecular sequences, for example character or word frequency, ambiguity, complexity, particularly regions of low complexity, and repeats or the repetitive nature of molecular sequences." []
subset: https://www.fairsharing.org
is_a: SO:0000400 ! sequence_attribute
property_value: IAO:0000118 "Low complexity sequences" xsd:string
property_value: IAO:0000118 "Nucleic acid repeats" xsd:string
property_value: IAO:0000118 "Protein repeats" xsd:string
property_value: IAO:0000118 "Protein sequence repeats" xsd:string
property_value: IAO:0000118 "Repeat sequences" xsd:string
property_value: IAO:0000118 "Sequence complexity" xsd:string
property_value: IAO:0000118 "Sequence composition" xsd:string
property_value: IAO:0000118 "Sequence repeats" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:topic_0621
name: Model organisms
def: "A specific organism, or group of organisms, used to study a particular aspect of biology." []
subset: https://www.fairsharing.org
is_a: BFO:0000023 ! role
property_value: IAO:0000118 "Organisms" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:topic_1775
name: Function analysis
def: "The study of gene and protein function including the prediction of functional properties of a protein." []
subset: https://www.fairsharing.org
is_a: edam:operation_2945 ! Data analysis
property_value: IAO:0000118 "Functional analysis" xsd:string
property_value: IAO:0000118 "Protein function analysis" xsd:string
property_value: IAO:0000118 "Protein function prediction" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:topic_3077
name: Data acquisition
def: "The acquisition of data, typically measurements of physical systems using any type of sampling system, or by another other means." []
subset: https://www.fairsharing.org
is_a: OBI:0000011 ! planned process
property_value: IAO:0000118 "Data collecting" xsd:string
property_value: IAO:0000118 "Data collection" xsd:string
property_value: IAO:0000118 "Data gathering" xsd:string
property_value: IAO:0000118 "Experimental techniques" xsd:string
property_value: IAO:0000118 "Experiments" xsd:string
property_value: IAO:0000118 "Lab method" xsd:string
property_value: IAO:0000118 "Lab techniques" xsd:string
property_value: IAO:0000118 "Laboratory experiments" xsd:string
property_value: IAO:0000118 "Laboratory method" xsd:string
property_value: IAO:0000118 "Laboratory techniques" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:topic_3337
name: Biobank
def: "Repositories of biological samples, typically human, for basic biological and clinical research." []
subset: https://www.fairsharing.org
is_a: BFO:0000040 ! material entity
property_value: IAO:0000118 "biobanking" xsd:string
property_value: IAO:0000118 "Tissue collection" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:topic_3341
name: Clone library
def: "Collections of DNA, including both collections of cloned molecules, and populations of micro-organisms that store and propagate cloned DNA." []
subset: https://www.fairsharing.org
is_a: BFO:0000040 ! material entity
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:topic_3345
name: Data identity and mapping
def: "Topic concerning the identity of biological entities, or reports on such entities, and the mapping of entities and records in different databases." []
subset: https://www.fairsharing.org
is_a: T4FS:0000141 ! data management
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:topic_3382
name: Imaging
def: "The visual representation of an object." []
subset: https://www.fairsharing.org
is_a: edam:topic_3077 ! Data acquisition
property_value: IAO:0000118 "Diffraction experiment" xsd:string
property_value: IAO:0000118 "Microscopy" xsd:string
property_value: IAO:0000118 "Microscopy imaging" xsd:string
property_value: IAO:0000118 "Optical super resolution microscopy" xsd:string
property_value: IAO:0000118 "Photonic force microscopy" xsd:string
property_value: IAO:0000118 "Photonic microscopy" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:topic_3383
name: Bioimaging
def: "The use of imaging techniques to understand biology." []
subset: https://www.fairsharing.org
is_a: edam:topic_3382 ! Imaging
property_value: IAO:0000118 "Biological imaging" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:topic_3384
name: Medical imaging
def: "The use of imaging techniques for clinical purposes for medical research." []
subset: https://www.fairsharing.org
is_a: edam:topic_3382 ! Imaging
property_value: IAO:0000118 "Neuroimaging" xsd:string
property_value: IAO:0000118 "Nuclear medicine" xsd:string
property_value: IAO:0000118 "Radiology" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: edam:topic_3386
name: Laboratory animal science
def: "The use of animals and alternatives in experimental research." []
subset: https://www.fairsharing.org
is_a: OBI:0000011 ! planned process
property_value: IAO:0000118 "Animal experimentation" xsd:string
property_value: IAO:0000118 "Animal research" xsd:string
property_value: IAO:0000118 "Animal testing" xsd:string
property_value: IAO:0000118 "In vivo testing" xsd:string
property_value: IAO:0000412 edam:EDAM.owl

[Term]
id: efo:EFO_0000269
name: array design
def: "An instrument design which describes the design of the array." []
subset: https://www.fairsharing.org
is_a: IAO:0000030 ! information content entity
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0000319
name: cardiovascular disease
def: "A body system disease which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." []
subset: https://www.fairsharing.org
is_a: OGMS:0000031 ! disease
property_value: IAO:0000118 "[X]Cardiovascular disease, unspecified" xsd:string
property_value: IAO:0000118 "[X]Cardiovascular disease, unspecified (disorder)" xsd:string
property_value: IAO:0000118 "[X]Other forms of heart disease" xsd:string
property_value: IAO:0000118 "[X]Other forms of heart disease (disorder)" xsd:string
property_value: IAO:0000118 "[X]Other ill-defined heart diseases" xsd:string
property_value: IAO:0000118 "[X]Other ill-defined heart diseases (disorder)" xsd:string
property_value: IAO:0000118 "[X]Other specified diseases of pericardium" xsd:string
property_value: IAO:0000118 "[X]Other specified diseases of pericardium (disorder)" xsd:string
property_value: IAO:0000118 "ASCVD" xsd:string
property_value: IAO:0000118 "CARDIOVASC DIS" xsd:string
property_value: IAO:0000118 "cardiovascular disease" xsd:string
property_value: IAO:0000118 "Cardiovascular Disease (CVD)" xsd:string
property_value: IAO:0000118 "cardiovascular disease (CVD)" xsd:string
property_value: IAO:0000118 "Cardiovascular disease, NOS" xsd:string
property_value: IAO:0000118 "Cardiovascular disease, unspecified" xsd:string
property_value: IAO:0000118 "Cardiovascular Diseases" xsd:string
property_value: IAO:0000118 "Cardiovascular Disorder" xsd:string
property_value: IAO:0000118 "cardiovascular disorder" xsd:string
property_value: IAO:0000118 "Cardiovascular disorder, NOS" xsd:string
property_value: IAO:0000118 "Cardiovascular Disorders" xsd:string
property_value: IAO:0000118 "Cardiovascular system disease" xsd:string
property_value: IAO:0000118 "cardiovascular system disease" xsd:string
property_value: IAO:0000118 "cardiovascular system disease or disorder" xsd:string
property_value: IAO:0000118 "Certain sequelae of myocardial infarction, not elsewhere classified" xsd:string
property_value: IAO:0000118 "CIRCULATORY DISEASE NOS" xsd:string
property_value: IAO:0000118 "circulatory system disease" xsd:string
property_value: IAO:0000118 "Circulatory system disease NOS" xsd:string
property_value: IAO:0000118 "Circulatory system disease NOS (disorder)" xsd:string
property_value: IAO:0000118 "CVD" xsd:string
property_value: IAO:0000118 "CVD, NOS" xsd:string
property_value: IAO:0000118 "CVS disease" xsd:string
property_value: IAO:0000118 "Disease affecting entire cardiovascular system" xsd:string
property_value: IAO:0000118 "Disease affecting entire cardiovascular system (disorder)" xsd:string
property_value: IAO:0000118 "Disease of cardiovascular system" xsd:string
property_value: IAO:0000118 "disease of cardiovascular system" xsd:string
property_value: IAO:0000118 "Disease of cardiovascular system (disorder)" xsd:string
property_value: IAO:0000118 "Disease of cardiovascular system, NOS" xsd:string
property_value: IAO:0000118 "disease of subdivision of hemolymphoid system" xsd:string
property_value: IAO:0000118 "disease or disorder of cardiovascular system" xsd:string
property_value: IAO:0000118 "Disease, Cardiovascular" xsd:string
property_value: IAO:0000118 "DISEASES OF THE CIRCULATORY SYSTEM" xsd:string
property_value: IAO:0000118 "Diseases, Cardiovascular" xsd:string
property_value: IAO:0000118 "Disorder of cardiovascular system" xsd:string
property_value: IAO:0000118 "disorder of cardiovascular system" xsd:string
property_value: IAO:0000118 "Disorder of cardiovascular system (disorder)" xsd:string
property_value: IAO:0000118 "Disorder of circulatory system" xsd:string
property_value: IAO:0000118 "Disorder of circulatory system, NOS" xsd:string
property_value: IAO:0000118 "Disorder of the circulatory system" xsd:string
property_value: IAO:0000118 "Ill-defined descriptions and complications of heart disease" xsd:string
property_value: IAO:0000118 "ILL-DEFINED HRT DIS NEC" xsd:string
property_value: IAO:0000118 "Other diseases of endocardium" xsd:string
property_value: IAO:0000118 "Other diseases of endocardium (disorder)" xsd:string
property_value: IAO:0000118 "Other diseases of pericardium" xsd:string
property_value: IAO:0000118 "Other diseases of pericardium (disorder)" xsd:string
property_value: IAO:0000118 "Other disorders of papillary muscle" xsd:string
property_value: IAO:0000118 "Other forms of heart disease" xsd:string
property_value: IAO:0000118 "Other forms of heart disease (disorder)" xsd:string
property_value: IAO:0000118 "Other heart disease" xsd:string
property_value: IAO:0000118 "Other heart disease (disorder)" xsd:string
property_value: IAO:0000118 "Other heart disease NOS" xsd:string
property_value: IAO:0000118 "Other heart disease NOS (disorder)" xsd:string
property_value: IAO:0000118 "Other ill-defined heart disease" xsd:string
property_value: IAO:0000118 "Other ill-defined heart disease (disorder)" xsd:string
property_value: IAO:0000118 "Other ill-defined heart disease NOS" xsd:string
property_value: IAO:0000118 "Other ill-defined heart disease NOS (disorder)" xsd:string
property_value: IAO:0000118 "Other ill-defined heart diseases" xsd:string
property_value: IAO:0000118 "Other pericardial disease NOS" xsd:string
property_value: IAO:0000118 "Other pericardial disease NOS (disorder)" xsd:string
property_value: IAO:0000118 "OTHER SEQUELAE OF MI NEC" xsd:string
property_value: IAO:0000118 "Other sequelae of myocardial infarction, not elsewhere classified" xsd:string
property_value: IAO:0000118 "Other specified diseases of pericardium" xsd:string
property_value: IAO:0000118 "Other specified pericardial disease NOS" xsd:string
property_value: IAO:0000118 "Other specified pericardial disease NOS (disorder)" xsd:string
property_value: IAO:0000118 "PAPILLARY MUSCLE DIS NEC" xsd:string
property_value: IAO:0000118 "PERICARDIAL DISEASE NEC" xsd:string
property_value: IAO:0000118 "Unspecified circulatory system disorder" xsd:string
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0000336
name: chromosomal aberration
def: "An irregularity in the number or structure of chromosomes, usually in the form of a gain (duplication), loss (deletion), exchange (translocation), or alteration in sequence (inversion) of genetic material." []
subset: https://www.fairsharing.org
is_a: efo:EFO_0000510 ! genetic modification
property_value: IAO:0000118 "CH" xsd:string
property_value: IAO:0000118 "ChromosomalAberration" xsd:string
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0000400
name: diabetes mellitus
def: "A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization." []
subset: https://www.fairsharing.org
is_a: OGMS:0000031 ! disease
property_value: IAO:0000118 "Diabetes" xsd:string
property_value: IAO:0000118 "diabetes" xsd:string
property_value: IAO:0000118 "diabetes mellitus" xsd:string
property_value: IAO:0000118 "diabetes mellitus (disease)" xsd:string
property_value: IAO:0000118 "Diabetes mellitus (disorder)" xsd:string
property_value: IAO:0000118 "Diabetes mellitus, NOS" xsd:string
property_value: IAO:0000118 "Diabetes NOS" xsd:string
property_value: IAO:0000118 "DM" xsd:string
property_value: IAO:0000118 "DM - Diabetes mellitus" xsd:string
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0000487
name: exposure
def: "The act of subjecting someone or something to an influencing experience. E.g. exposure to cigarette smoke" []
subset: https://www.fairsharing.org
is_a: efo:EFO_0002694 ! experimental process
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0000508
name: genetic disorder
def: "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome." []
subset: https://www.fairsharing.org
is_a: OGMS:0000031 ! disease
property_value: IAO:0000118 "genetic disease" xsd:string
property_value: IAO:0000118 "hereditary disease" xsd:string
property_value: IAO:0000118 "hereditary disease or disorder" xsd:string
property_value: IAO:0000118 "hereditary diseases" xsd:string
property_value: IAO:0000118 "inherited disease" xsd:string
property_value: IAO:0000118 "inherited genetic disease" xsd:string
property_value: IAO:0000118 "molecular disease" xsd:string
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0000510
name: genetic modification
def: "A genetic modification of the genome of  an organism which may occur naturally by spontaneous mutation, or be introduced by some experimental means. Examples of genetic modification include specification of a transgene or the gene knocked-out or details of transient transfection." []
is_a: BFO:0000015 ! process
property_value: IAO:0000118 "genetic_modification" xsd:string
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0000513
name: genotype
def: "The total sum of the genetic information of an organism that is known and relevant to the experiment being performed, including chromosomal, plasmid, viral or other genetic material which has been introduced into the organism either prior to or during the experiment." []
subset: https://www.fairsharing.org
is_a: efo:EFO_0004554 ! genomic measurement
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0000546
name: injury
def: "Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity." []
subset: https://www.fairsharing.org
is_a: BFO:0000016 ! disposition
property_value: IAO:0000118 "injury" xsd:string
property_value: IAO:0000118 "Trauma" xsd:string
property_value: IAO:0000118 "trauma" xsd:string
property_value: IAO:0000118 "traumatic injury" xsd:string
property_value: IAO:0000118 "Wound" xsd:string
property_value: IAO:0000118 "wound" xsd:string
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0000727
name: treatment
def: "A planned process intended to modify or alter a condition or characteristic of an organism or individual." []
subset: https://www.fairsharing.org
is_a: OBI:0000011 ! planned process
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0000749
name: comparative genomic hybridization by array
def: "An assay in which changes in DNA sequence copy number are analysed using a microarray. For example the analysis of LOH in tumor cells vs a non diseased sample or the comparison of clinical isolated of disease causing bacteria." []
subset: https://www.fairsharing.org
is_a: efo:EFO_0002694 ! experimental process
property_value: IAO:0000118 "CGH" xsd:string
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0001355
name: infant
subset: https://www.fairsharing.org
is_a: UBERON:0000105 ! life cycle stage
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0001444
name: measurement
def: "A measurement is an information entity that is a recording of the output of a measurement such as produced by an instrument." []
subset: https://www.fairsharing.org
is_a: IAO:0000027 ! data item
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0002694
name: experimental process
def: "A process performed as part of an experiment or wider study, i.e. intentionally designed." []
is_a: OBI:0000011 ! planned process
property_value: IAO:0000118 "Experiment" xsd:string
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0003843
name: pain
def: "An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS." []
subset: https://www.fairsharing.org
is_a: BFO:0000019 ! quality
property_value: IAO:0000118 "Ache" xsd:string
property_value: IAO:0000118 "Aches" xsd:string
property_value: IAO:0000118 "Burning Pain" xsd:string
property_value: IAO:0000118 "Burning Pains" xsd:string
property_value: IAO:0000118 "Crushing Pain" xsd:string
property_value: IAO:0000118 "Crushing Pains" xsd:string
property_value: IAO:0000118 "Migratory Pain" xsd:string
property_value: IAO:0000118 "Migratory Pains" xsd:string
property_value: IAO:0000118 "Pain, Burning" xsd:string
property_value: IAO:0000118 "Pain, Crushing" xsd:string
property_value: IAO:0000118 "Pain, Migratory" xsd:string
property_value: IAO:0000118 "Pain, Radiating" xsd:string
property_value: IAO:0000118 "Pain, Splitting" xsd:string
property_value: IAO:0000118 "Pains, Burning" xsd:string
property_value: IAO:0000118 "Pains, Crushing" xsd:string
property_value: IAO:0000118 "Pains, Migratory" xsd:string
property_value: IAO:0000118 "Pains, Radiating" xsd:string
property_value: IAO:0000118 "Pains, Splitting" xsd:string
property_value: IAO:0000118 "Physical Suffering" xsd:string
property_value: IAO:0000118 "Physical Sufferings" xsd:string
property_value: IAO:0000118 "Radiating Pain" xsd:string
property_value: IAO:0000118 "Radiating Pains" xsd:string
property_value: IAO:0000118 "Splitting Pain" xsd:string
property_value: IAO:0000118 "Splitting Pains" xsd:string
property_value: IAO:0000118 "Suffering, Physical" xsd:string
property_value: IAO:0000118 "Sufferings, Physical" xsd:string
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0003890
name: drug dependence
def: "Disorders related to drug abuse, the side effects of a medication, or toxin exposure." []
subset: https://www.fairsharing.org
is_a: OGMS:0000031 ! disease
property_value: IAO:0000118 "Abuse, Drug" xsd:string
property_value: IAO:0000118 "Addiction, Drug" xsd:string
property_value: IAO:0000118 "chemical dependence" xsd:string
property_value: IAO:0000118 "Dependence, Drug" xsd:string
property_value: IAO:0000118 "Disorder, Drug Use" xsd:string
property_value: IAO:0000118 "Drug Abuse" xsd:string
property_value: IAO:0000118 "Drug Addiction" xsd:string
property_value: IAO:0000118 "drug dependence" xsd:string
property_value: IAO:0000118 "Drug Habituation" xsd:string
property_value: IAO:0000118 "Drug Usage" xsd:string
property_value: IAO:0000118 "DRUG USE DIS" xsd:string
property_value: IAO:0000118 "Drug Use Disorder" xsd:string
property_value: IAO:0000118 "Drug Use Disorders" xsd:string
property_value: IAO:0000118 "Habituation, Drug" xsd:string
property_value: IAO:0000118 "Usage, Drug" xsd:string
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0003935
name: mental health
def: "The state wherein the person is well adjusted." []
subset: https://www.fairsharing.org
is_a: BFO:0000016 ! disposition
property_value: IAO:0000118 "Health, Mental" xsd:string
property_value: IAO:0000118 "Hygiene, Mental" xsd:string
property_value: IAO:0000118 "Mental Hygiene" xsd:string
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0004014
name: deletion
subset: https://www.fairsharing.org
is_a: efo:EFO_0000510 ! genetic modification
property_value: IAO:0000118 "DEL" xsd:string
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0004292
name: vaccination
def: "A process that involves adding vaccine into a host (e.g., human, mouse) in vivo with the intent to invoke a protective immune response." []
subset: https://www.fairsharing.org
is_a: OBI:0000011 ! planned process
property_value: IAO:0000118 "active immunization" xsd:string
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0004327
name: electrocardiography
def: "Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY." []
subset: https://www.fairsharing.org
is_a: efo:EFO_0001444 ! measurement
property_value: IAO:0000118 "EKG" xsd:string
property_value: IAO:0000118 "electrocardiogram" xsd:string
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0004346
name: neuroimaging measurement
def: "Non-invasive methods of visualizing and measuring the CENTRAL NERVOUS SYSTEM, especially the brain, by various imaging modalities e.g. CT scan" []
subset: https://www.fairsharing.org
is_a: efo:EFO_0001444 ! measurement
property_value: IAO:0000118 "brain imaging" xsd:string
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0004426
name: karyotype
def: "A karyotype is the number and appearance of chromosomes in the nucleus of a eukaryotic cell." []
subset: https://www.fairsharing.org
is_a: BFO:0000019 ! quality
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0004554
name: genomic measurement
def: "Is a quantification of some aspect of the genome, e.g. copy number variation at some locus." []
is_a: efo:EFO_0001444 ! measurement
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0004798
name: copy number variation
def: "A quantification of a genomic variation that increases or decreases the copy number of a given region." []
subset: https://www.fairsharing.org
is_a: efo:EFO_0004554 ! genomic measurement
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0004982
name: microbiome
def: "A collection or collectivity of microorganisms." []
subset: https://www.fairsharing.org
is_a: OBI:0000181 ! population
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0005135
name: strain
def: "A population of organisms that is geneticaly different from others of the same species and possessing a set of defined characteristics." []
subset: https://www.fairsharing.org
is_a: OBI:0000181 ! population
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0005741
name: infectious disease
def: "A disease whose physical basis is an infectious agent" []
subset: https://www.fairsharing.org
is_a: OGMS:0000031 ! disease
property_value: IAO:0000118 "communicable disease" xsd:string
property_value: IAO:0000118 "disease by infectious agent" xsd:string
property_value: IAO:0000118 "disorder due to infection" xsd:string
property_value: IAO:0000118 "infection" xsd:string
property_value: IAO:0000118 "infectious" xsd:string
property_value: IAO:0000118 "infectious disease" xsd:string
property_value: IAO:0000118 "infectious diseases and manifestations" xsd:string
property_value: IAO:0000118 "infectious disorder" xsd:string
property_value: IAO:0000118 "transmissible disease" xsd:string
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0007059
name: germplasm
def: "Germplasm is the living genetic resources such as seeds or tissue that is maintained for the purpose of animal and plant breeding, preservation, and other research uses. These resources may take the form of seed collections stored in seed banks, trees growing in nurseries, animal breeding lines maintained in animal breeding programs or gene banks, etc. Germplasm collections can range from collections of wild species to elite, domesticated breeding lines that have undergone extensive human selection." []
subset: https://www.fairsharing.org
is_a: OBI:0000181 ! population
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0007550
name: high content screen
def: "An image analysis technique combining automated fluorescence microscopy with multi-parameter quantitative image analysis for the large scale study of cells (cellomics)." []
subset: https://www.fairsharing.org
is_a: efo:EFO_0002694 ! experimental process
property_value: IAO:0000118 "HCS" xsd:string
property_value: IAO:0000118 "high content screening" xsd:string
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0009878
name: drug interaction
def: "Alteration of the disposition and/or effect of a drug, owing to the presence of another factor such as a second drug, or food." []
subset: https://www.fairsharing.org
is_a: MI:0000 ! molecular interaction
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0022597
name: aging
def: "A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation." []
subset: https://www.fairsharing.org
is_a: GO:0032502 ! developmental process
property_value: IAO:0000412 efo:efo.owl

[Term]
id: efo:EFO_0022599
name: DNA methylation
def: "The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." []
subset: https://www.fairsharing.org
is_a: GO:0032259 ! methylation
property_value: IAO:0000412 efo:efo.owl

[Term]
id: orpha:Orphanet_68380
name: obsolete_mitochondrial disease
subset: https://www.fairsharing.org
is_a: OGMS:0000031 ! disease
property_value: IAO:0000412 efo:efo.owl

[Term]
id: semsci:SIO_000398
name: nurse
subset: https://www.fairsharing.org
is_a: semsci:SIO_000716 ! medical practitioner
property_value: IAO:0000412 http://semanticscience.org/ontology/sio.owl

[Term]
id: semsci:SIO_000716
name: medical practitioner
is_a: BFO:0000023 ! role
property_value: IAO:0000412 http://semanticscience.org/ontology/sio.owl

[Term]
id: semsci:SIO_000983
name: gene-disease association
subset: https://www.fairsharing.org
is_a: MI:0914 ! association
property_value: IAO:0000412 http://semanticscience.org/ontology/sio.owl

[Term]
id: semsci:SIO_000993
name: chemical-disease association
subset: https://www.fairsharing.org
is_a: MI:0914 ! association
property_value: IAO:0000412 http://semanticscience.org/ontology/sio.owl

[Term]
id: semsci:SIO_000998
name: literature curation
subset: https://www.fairsharing.org
is_a: IAO:0000572 ! documenting
property_value: IAO:0000412 http://semanticscience.org/ontology/sio.owl

[Term]
id: semsci:SIO_001008
name: toxicity
subset: https://www.fairsharing.org
is_a: PATO:0001018 ! physical quality
property_value: IAO:0000412 http://semanticscience.org/ontology/sio.owl

[Term]
id: semsci:SIO_001257
name: chemical-gene association
subset: https://www.fairsharing.org
is_a: MI:0914 ! association
property_value: IAO:0000412 http://semanticscience.org/ontology/sio.owl

[Term]
id: semsci:SIO_010414
name: pathogen
subset: https://www.fairsharing.org
is_a: OBI:0100026 ! organism
property_value: IAO:0000412 http://semanticscience.org/ontology/sio.owl

[Term]
id: semsci:SIO_010423
name: target
subset: https://www.fairsharing.org
is_a: CHEBI:23367 ! molecular entity
property_value: IAO:0000412 http://semanticscience.org/ontology/sio.owl

[Term]
id: swo:SWO_0000143
name: data storage
def: "The storing of digital information. Often this is done for archiving and retrieval purposes." []
subset: https://www.fairsharing.org
is_a: BFO:0000015 ! process
property_value: IAO:0000412 http://purl.obolibrary.org/obo/swo.owl

[Term]
id: swodata:SWO_3000053
name: Knowledge representation
def: "A knowledge representation role is a role borne by a data format which utilizes formalisms to make complex systems easier to design and build. Knowledge representation is the field of artificial intelligence devoted to representing information about the world in a form that a computer system can utilize to solve complex tasks." []
subset: https://www.fairsharing.org
is_a: BFO:0000023 ! role
property_value: IAO:0000412 http://purl.obolibrary.org/obo/swo.owl

[Term]
id: swointerface:SWO_9000051
name: web service
def: "A web service is a software interface which works as a method of communication between two electronic devices over the World Wide Web and which is provided at a particular network address. There are two major classes of Web services: REST-compliant Web services, and arbitrary (or application-specific) Web services." []
subset: https://www.fairsharing.org
is_a: IAO:0000030 ! information content entity
property_value: IAO:0000118 "Web Service" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/swo.owl