-
Notifications
You must be signed in to change notification settings - Fork 8
Expand file tree
/
Copy pathPMC212558_t.ttl
More file actions
2274 lines (2270 loc) · 137 KB
/
PMC212558_t.ttl
File metadata and controls
2274 lines (2270 loc) · 137 KB
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
571
572
573
574
575
576
577
578
579
580
581
582
583
584
585
586
587
588
589
590
591
592
593
594
595
596
597
598
599
600
601
602
603
604
605
606
607
608
609
610
611
612
613
614
615
616
617
618
619
620
621
622
623
624
625
626
627
628
629
630
631
632
633
634
635
636
637
638
639
640
641
642
643
644
645
646
647
648
649
650
651
652
653
654
655
656
657
658
659
660
661
662
663
664
665
666
667
668
669
670
671
672
673
674
675
676
677
678
679
680
681
682
683
684
685
686
687
688
689
690
691
692
693
694
695
696
697
698
699
700
701
702
703
704
705
706
707
708
709
710
711
712
713
714
715
716
717
718
719
720
721
722
723
724
725
726
727
728
729
730
731
732
733
734
735
736
737
738
739
740
741
742
743
744
745
746
747
748
749
750
751
752
753
754
755
756
757
758
759
760
761
762
763
764
765
766
767
768
769
770
771
772
773
774
775
776
777
778
779
780
781
782
783
784
785
786
787
788
789
790
791
792
793
794
795
796
797
798
799
800
801
802
803
804
805
806
807
808
809
810
811
812
813
814
815
816
817
818
819
820
821
822
823
824
825
826
827
828
829
830
831
832
833
834
835
836
837
838
839
840
841
842
843
844
845
846
847
848
849
850
851
852
853
854
855
856
857
858
859
860
861
862
863
864
865
866
867
868
869
870
871
872
873
874
875
876
877
878
879
880
881
882
883
884
885
886
887
888
889
890
891
892
893
894
895
896
897
898
899
900
901
902
903
904
905
906
907
908
909
910
911
912
913
914
915
916
917
918
919
920
921
922
923
924
925
926
927
928
929
930
931
932
933
934
935
936
937
938
939
940
941
942
943
944
945
946
947
948
949
950
951
952
953
954
955
956
957
958
959
960
961
962
963
964
965
966
967
968
969
970
971
972
973
974
975
976
977
978
979
980
981
982
983
984
985
986
987
988
989
990
991
992
993
994
995
996
997
998
999
1000
@prefix ns1: <https://www.ncbi.nlm.nih.gov/pmc/articles/#$> .
@prefix pmc: <https://www.ncbi.nlm.nih.gov/pmc/articles/#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xml: <http://www.w3.org/XML/1998/namespace> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix sso: <http://semanticscholar.org/cv-research/> .
@prefix fhir: <http://hl7.org/fhir/>
<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC212558> pmc:_id "12969506|PMC212558" ;
dc:identifier <https://www.ncbi.nlm.nih.gov/pubmed/32125455>,
<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC212558>;
fhir:link <https://fhircat.org/cord-19/fhir/Non-comercial/Composition/0104f6ceccf92ae8567a0102f89cbb976969a774> ;
pmc:accessions "chemical@MESH:D003401",
"chemical@MESH:D004492",
"chemical@MESH:D006514",
"disease@MESH:D001008",
"disease@MESH:D001327",
"disease@MESH:D003141",
"disease@MESH:D003327",
"disease@MESH:D004487",
"disease@MESH:D005334",
"disease@MESH:D007239",
"disease@MESH:D007676",
"disease@MESH:D007877",
"disease@MESH:D007918",
"disease@MESH:D008171",
"disease@MESH:D008231",
"disease@MESH:D008288",
"disease@MESH:D010437",
"disease@MESH:D011014",
"disease@MESH:D012131",
"disease@MESH:D014376",
"disease@MESH:D015004",
"disease@MESH:D015658",
"disease@MESH:D018352",
"disease@MESH:D045169",
"disease@MESH:D051436",
"disease@MESH:D056486",
"gene@1401",
"gene@26503",
"gene@3105",
"gene@3105;3106",
"gene@3106",
"gene@3123",
"gene@4698",
"gene@6301",
"species@12637",
"species@1313",
"species@227859",
"species@31631",
"species@813",
"species@83554",
"species@83558",
"species@9606" ;
pmc:authors "Chen PJ",
"Chu CC",
"Huang CH",
"Lee HL",
"Lim KH",
"Lin M",
"Lin RS",
"Lin RY",
"Loo JH",
"Su YW",
"Trejaut JA",
"Tsai ZU",
"Tseng HK" ;
pmc:created [ ns1:date "1572689280000.0"^^xsd:float ] ;
pmc:id "212558" ;
pmc:infons [ ] ;
pmc:journal "BMC Med. Genet." ;
pmc:passages [ pmc:infons [ pmc:section "Abstract" ;
pmc:section_type "ABSTRACT" ;
pmc:type "abstract_title_1" ] ;
pmc:offset "623"^^xsd:int ;
pmc:text "Methods" ],
[ pmc:annotations [ pmc:id "194" ;
pmc:infons [ pmc:identifier "MESH:D006514" ;
pmc:type "Chemical" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "10449"^^xsd:int ] ;
pmc:text "HBsAg" ],
[ pmc:id "189" ;
pmc:infons [ pmc:identifier "26503" ;
pmc:ncbi_homologene "56571" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "3"^^xsd:int ;
pmc:offset "10344"^^xsd:int ] ;
pmc:text "AST" ],
[ pmc:id "195" ;
pmc:infons [ pmc:identifier "MESH:D003401" ;
pmc:type "Chemical" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "10298"^^xsd:int ] ;
pmc:text "creatine" ],
[ pmc:id "192" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "10088"^^xsd:int ] ;
pmc:text "patients" ],
[ pmc:id "191" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "9717"^^xsd:int ] ;
pmc:text "patients" ],
[ pmc:id "190" ;
pmc:infons [ pmc:identifier "1401" ;
pmc:ncbi_homologene "128039" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "18"^^xsd:int ;
pmc:offset "10393"^^xsd:int ] ;
pmc:text "C-reactive protein" ],
[ pmc:id "193" ;
pmc:infons [ pmc:identifier "MESH:D008231" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "15"^^xsd:int ;
pmc:offset "10204"^^xsd:int ] ;
pmc:text "lymphocytopenia" ] ;
pmc:infons [ pmc:section "Methods" ;
pmc:section_type "METHODS" ;
pmc:type "paragraph" ] ;
pmc:offset "9688"^^xsd:int ;
pmc:text "Clinical symptoms, of the 37 patients diagnosed as probable SARS cases, were as follows: 92% (34 cases) showed diffuse infiltration of both lungs and 8% (3 cases) showed only solitary lung lesion; 65% (24 cases) showed at least one positive test result for SARS-CoV RNA by RT-PCR or by real time PCR (Artus, Germany). In addition, the following laboratory data was obtained from the 35 probable SARS patients managed in our hospital: 27% (10 cases) with reduced platelet count (<150x10-9/liter), 59% (22 cases) with lymphocytopenia (<1x10-9/liter), 70% (26 cases) with elevated LDH, 5% (2 cases) with elevated creatine kinase, 54% (20 cases) with elevated AST and /or ALT and 68% (25 cases) with elevated C-reactive protein. Fourteen cases were also tested for HBsAg, all showed negative results." ],
[ pmc:annotations [ pmc:id "493" ;
pmc:infons [ pmc:identifier "MESH:D015658" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "39"^^xsd:int ;
pmc:offset "25219"^^xsd:int ] ;
pmc:text "immunodeficiency virus type 1 infection" ],
[ pmc:id "492" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "25105"^^xsd:int ] ;
pmc:text "human" ] ;
pmc:infons [ pmc:fpage "1404" ;
pmc:lpage "1410" ;
pmc:name_0 "surname:Liu;given-names:C" ;
pmc:name_1 "surname:Carrington;given-names:M" ;
pmc:name_2 "surname:Kaslow;given-names:RA" ;
pmc:name_3 "surname:Gao;given-names:X" ;
pmc:name_4 "surname:Rinaldo;given-names:CR" ;
pmc:name_5 "surname:Jacobson;given-names:LP" ;
pmc:name_6 "surname:Margolick;given-names:JB" ;
pmc:name_7 "surname:Phair;given-names:J" ;
pmc:name_8 "surname:O'Brien;given-names:SJ" ;
pmc:name_9 "surname:Detels;given-names:R" ;
pmc:pub-id_doi "10.1086/374394" ;
pmc:pub-id_pmid "12717621" ;
pmc:section "Pre-publication history" ;
pmc:section_type "REF" ;
pmc:source "J Infect Dis" ;
pmc:type "ref" ;
pmc:volume "187" ;
pmc:year "2003" ] ;
pmc:offset "25073"^^xsd:int ;
pmc:text "Association of polymorphisms in human leukocyte antigen class I and transporter associated with antigen processing genes with resistance to human immunodeficiency virus type 1 infection" ],
[ pmc:annotations [ pmc:id "485" ;
pmc:infons [ pmc:identifier "3123" ;
pmc:ncbi_homologene "136635" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "3"^^xsd:int ;
pmc:offset "24865"^^xsd:int ] ;
pmc:text "HLA" ] ;
pmc:infons [ pmc:fpage "407" ;
pmc:lpage "464" ;
pmc:name_0 "surname:Marsh;given-names:SGE" ;
pmc:name_1 "surname:Albert;given-names:ED" ;
pmc:name_2 "surname:Bodmer;given-names:WF" ;
pmc:name_3 "surname:Bontrop;given-names:RE" ;
pmc:name_4 "surname:Dupont;given-names:B" ;
pmc:name_5 "surname:Erlich;given-names:HA" ;
pmc:name_6 "surname:Gerahty;given-names:DE" ;
pmc:name_7 "surname:Hansen;given-names:JA" ;
pmc:name_8 "surname:Mach;given-names:B" ;
pmc:name_9 "surname:Mayr;given-names:WR" ;
pmc:pub-id_doi "10.1034/j.1399-0039.2002.600509.x" ;
pmc:pub-id_pmid "12492818" ;
pmc:section "Pre-publication history" ;
pmc:section_type "REF" ;
pmc:source "Tissue Antigens" ;
pmc:type "ref" ;
pmc:volume "60" ;
pmc:year "2002" ] ;
pmc:offset "24833"^^xsd:int ;
pmc:text "Nomenclature for factors of the HLA system, 2002" ],
[ pmc:annotations [ pmc:id "235" ;
pmc:infons [ pmc:identifier "MESH:D007239" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "9"^^xsd:int ;
pmc:offset "12517"^^xsd:int ] ;
pmc:text "infection" ],
[ pmc:id "234" ;
pmc:infons [ pmc:identifier "MESH:D007239" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "9"^^xsd:int ;
pmc:offset "12755"^^xsd:int ] ;
pmc:text "infection" ],
[ pmc:id "233" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "12699"^^xsd:int ] ;
pmc:text "patients" ],
[ pmc:id "232" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "7"^^xsd:int ;
pmc:offset "12316"^^xsd:int ] ;
pmc:text "patient" ] ;
pmc:infons [ pmc:section "Methods" ;
pmc:section_type "METHODS" ;
pmc:type "paragraph" ] ;
pmc:offset "12051"^^xsd:int ;
pmc:text "Blood samples were obtained at the end of May 2003 from 62 health care workers who had possibly been exposed to coronavirus and were not infected. These 62 health care workers were either working at emergency services, SARS wards (doctors and nurses) or at the out patient clinic (phlebotomists) of our hospital in May 2003. These 62 health care workers were included in control A (table 2) and had followed World Health Organization (WHO) vigorous measures against infection. Another 39 blood samples from non-infected health care workers from the Taipei Municipal Hoping Hospital were added to control A. These 39 controls had been treating SARS patients in April 2003 without adequate protection from infection, and about 10% of health care workers from the same wards developed probable SARS. In brief, 101 high risk non-infected health care workers were retained as control A for the analysis. Informed consent was obtained from all subjects." ],
[ pmc:annotations [ pmc:id "257" ;
pmc:infons [ pmc:identifier "MESH:D004492" ;
pmc:type "Chemical" ] ;
pmc:locations [ pmc:length "4"^^xsd:int ;
pmc:offset "13371"^^xsd:int ] ;
pmc:text "EDTA" ],
[ pmc:id "256" ;
pmc:infons [ pmc:identifier "3123" ;
pmc:ncbi_homologene "136635" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "13953"^^xsd:int ] ;
pmc:text "HLA-DRB1" ],
[ pmc:id "255" ;
pmc:infons [ pmc:identifier "3106" ;
pmc:ncbi_homologene "134029" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "13935"^^xsd:int ] ;
pmc:text "HLA-B" ],
[ pmc:id "254" ;
pmc:infons [ pmc:identifier "3105" ;
pmc:ncbi_homologene "128352" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "13921"^^xsd:int ] ;
pmc:text "HLA-A" ],
[ pmc:id "253" ;
pmc:infons [ pmc:identifier "3123" ;
pmc:ncbi_homologene "136635" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "4"^^xsd:int ;
pmc:offset "13689"^^xsd:int ] ;
pmc:text "DRB1" ],
[ pmc:id "252" ;
pmc:infons [ pmc:identifier "3105" ;
pmc:ncbi_homologene "128352" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "13676"^^xsd:int ] ;
pmc:text "HLA-A" ] ;
pmc:infons [ pmc:section "Methods" ;
pmc:section_type "METHODS" ;
pmc:type "paragraph" ] ;
pmc:offset "13339"^^xsd:int ;
pmc:text "Blood samples were collected in EDTA vacutainers. Buffy coat were lysed and genomic DNA was isolated by using proteinase K treatment and Q1Aamp blood kit (Q1Agen, Hilden, Germany) according to the manufacturer's instructions. Suspected SARS samples were processed in a bio-safety level-3 environment. Medium resolution allele typing for HLA-A, B and DRB1 loci was performed using PCR amplification followed by sequence-specific oligonucleotide probing (PCR-SSOP), (Dynal Biotech Ltd; Wirral, U.K.). Amplified sequences were hybridized to arrays of immobilized probes (35 probes for HLA-A, 56 for HLA-B, and 38 for HLA-DRB1)." ],
[ pmc:annotations [ pmc:id "155" ;
pmc:infons [ pmc:type "Chemical" ] ;
pmc:locations [ pmc:length "7"^^xsd:int ;
pmc:offset "7669"^^xsd:int ] ;
pmc:text "Haldane" ],
[ pmc:id "154" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "7593"^^xsd:int ] ;
pmc:text "patients" ],
[ pmc:id "153" ;
pmc:infons [ pmc:identifier "3105;3106" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "11"^^xsd:int ;
pmc:offset "7465"^^xsd:int ] ;
pmc:text "HLA-A and B" ] ;
pmc:infons [ pmc:section "Methods" ;
pmc:section_type "TABLE" ;
pmc:type "table" ] ;
pmc:offset "7413"^^xsd:int ;
pmc:text "P = P-value n.s. = not significant. In control B, HLA-A and B were defined by serological methods. Consequently data were re-analyzed after converting allotypes of probable SARS patients to their serological equivalents. Odds ratio (OR) refers to Woolf-Haldane odds ratios, with 95% Woolf approximation confidence intervals (CI) and corresponding two tails Fisher P-values. Note: No corrected P-values (Pc-values) were significant; consequently Pc-values were not indicated." ],
[ pmc:infons [ pmc:section "Methods" ;
pmc:section_type "METHODS" ;
pmc:type "title_2" ] ;
pmc:offset "4024"^^xsd:int ;
pmc:text "Patients" ],
[ pmc:infons [ pmc:fpage "1" ;
pmc:lpage "9" ;
pmc:name_0 "surname:Lin;given-names:M" ;
pmc:name_1 "surname:Chu;given-names:CC" ;
pmc:name_2 "surname:Lee;given-names:HL" ;
pmc:name_3 "surname:Chang;given-names:SL" ;
pmc:name_4 "surname:Ohashi;given-names:J" ;
pmc:name_5 "surname:Tokunaga;given-names:K" ;
pmc:name_6 "surname:Akaza;given-names:T" ;
pmc:name_7 "surname:Juji;given-names:T" ;
pmc:pub-id_doi "10.1034/j.1399-0039.2000.550101.x" ;
pmc:pub-id_pmid "10703601" ;
pmc:section "Pre-publication history" ;
pmc:section_type "REF" ;
pmc:source "Tissue Antigens" ;
pmc:type "ref" ;
pmc:volume "55" ;
pmc:year "2000" ] ;
pmc:offset "24882"^^xsd:int ;
pmc:text "Heterogeneity of Taiwan's indigenous population: possible relation to prehistoric mongoloid dispersals" ],
[ pmc:annotations [ pmc:id "465" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "7"^^xsd:int ;
pmc:offset "22836"^^xsd:int ] ;
pmc:text "peoples" ],
[ pmc:id "474" ;
pmc:infons [ pmc:identifier "MESH:D007239" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "9"^^xsd:int ;
pmc:offset "22951"^^xsd:int ] ;
pmc:text "infection" ],
[ pmc:id "470" ;
pmc:infons [ pmc:identifier "3123" ;
pmc:ncbi_homologene "136635" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "3"^^xsd:int ;
pmc:offset "24026"^^xsd:int ] ;
pmc:text "HLA" ],
[ pmc:id "469" ;
pmc:infons [ pmc:identifier "3123" ;
pmc:ncbi_homologene "136635" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "3"^^xsd:int ;
pmc:offset "24051"^^xsd:int ] ;
pmc:text "HLA" ],
[ pmc:id "468" ;
pmc:infons [ pmc:identifier "227859" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "16"^^xsd:int ;
pmc:offset "23996"^^xsd:int ] ;
pmc:text "SARS coronavirus" ],
[ pmc:id "464" ;
pmc:infons [ pmc:identifier "3123" ;
pmc:ncbi_homologene "136635" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "3"^^xsd:int ;
pmc:offset "23191"^^xsd:int ] ;
pmc:text "HLA" ],
[ pmc:id "473" ;
pmc:infons [ pmc:identifier "MESH:D018352" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "26"^^xsd:int ;
pmc:offset "23777"^^xsd:int ] ;
pmc:text "SARS coronavirus infection" ],
[ pmc:id "472" ;
pmc:infons [ pmc:identifier "MESH:D001008" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "7"^^xsd:int ;
pmc:offset "24251"^^xsd:int ] ;
pmc:text "anxiety" ],
[ pmc:id "461" ;
pmc:infons [ pmc:identifier "3106" ;
pmc:ncbi_homologene "134029" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "22608"^^xsd:int ] ;
pmc:text "HLA-B" ],
[ pmc:id "466" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "7"^^xsd:int ;
pmc:offset "23005"^^xsd:int ] ;
pmc:text "peoples" ],
[ pmc:id "467" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "7"^^xsd:int ;
pmc:offset "23093"^^xsd:int ] ;
pmc:text "peoples" ],
[ pmc:id "471" ;
pmc:infons [ pmc:identifier "MESH:D018352" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "29"^^xsd:int ;
pmc:offset "23666"^^xsd:int ] ;
pmc:text "infection of SARS coronavirus" ],
[ pmc:id "463" ;
pmc:infons [ pmc:identifier "3123" ;
pmc:ncbi_homologene "136635" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "3"^^xsd:int ;
pmc:offset "23726"^^xsd:int ] ;
pmc:text "HLA" ],
[ pmc:id "475" ;
pmc:infons [ pmc:identifier "MESH:D007239" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "9"^^xsd:int ;
pmc:offset "24181"^^xsd:int ] ;
pmc:text "infection" ],
[ pmc:id "462" ;
pmc:infons [ pmc:identifier "3106" ;
pmc:ncbi_homologene "134029" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "22852"^^xsd:int ] ;
pmc:text "HLA-B" ] ;
pmc:infons [ pmc:section "Discussion" ;
pmc:section_type "DISCUSS" ;
pmc:type "paragraph" ] ;
pmc:offset "22581"^^xsd:int ;
pmc:text "The presence or absence of HLA-B* 4601 in a population appeared to be an important element that acted during the outbreak of the SARS epidemic. Certainly, further independent studies are still needed to confirm this hypothesis. However, Taiwan indigenous peoples have no HLA-B* 4601 and have very low population density. This does not exclude that they may have avoided infection only by chance, even though many indigenous peoples are now urbanized and would have run the same risk as Taiwanese. Southern Asian peoples, not only live in highly densely populated regions, but also have less variation in their HLA related immune repertoires than European or African populations [Variation was inferred here from the heterozygosity (h = 1 - sum of squares of allele frequencies) seen in these populations, and h was obtained and calculated (data not shown) from published data [18]], which as a whole creates a favorable factor for rapid settling of any epidemic. It becomes evident that authorities must keep a state of disease awareness at all times. Little is known on the routes of infection of SARS coronavirus. In this study, the effect of HLA alleles on the resistance or susceptibility to SARS coronavirus infection was shown to be associated to class I alleles. No association with class II alleles was seen. Quickly establishing a procedure of mass screening for health care workers at risk of exposure to SARS coronavirus by detecting HLA-B* 4601 and possibly HLA-B* 1301 alleles appears justified. The results of such screening would help hospitals to better guard their personals against infection, make the workplace safer, and help to ease the tension and anxiety seen in the hospital environment." ],
[ pmc:annotations [ pmc:id "295" ;
pmc:infons [ pmc:identifier "3106" ;
pmc:ncbi_homologene "134029" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "16147"^^xsd:int ] ;
pmc:text "HLA-B" ],
[ pmc:id "299" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "15612"^^xsd:int ] ;
pmc:text "patients" ],
[ pmc:id "301" ;
pmc:infons [ pmc:identifier "3123" ;
pmc:ncbi_homologene "136635" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "3"^^xsd:int ;
pmc:offset "15695"^^xsd:int ] ;
pmc:text "HLA" ],
[ pmc:id "293" ;
pmc:infons [ pmc:identifier "3106" ;
pmc:ncbi_homologene "134029" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "15881"^^xsd:int ] ;
pmc:text "HLA-B" ],
[ pmc:id "296" ;
pmc:infons [ pmc:identifier "3106" ;
pmc:ncbi_homologene "134029" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "16276"^^xsd:int ] ;
pmc:text "HLA-B" ],
[ pmc:id "302" ;
pmc:infons [ pmc:identifier "MESH:D007239" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "9"^^xsd:int ;
pmc:offset "15682"^^xsd:int ] ;
pmc:text "infection" ],
[ pmc:id "297" ;
pmc:infons [ pmc:identifier "3106" ;
pmc:ncbi_homologene "134029" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "16374"^^xsd:int ] ;
pmc:text "HLA-B" ],
[ pmc:id "300" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "15977"^^xsd:int ] ;
pmc:text "patients" ],
[ pmc:id "303" ;
pmc:infons [ pmc:identifier "MESH:D005334" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "15606"^^xsd:int ] ;
pmc:text "fever" ],
[ pmc:id "294" ;
pmc:infons [ pmc:identifier "3106" ;
pmc:ncbi_homologene "134029" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "16087"^^xsd:int ] ;
pmc:text "HLA-B" ],
[ pmc:id "298" ;
pmc:infons [ pmc:identifier "3123" ;
pmc:ncbi_homologene "136635" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "3"^^xsd:int ;
pmc:offset "16111"^^xsd:int ] ;
pmc:text "HLA" ] ;
pmc:infons [ pmc:section "Results" ;
pmc:section_type "RESULTS" ;
pmc:type "paragraph" ] ;
pmc:offset "15534"^^xsd:int ;
pmc:text "Analysis between 33 retained unrelated probable SARS cases, 28 excluded fever patients, and two control groups (table 2) showed weak association to infection of HLA class I alleles (B* 4601, OR = 2.08, P = 0.04, Pc = n.s. and B* 5401, OR = 5.44, P = 0.02, Pc = n.s. with control A; and B* 3901/B39, OR = 3.81, P = 0.03, Pc = n.s. with control B). HLA-B* 4601 was not significant (n.s.) when testing analogous serotypes of the 33 probable SARS patients against the 190 healthy unrelated Taiwanese of control B (OR = 1.86, P = 0.06, Pc = n.s.) (table 2). HLA-B* 1301 is a common HLA allele in Taiwan, the number of HLA-B* 1301 alleles seen in control A and control B were 18 (8.9%) and 34 (8.9%), respectively (table 2). Unexpectedly, only one HLA-B* 1301 allele was found among the 33 probable SARS cases (case 30, table 1, 2). When testing HLA-B* 1301 with the 33 probable SARS cases, both control A and control B showed elevated odds ratios (OR = 0.16, P = 0.03, Pc = n.s. and OR = 0.16, P = 0.02, Pc = n.s., respectively)." ],
[ pmc:annotations [ pmc:id "163" ;
pmc:infons [ pmc:identifier "3106" ;
pmc:ncbi_homologene "134029" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "8560"^^xsd:int ] ;
pmc:text "HLA-B" ] ;
pmc:infons [ pmc:file "T3.xml" ;
pmc:id "T3" ;
pmc:section "Methods" ;
pmc:section_type "TABLE" ;
pmc:type "table_caption" ] ;
pmc:offset "8560"^^xsd:int ;
pmc:text "HLA-B* 4601 allele and 6 deceased or intubated probable SARS patients" ],
[ pmc:infons [ pmc:fpage "271" ;
pmc:lpage "287" ;
pmc:name_0 "surname:De Vries;given-names:RRP" ;
pmc:name_1 "surname:Meera Khan;given-names:VP" ;
pmc:name_2 "surname:Bernini;given-names:LF" ;
pmc:name_3 "surname:van Loghem;given-names:E" ;
pmc:name_4 "surname:van Rood;given-names:JJ" ;
pmc:pub-id_pmid "521665" ;
pmc:section "Pre-publication history" ;
pmc:section_type "REF" ;
pmc:source "J Immunogenet" ;
pmc:type "ref" ;
pmc:volume "6" ;
pmc:year "1979" ] ;
pmc:offset "24985"^^xsd:int ;
pmc:text "Genetic control of survival in epidemics" ],
[ pmc:annotations [ pmc:id "157" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "7945"^^xsd:int ] ;
pmc:text "patients" ] ;
pmc:infons [ pmc:file "T2.xml" ;
pmc:id "T2" ;
pmc:section "Methods" ;
pmc:section_type "TABLE" ;
pmc:type "table_caption" ] ;
pmc:offset "7895"^^xsd:int ;
pmc:text "Allele odds ratios analysis between probable SARS patients and other groups" ],
[ pmc:infons [ pmc:name_0 "surname:Fisher;given-names:RA" ;
pmc:section "Pre-publication history" ;
pmc:section_type "REF" ;
pmc:source "Edinburg: Oliver and Boyd" ;
pmc:type "ref" ;
pmc:year "1958" ] ;
pmc:offset "24746"^^xsd:int ;
pmc:text "Statistical methods for research worker" ],
[ pmc:infons [ pmc:section "Methods" ;
pmc:section_type "METHODS" ;
pmc:type "title_2" ] ;
pmc:offset "12032"^^xsd:int ;
pmc:text "Controls" ],
[ pmc:annotations [ pmc:id "161" ;
pmc:infons [ pmc:identifier "4698" ;
pmc:ncbi_homologene "3664" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "3"^^xsd:int ;
pmc:offset "8345"^^xsd:int ] ;
pmc:text "B13" ],
[ pmc:id "160" ;
pmc:infons [ pmc:identifier "3123" ;
pmc:ncbi_homologene "136635" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "3"^^xsd:int ;
pmc:offset "8115"^^xsd:int ] ;
pmc:text "HLA" ] ;
pmc:infons [ pmc:File "T2.xml" ;
pmc:id "T2" ;
pmc:section "Methods" ;
pmc:section_type "TABLE" ;
pmc:type "table" ] ;
pmc:offset "7971"^^xsd:int ;
pmc:text " 33 CasesProbableSARSpatients 28 feverpatients Control A101 high risk non-infectedhealth care workers Control B 190 healthy unrelated Taiwanese HLA alleles Total number of allelesn = 66 Total number of allelesn = 56 P Total number of allelesn = 202 OR CI P Total number of allelesn = 380 OR CI P B* 4601/B46 15 9 n.s. 25 2.08 1.04-4.24 0.04 52 1.86 1.02-3.54 0.06 B* 1301/B13 1 3 n.s. 18 0.16 0.02-1.00 0.03 34 0.16 0.02-0.97 0.02 B* 5401/B54 5 3 n.s. 3 5.44 1.26-23.41 0.02 15 1.99 1.01-5.69 n.s. B* 3901/B39 5 2 n.s. 6 2.68 0.78-9.08 n.s. 8 3.81 1.21-12.03 0.03 " ],
[ pmc:infons [ pmc:fpage "147" ;
pmc:lpage "175" ;
pmc:name_0 "surname:Meachem;given-names:W" ;
pmc:name_1 "surname:Keightly DK" ;
pmc:section "Pre-publication history" ;
pmc:section_type "REF" ;
pmc:source "In The origins of Chinese civilization" ;
pmc:type "ref" ;
pmc:year "1981" ] ;
pmc:offset "25543"^^xsd:int ;
pmc:text "Origins and development of the Yueh coastal Neolithic: A microcosm of culture change of the mainland of East Asia" ],
[ pmc:infons [ pmc:section "Methods" ;
pmc:section_type "METHODS" ;
pmc:type "title_2" ] ;
pmc:offset "13964"^^xsd:int ;
pmc:text "Statistical analysis" ],
[ pmc:annotations [ pmc:id "332" ;
pmc:infons [ pmc:identifier "3123" ;
pmc:ncbi_homologene "136635" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "3"^^xsd:int ;
pmc:offset "17207"^^xsd:int ] ;
pmc:text "HLA" ],
[ pmc:id "335" ;
pmc:infons [ pmc:identifier "MESH:D045169" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "14"^^xsd:int ;
pmc:offset "17623"^^xsd:int ] ;
pmc:text "SARS infection" ],
[ pmc:id "324" ;
pmc:infons [ pmc:identifier "3106" ;
pmc:ncbi_homologene "134029" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "17561"^^xsd:int ] ;
pmc:text "HLA-B" ],
[ pmc:id "329" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "17110"^^xsd:int ] ;
pmc:text "patients" ],
[ pmc:id "325" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "16580"^^xsd:int ] ;
pmc:text "patients" ],
[ pmc:id "331" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "17434"^^xsd:int ] ;
pmc:text "patients" ],
[ pmc:id "328" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "7"^^xsd:int ;
pmc:offset "16961"^^xsd:int ] ;
pmc:text "patient" ],
[ pmc:id "323" ;
pmc:infons [ pmc:identifier "3106" ;
pmc:ncbi_homologene "134029" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "17545"^^xsd:int ] ;
pmc:text "HLA-B" ],
[ pmc:id "327" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "3"^^xsd:int ;
pmc:offset "16851"^^xsd:int ] ;
pmc:text "man" ],
[ pmc:id "336" ;
pmc:infons [ pmc:identifier "MESH:D007676" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "21"^^xsd:int ;
pmc:offset "16870"^^xsd:int ] ;
pmc:text "chronic renal failure" ],
[ pmc:id "321" ;
pmc:infons [ pmc:identifier "3106" ;
pmc:ncbi_homologene "134029" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "16802"^^xsd:int ] ;
pmc:text "HLA-B" ],
[ pmc:id "322" ;
pmc:infons [ pmc:identifier "3106" ;
pmc:ncbi_homologene "134029" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "17304"^^xsd:int ] ;
pmc:text "HLA-B" ],
[ pmc:id "337" ;
pmc:infons [ pmc:identifier "MESH:D010437" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "12"^^xsd:int ;
pmc:offset "16893"^^xsd:int ] ;
pmc:text "peptic ulcer" ],
[ pmc:id "330" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "7"^^xsd:int ;
pmc:offset "17359"^^xsd:int ] ;
pmc:text "patient" ],
[ pmc:id "334" ;
pmc:infons [ pmc:identifier "MESH:D003327" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "22"^^xsd:int ;
pmc:offset "16910"^^xsd:int ] ;
pmc:text "coronary heart disease" ],
[ pmc:id "326" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "16640"^^xsd:int ] ;
pmc:text "patients" ],
[ pmc:id "333" ;
pmc:infons [ pmc:identifier "MESH:D005334" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "17428"^^xsd:int ] ;
pmc:text "fever" ] ;
pmc:infons [ pmc:section "Results" ;
pmc:section_type "RESULTS" ;
pmc:type "paragraph" ] ;
pmc:offset "16559"^^xsd:int ;
pmc:text "The 33 probable SARS patients also included 6 severe cases among whom three were patients who had been intubated for mechanical ventilation and five were deceased (table 1). Except for case 22 (table 1 and 3), the remaining five cases carried HLA-B* 4601. Case 22, however was a 91 years old man suffering from chronic renal failure, peptic ulcer and coronary heart disease. The cause of death of this patient was unlikely due to SARS alone and the case was removed from this group. The remaining 5 cases, labeled \"Deceased or intubated probable SARS patients\" in table 4, were retained for the analysis on the severity of SARS. The association of HLA class I and the severity of SARS was evidenced by an important increase of the odds ratio of HLA-B* 4601 in the deceased or intubated probable SARS patient group against all other groups, notably with the 28 excluded fever patients (OR = 7.83, P = 0.007, Pc = n.s.) and with control A (OR = 10.62, P = 0.0008, Pc = 0.0279) (table 4). HLA-B* 5401 and HLA-B* 3901/B39 did not show association with the severity of SARS infection (data not shown)." ],
[ pmc:annotations [ pmc:id "61" ;
pmc:infons [ pmc:identifier "3106" ;
pmc:ncbi_homologene "134029" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "2077"^^xsd:int ] ;
pmc:text "HLA-B" ],
[ pmc:id "69" ;
pmc:infons [ pmc:identifier "MESH:D045169" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "14"^^xsd:int ;
pmc:offset "1855"^^xsd:int ] ;
pmc:text "SARS infection" ],
[ pmc:id "60" ;
pmc:infons [ pmc:identifier "3106" ;
pmc:ncbi_homologene "134029" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "2038"^^xsd:int ] ;
pmc:text "HLA-B" ],
[ pmc:id "66" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "7"^^xsd:int ;
pmc:offset "2182"^^xsd:int ] ;
pmc:text "patient" ],
[ pmc:id "68" ;
pmc:infons [ pmc:identifier "MESH:D045169" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "14"^^xsd:int ;
pmc:offset "2371"^^xsd:int ] ;
pmc:text "SARS infection" ],
[ pmc:id "67" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "7"^^xsd:int ;
pmc:offset "2273"^^xsd:int ] ;
pmc:text "patient" ],
[ pmc:id "63" ;
pmc:infons [ pmc:identifier "3106" ;
pmc:ncbi_homologene "134029" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "2338"^^xsd:int ] ;
pmc:text "HLA-B" ],
[ pmc:id "62" ;
pmc:infons [ pmc:identifier "3106" ;
pmc:ncbi_homologene "134029" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "2108"^^xsd:int ] ;
pmc:text "HLA-B" ],
[ pmc:id "64" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "1907"^^xsd:int ] ;
pmc:text "patients" ],
[ pmc:id "65" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "7"^^xsd:int ;
pmc:offset "1954"^^xsd:int ] ;
pmc:text "peoples" ] ;
pmc:infons [ pmc:section "Abstract" ;
pmc:section_type "ABSTRACT" ;
pmc:type "abstract" ] ;
pmc:offset "1730"^^xsd:int ;
pmc:text "Densely populated regions with genetically related southern Asian populations appear to be more affected by the spreading of SARS infection. Up until recently, no probable SARS patients were reported among Taiwan indigenous peoples who are genetically distinct from the Taiwanese general population, have no HLA-B* 4601 and have high frequency of HLA-B* 1301. While increase of HLA-B* 4601 allele frequency was observed in the \"Probable SARS infected\" patient group, a further significant increase of the allele was seen in the \"Severe cases\" patient group. These results appeared to indicate association of HLA-B* 4601 with the severity of SARS infection in Asian populations. Independent studies are needed to test these results." ],
[ pmc:annotations [ pmc:id "503" ;
pmc:infons [ pmc:identifier "3123" ;
pmc:ncbi_homologene "136635" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "3"^^xsd:int ;
pmc:offset "25657"^^xsd:int ] ;
pmc:text "HLA" ] ;
pmc:infons [ pmc:fpage "676" ;
pmc:lpage "679" ;
pmc:name_0 "surname:Chen;given-names:RB" ;
pmc:name_1 "surname:Ye;given-names:GY" ;
pmc:name_10 "surname:Tsuji K, Aizawa M, Sasazuki T" ;
pmc:name_2 "surname:Geng;given-names:ZC" ;
pmc:name_3 "surname:Wang;given-names:ZH" ;
pmc:name_4 "surname:Kong;given-names:FH" ;
pmc:name_5 "surname:Tian;given-names:D" ;
pmc:name_6 "surname:Bao;given-names:PY" ;
pmc:name_7 "surname:Liu;given-names:RY" ;
pmc:name_8 "surname:Liu;given-names:J" ;
pmc:name_9 "surname:Song;given-names:FJ" ;
pmc:section "Pre-publication history" ;
pmc:section_type "REF" ;
pmc:source "In HLA 1991 Proceedings of the 11th International Histocompatibility Workshop and Conference" ;
pmc:type "ref" ;
pmc:volume "1" ;
pmc:year "1992" ] ;
pmc:offset "25657"^^xsd:int ;
pmc:text "HLA polymorphism of the principal minorities, in mainland China" ],
[ pmc:annotations [ pmc:id "497" ;
pmc:infons [ pmc:identifier "12637" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "12"^^xsd:int ;
pmc:offset "25306"^^xsd:int ] ;
pmc:text "dengue virus" ],
[ pmc:id "496" ;
pmc:infons [ pmc:identifier "3106" ;
pmc:ncbi_homologene "134029" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "11"^^xsd:int ;
pmc:offset "25259"^^xsd:int ] ;
pmc:text "HLA-A and B" ] ;
pmc:infons [ pmc:fpage "309" ;
pmc:lpage "318" ;
pmc:name_0 "surname:Stephen;given-names:HA" ;
pmc:name_1 "surname:Klaythong;given-names:R" ;
pmc:name_2 "surname:Sirikong;given-names:M" ;
pmc:name_3 "surname:Vaughn;given-names:DW" ;
pmc:name_4 "surname:Green;given-names:S" ;
pmc:name_5 "surname:Kalayanarooj;given-names:S" ;
pmc:name_6 "surname:Endy;given-names:TP" ;
pmc:name_7 "surname:Nisalak;given-names:A" ;
pmc:name_8 "surname:Rothman;given-names:AL" ;
pmc:name_9 "surname:Innis;given-names:BL" ;
pmc:pub-id_doi "10.1034/j.1399-0039.2002.600405.x" ;
pmc:pub-id_pmid "12472660" ;
pmc:section "Pre-publication history" ;
pmc:section_type "REF" ;
pmc:source "Tissue Antigens" ;
pmc:type "ref" ;
pmc:volume "60" ;
pmc:year "2002" ] ;
pmc:offset "25259"^^xsd:int ;
pmc:text "HLA-A and B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais" ],
[ pmc:annotations [ pmc:id "483" ;
pmc:infons [ pmc:identifier "3123" ;
pmc:ncbi_homologene "136635" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "3"^^xsd:int ;
pmc:offset "24786"^^xsd:int ] ;
pmc:text "HLA" ] ;
pmc:infons [ pmc:fpage "249" ;
pmc:lpage "257" ;
pmc:name_0 "surname:Edward;given-names:JH" ;
pmc:section "Pre-publication history" ;
pmc:section_type "REF" ;
pmc:source "Immunogenet" ;
pmc:type "ref" ;
pmc:volume "1" ;
pmc:year "1974" ] ;
pmc:offset "24786"^^xsd:int ;
pmc:text "HLA and disease, the detection of associations" ],
[ pmc:annotations [ pmc:id "121" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "5319"^^xsd:int ] ;
pmc:text "patients" ],
[ pmc:id "132" ;
pmc:infons [ pmc:identifier "MESH:D004492" ;
pmc:type "Chemical" ] ;
pmc:locations [ pmc:length "4"^^xsd:int ;
pmc:offset "4398"^^xsd:int ] ;
pmc:text "EDTA" ],
[ pmc:id "130" ;
pmc:infons [ pmc:identifier "MESH:D005334" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "5313"^^xsd:int ] ;
pmc:text "fever" ],
[ pmc:id "129" ;
pmc:infons [ pmc:identifier "MESH:D005334" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "4422"^^xsd:int ] ;
pmc:text "fever" ],
[ pmc:id "125" ;
pmc:infons [ pmc:identifier "MESH:D008171" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "12"^^xsd:int ;
pmc:offset "5533"^^xsd:int ] ;
pmc:text "lung lesions" ],
[ pmc:id "122" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "5374"^^xsd:int ] ;
pmc:text "patients" ],
[ pmc:id "126" ;
pmc:infons [ pmc:identifier "MESH:D014376" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "12"^^xsd:int ;
pmc:offset "5465"^^xsd:int ] ;
pmc:text "tuberculosis" ],
[ pmc:id "117" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "4428"^^xsd:int ] ;
pmc:text "patients" ],
[ pmc:id "133" ;
pmc:infons [ pmc:identifier "MESH:D012131" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "19"^^xsd:int ;
pmc:offset "4442"^^xsd:int ] ;
pmc:text "respiratory illness" ],
[ pmc:id "120" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "7"^^xsd:int ;
pmc:offset "5147"^^xsd:int ] ;
pmc:text "patient" ],
[ pmc:id "128" ;
pmc:infons [ pmc:identifier "MESH:D005334" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "5368"^^xsd:int ] ;
pmc:text "fever" ],
[ pmc:id "124" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "7"^^xsd:int ;
pmc:offset "5483"^^xsd:int ] ;
pmc:text "patient" ],
[ pmc:id "123" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "5395"^^xsd:int ] ;
pmc:text "patients" ],
[ pmc:id "131" ;
pmc:infons [ pmc:identifier "MESH:D004487" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "10"^^xsd:int ;
pmc:offset "5501"^^xsd:int ] ;
pmc:text "lung edema" ],
[ pmc:id "127" ;
pmc:infons [ pmc:identifier "MESH:D011014" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "10"^^xsd:int ;
pmc:offset "5445"^^xsd:int ] ;
pmc:text "pneumonias" ],
[ pmc:id "118" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "7"^^xsd:int ;
pmc:offset "4865"^^xsd:int ] ;
pmc:text "patient" ],
[ pmc:id "119" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "4978"^^xsd:int ] ;
pmc:text "patients" ] ;
pmc:infons [ pmc:section "Methods" ;
pmc:section_type "METHODS" ;
pmc:type "paragraph" ] ;
pmc:offset "4033"^^xsd:int ;
pmc:text "In the course of March 19 to May 22, 2003, 93 cases of suspected SARS were reported by Mackay Memorial Hospital in Taipei City and its branch in Tan Sui County of Taipei to the Center for Disease Control in Taiwan. Up until early June, among 680 probable SARS cases reported in Taiwan, 71 (10.4%) cases were admitted to our hospital. Between May 5 and 26, 2003, 63 EDTA blood samples from fever patients with respiratory illness were collected in our hospitals. Two earlier specimens from the National Taiwan University Hospital (Taipei) were added to this study. Of the 65 (63+2) cases, 37 cases (table 1) were diagnosed as probable SARS cases according to updated WHO case definition for SARS (revised May 1, 2003). Three families were included (cases 31 and 32; cases 33 and 34; and cases 35, 36 and 37). Only the first infected patient in each family (cases 31, 33, 35) was retained for the analysis giving a final count of 33 probable SARS patients. Nine unrelated individuals (cases 7, 13, 18, 19, 21, 22, 26, 27, and 31) were infected from the same source (unfortunately this \"super-spreader\" probable SARS patient died 24 hours after admission in hospital and was not studied). Twenty eight cases of the 65 cases were not positive for SARS, and were referred as \"Excluded fever patients\" in tables 2 and 4. Among the \"Excluded fever patients\" group, two patients showed positive serological tests for M. pneumonias, one had tuberculosis, one patient presented lung edema, and the rest had no lung lesions." ],
[ pmc:infons [ pmc:section "Pre-publication history" ;
pmc:section_type "SUPPL" ;
pmc:type "title_1" ] ;
pmc:offset "24293"^^xsd:int ;
pmc:text "Pre-publication history" ],
[ pmc:infons [ pmc:section "Results" ;
pmc:section_type "RESULTS" ;
pmc:type "title_1" ] ;
pmc:offset "14892"^^xsd:int ;
pmc:text "Results" ],
[ pmc:annotations [ pmc:id "47" ;
pmc:infons [ pmc:identifier "MESH:D018352" ;
pmc:type "Disease" ] ;
pmc:locations [ pmc:length "21"^^xsd:int ;
pmc:offset "1153"^^xsd:int ] ;
pmc:text "coronavirus infection" ],
[ pmc:id "42" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "7"^^xsd:int ;
pmc:offset "1484"^^xsd:int ] ;
pmc:text "patient" ],
[ pmc:id "43" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "7"^^xsd:int ;
pmc:offset "1532"^^xsd:int ] ;
pmc:text "patient" ],
[ pmc:id "46" ;
pmc:infons [ pmc:type "Chemical" ] ;
pmc:locations [ pmc:length "7"^^xsd:int ;
pmc:offset "987"^^xsd:int ] ;
pmc:text "Haldane" ],
[ pmc:id "41" ;
pmc:infons [ pmc:identifier "9606" ;
pmc:type "Species" ] ;
pmc:locations [ pmc:length "8"^^xsd:int ;
pmc:offset "1215"^^xsd:int ] ;
pmc:text "patients" ],
[ pmc:id "40" ;
pmc:infons [ pmc:identifier "3106" ;
pmc:ncbi_homologene "134029" ;
pmc:type "Gene" ] ;
pmc:locations [ pmc:length "5"^^xsd:int ;
pmc:offset "1314"^^xsd:int ] ;