diff --git a/crates/ruff_linter/resources/test/fixtures/flake8_pytest_style/PT006.py b/crates/ruff_linter/resources/test/fixtures/flake8_pytest_style/PT006.py
index af6cb50d54505..d6cbcda604e26 100644
--- a/crates/ruff_linter/resources/test/fixtures/flake8_pytest_style/PT006.py
+++ b/crates/ruff_linter/resources/test/fixtures/flake8_pytest_style/PT006.py
@@ -156,3 +156,46 @@ def test_invalid_argvalues(param):
     ------------------------------------------------
     """
     ...
+
+
+# Regression tests for nested tuples that could cause syntax errors when unpacked.
+# See: https://github.com/astral-sh/ruff/issues/22441
+@pytest.mark.parametrize(
+    ["param"],
+    [
+        ((),),
+        ((1,),),
+    ],
+)
+def test_single_element_nested_empty_tuple(param):
+    ...
+
+
+@pytest.mark.parametrize(
+    ["param"],
+    [
+        ((1, 2),),
+        ((3, 4),),
+    ],
+)
+def test_single_element_nested_multi_tuple(param):
+    ...
+
+
+@pytest.mark.parametrize(
+    ["param"],
+    [
+        (((1,),),),
+    ],
+)
+def test_single_element_deeply_nested_tuple(param):
+    ...
+
+
+@pytest.mark.parametrize(
+    ["param"],
+    [
+        (((1,)),),
+    ],
+)
+def test_single_element_grouped_tuple(param): ...
diff --git a/crates/ruff_linter/src/rules/flake8_pytest_style/rules/parametrize.rs b/crates/ruff_linter/src/rules/flake8_pytest_style/rules/parametrize.rs
index 904ca1c494dd2..6c72ef28404fe 100644
--- a/crates/ruff_linter/src/rules/flake8_pytest_style/rules/parametrize.rs
+++ b/crates/ruff_linter/src/rules/flake8_pytest_style/rules/parametrize.rs
@@ -705,7 +705,8 @@ fn handle_single_name(checker: &Checker, argnames: &Expr, value: &Expr, argvalue
     //     assert isinstance(x, int)  # fails because `x` is a tuple, not an int
     // ```
     let argvalues_edits = unpack_single_element_items(checker, argvalues);
-    let argnames_edit = Edit::range_replacement(checker.generator().expr(value), argnames.range());
+    let argnames_edit =
+        Edit::range_replacement(unparse_expr_in_sequence(value, checker), argnames.range());
     let fix = if checker.comment_ranges().intersects(argnames_edit.range())
         || argvalues_edits
             .iter()
@@ -743,13 +744,23 @@ fn unpack_single_element_items(checker: &Checker, expr: &Expr) -> Vec<Edit> {
         }
 
         edits.push(Edit::range_replacement(
-            checker.generator().expr(elt),
+            unparse_expr_in_sequence(elt, checker),
             value.range(),
         ));
     }
     edits
 }
 
+fn unparse_expr_in_sequence(expr: &Expr, checker: &Checker) -> String {
+    let content = checker.locator().slice(expr);
+    if let Expr::Tuple(tuple) = expr {
+        if !tuple.is_empty() && !tuple.parenthesized {
+            return format!("({content})");
+        }
+    }
+    content.to_string()
+}
+
 fn handle_value_rows(
     checker: &Checker,
     elts: &[Expr],
diff --git a/crates/ruff_linter/src/rules/flake8_pytest_style/snapshots/ruff_linter__rules__flake8_pytest_style__tests__PT006_csv.snap b/crates/ruff_linter/src/rules/flake8_pytest_style/snapshots/ruff_linter__rules__flake8_pytest_style__tests__PT006_csv.snap
index ba76432fe169f..69f3a38d3631f 100644
--- a/crates/ruff_linter/src/rules/flake8_pytest_style/snapshots/ruff_linter__rules__flake8_pytest_style__tests__PT006_csv.snap
+++ b/crates/ruff_linter/src/rules/flake8_pytest_style/snapshots/ruff_linter__rules__flake8_pytest_style__tests__PT006_csv.snap
@@ -252,3 +252,96 @@ help: Use a string for the first argument
 143 |     [
 144 |         (1,),
 145 |         (2, 3),
+
+PT006 [*] Wrong type passed to first argument of `pytest.mark.parametrize`; expected `str`
+   --> PT006.py:164:5
+    |
+162 | # See: https://github.com/astral-sh/ruff/issues/22441
+163 | @pytest.mark.parametrize(
+164 |     ["param"],
+    |     ^^^^^^^^^
+165 |     [
+166 |         ((),),
+    |
+help: Use a string for the first argument
+161 | # Regression tests for nested tuples that could cause syntax errors when unpacked.
+162 | # See: https://github.com/astral-sh/ruff/issues/22441
+163 | @pytest.mark.parametrize(
+    -     ["param"],
+164 +     "param",
+165 |     [
+    -         ((),),
+    -         ((1,),),
+166 +         (),
+167 +         (1,),
+168 |     ],
+169 | )
+170 | def test_single_element_nested_empty_tuple(param):
+
+PT006 [*] Wrong type passed to first argument of `pytest.mark.parametrize`; expected `str`
+   --> PT006.py:175:5
+    |
+174 | @pytest.mark.parametrize(
+175 |     ["param"],
+    |     ^^^^^^^^^
+176 |     [
+177 |         ((1, 2),),
+    |
+help: Use a string for the first argument
+172 | 
+173 | 
+174 | @pytest.mark.parametrize(
+    -     ["param"],
+175 +     "param",
+176 |     [
+    -         ((1, 2),),
+    -         ((3, 4),),
+177 +         (1, 2),
+178 +         (3, 4),
+179 |     ],
+180 | )
+181 | def test_single_element_nested_multi_tuple(param):
+
+PT006 [*] Wrong type passed to first argument of `pytest.mark.parametrize`; expected `str`
+   --> PT006.py:186:5
+    |
+185 | @pytest.mark.parametrize(
+186 |     ["param"],
+    |     ^^^^^^^^^
+187 |     [
+188 |         (((1,),),),
+    |
+help: Use a string for the first argument
+183 | 
+184 | 
+185 | @pytest.mark.parametrize(
+    -     ["param"],
+186 +     "param",
+187 |     [
+    -         (((1,),),),
+188 +         ((1,),),
+189 |     ],
+190 | )
+191 | def test_single_element_deeply_nested_tuple(param):
+
+PT006 [*] Wrong type passed to first argument of `pytest.mark.parametrize`; expected `str`
+   --> PT006.py:196:5
+    |
+195 | @pytest.mark.parametrize(
+196 |     ["param"],
+    |     ^^^^^^^^^
+197 |     [
+198 |         (((1,)),),
+    |
+help: Use a string for the first argument
+193 | 
+194 | 
+195 | @pytest.mark.parametrize(
+    -     ["param"],
+196 +     "param",
+197 |     [
+    -         (((1,)),),
+198 +         (1,),
+199 |     ],
+200 | )
+201 | def test_single_element_grouped_tuple(param): ...
diff --git a/crates/ruff_linter/src/rules/flake8_pytest_style/snapshots/ruff_linter__rules__flake8_pytest_style__tests__PT006_default.snap b/crates/ruff_linter/src/rules/flake8_pytest_style/snapshots/ruff_linter__rules__flake8_pytest_style__tests__PT006_default.snap
index 518ee826db78e..6aed32ccc7e1b 100644
--- a/crates/ruff_linter/src/rules/flake8_pytest_style/snapshots/ruff_linter__rules__flake8_pytest_style__tests__PT006_default.snap
+++ b/crates/ruff_linter/src/rules/flake8_pytest_style/snapshots/ruff_linter__rules__flake8_pytest_style__tests__PT006_default.snap
@@ -422,3 +422,96 @@ help: Use a string for the first argument
 143 |     [
 144 |         (1,),
 145 |         (2, 3),
+
+PT006 [*] Wrong type passed to first argument of `pytest.mark.parametrize`; expected `str`
+   --> PT006.py:164:5
+    |
+162 | # See: https://github.com/astral-sh/ruff/issues/22441
+163 | @pytest.mark.parametrize(
+164 |     ["param"],
+    |     ^^^^^^^^^
+165 |     [
+166 |         ((),),
+    |
+help: Use a string for the first argument
+161 | # Regression tests for nested tuples that could cause syntax errors when unpacked.
+162 | # See: https://github.com/astral-sh/ruff/issues/22441
+163 | @pytest.mark.parametrize(
+    -     ["param"],
+164 +     "param",
+165 |     [
+    -         ((),),
+    -         ((1,),),
+166 +         (),
+167 +         (1,),
+168 |     ],
+169 | )
+170 | def test_single_element_nested_empty_tuple(param):
+
+PT006 [*] Wrong type passed to first argument of `pytest.mark.parametrize`; expected `str`
+   --> PT006.py:175:5
+    |
+174 | @pytest.mark.parametrize(
+175 |     ["param"],
+    |     ^^^^^^^^^
+176 |     [
+177 |         ((1, 2),),
+    |
+help: Use a string for the first argument
+172 | 
+173 | 
+174 | @pytest.mark.parametrize(
+    -     ["param"],
+175 +     "param",
+176 |     [
+    -         ((1, 2),),
+    -         ((3, 4),),
+177 +         (1, 2),
+178 +         (3, 4),
+179 |     ],
+180 | )
+181 | def test_single_element_nested_multi_tuple(param):
+
+PT006 [*] Wrong type passed to first argument of `pytest.mark.parametrize`; expected `str`
+   --> PT006.py:186:5
+    |
+185 | @pytest.mark.parametrize(
+186 |     ["param"],
+    |     ^^^^^^^^^
+187 |     [
+188 |         (((1,),),),
+    |
+help: Use a string for the first argument
+183 | 
+184 | 
+185 | @pytest.mark.parametrize(
+    -     ["param"],
+186 +     "param",
+187 |     [
+    -         (((1,),),),
+188 +         ((1,),),
+189 |     ],
+190 | )
+191 | def test_single_element_deeply_nested_tuple(param):
+
+PT006 [*] Wrong type passed to first argument of `pytest.mark.parametrize`; expected `str`
+   --> PT006.py:196:5
+    |
+195 | @pytest.mark.parametrize(
+196 |     ["param"],
+    |     ^^^^^^^^^
+197 |     [
+198 |         (((1,)),),
+    |
+help: Use a string for the first argument
+193 | 
+194 | 
+195 | @pytest.mark.parametrize(
+    -     ["param"],
+196 +     "param",
+197 |     [
+    -         (((1,)),),
+198 +         (1,),
+199 |     ],
+200 | )
+201 | def test_single_element_grouped_tuple(param): ...
diff --git a/crates/ruff_linter/src/rules/flake8_pytest_style/snapshots/ruff_linter__rules__flake8_pytest_style__tests__PT006_list.snap b/crates/ruff_linter/src/rules/flake8_pytest_style/snapshots/ruff_linter__rules__flake8_pytest_style__tests__PT006_list.snap
index 9c6fa17b1f670..a0729b05d94f3 100644
--- a/crates/ruff_linter/src/rules/flake8_pytest_style/snapshots/ruff_linter__rules__flake8_pytest_style__tests__PT006_list.snap
+++ b/crates/ruff_linter/src/rules/flake8_pytest_style/snapshots/ruff_linter__rules__flake8_pytest_style__tests__PT006_list.snap
@@ -384,3 +384,96 @@ help: Use a string for the first argument
 143 |     [
 144 |         (1,),
 145 |         (2, 3),
+
+PT006 [*] Wrong type passed to first argument of `pytest.mark.parametrize`; expected `str`
+   --> PT006.py:164:5
+    |
+162 | # See: https://github.com/astral-sh/ruff/issues/22441
+163 | @pytest.mark.parametrize(
+164 |     ["param"],
+    |     ^^^^^^^^^
+165 |     [
+166 |         ((),),
+    |
+help: Use a string for the first argument
+161 | # Regression tests for nested tuples that could cause syntax errors when unpacked.
+162 | # See: https://github.com/astral-sh/ruff/issues/22441
+163 | @pytest.mark.parametrize(
+    -     ["param"],
+164 +     "param",
+165 |     [
+    -         ((),),
+    -         ((1,),),
+166 +         (),
+167 +         (1,),
+168 |     ],
+169 | )
+170 | def test_single_element_nested_empty_tuple(param):
+
+PT006 [*] Wrong type passed to first argument of `pytest.mark.parametrize`; expected `str`
+   --> PT006.py:175:5
+    |
+174 | @pytest.mark.parametrize(
+175 |     ["param"],
+    |     ^^^^^^^^^
+176 |     [
+177 |         ((1, 2),),
+    |
+help: Use a string for the first argument
+172 | 
+173 | 
+174 | @pytest.mark.parametrize(
+    -     ["param"],
+175 +     "param",
+176 |     [
+    -         ((1, 2),),
+    -         ((3, 4),),
+177 +         (1, 2),
+178 +         (3, 4),
+179 |     ],
+180 | )
+181 | def test_single_element_nested_multi_tuple(param):
+
+PT006 [*] Wrong type passed to first argument of `pytest.mark.parametrize`; expected `str`
+   --> PT006.py:186:5
+    |
+185 | @pytest.mark.parametrize(
+186 |     ["param"],
+    |     ^^^^^^^^^
+187 |     [
+188 |         (((1,),),),
+    |
+help: Use a string for the first argument
+183 | 
+184 | 
+185 | @pytest.mark.parametrize(
+    -     ["param"],
+186 +     "param",
+187 |     [
+    -         (((1,),),),
+188 +         ((1,),),
+189 |     ],
+190 | )
+191 | def test_single_element_deeply_nested_tuple(param):
+
+PT006 [*] Wrong type passed to first argument of `pytest.mark.parametrize`; expected `str`
+   --> PT006.py:196:5
+    |
+195 | @pytest.mark.parametrize(
+196 |     ["param"],
+    |     ^^^^^^^^^
+197 |     [
+198 |         (((1,)),),
+    |
+help: Use a string for the first argument
+193 | 
+194 | 
+195 | @pytest.mark.parametrize(
+    -     ["param"],
+196 +     "param",
+197 |     [
+    -         (((1,)),),
+198 +         (1,),
+199 |     ],
+200 | )
+201 | def test_single_element_grouped_tuple(param): ...