diff --git a/.github/CODEOWNERS b/.github/CODEOWNERS
index 16ec1b204..6a09ae3cd 100644
--- a/.github/CODEOWNERS
+++ b/.github/CODEOWNERS
@@ -1,14 +1,15 @@
+**/brain** @icaoberg
 **/ceci_** @MartinGrignard
+**/crg** @joseespinosa
 **/cropdiversityhpc** @TMAdams @SwiftSeal @SchreiberM
+**/fred_hutch** @derrik-gratz
 **/giga** @MartinGrignard
+**/iris** @nikhil
+**/lrz_cm4** @nschan
+**/mahuika** @jen-reeve
+**/roslin** @sguizard @donalddunbar
+**/seadragon** @jiawku
 **/shu_bmrc** @lquayle88
+**/unsw_katana** @jscgh
 **/utd_ganymede** @edmundmiller @alyssa-ab
 **/utd_juno** @eternal-flame-AD
-**/unsw_katana** @jscgh
-**/seadragon** @jiawku
-**/fred_hutch** @derrik-gratz
-**/roslin** @sguizard @donalddunbar
-**/lrz_cm4** @nschan
-**/crg** @joseespinosa
-**/iris** @nikhil
-**/mahuika** @jen-reeve
diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index dc90421d2..09f3acc5a 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -79,6 +79,7 @@ jobs:
           - "biohpc_gen"
           - "biowulf"
           - "bluebear"
+          - "brain"
           - "cambridge"
           - "cannon"
           - "cbe"
diff --git a/conf/brain.config b/conf/brain.config
new file mode 100644
index 000000000..82c7ec795
--- /dev/null
+++ b/conf/brain.config
@@ -0,0 +1,72 @@
+// ─────────────────────────────────────────────────────────────────────────────
+// Global Parameters
+// ─────────────────────────────────────────────────────────────────────────────
+params {
+    config_profile_name        = 'Brain Image Library Analysis Ecosystem'
+    config_profile_description = 'A public resource enabling researchers to deposit, analyze, mine, share, and interact with large brain image datasets.'
+    config_profile_url         = 'https://www.brainimagelibrary.org'
+    config_profile_contact     = 'Ivan Cao-Berg (@icaoberg)'
+
+    // General resource boundaries (used in profile as well)
+    max_memory = 2.9.Tb
+    max_cpus   = 80
+    max_time   = 48.h
+
+    // Ignore iGenomes when not needed
+    igenomes_ignore = true
+    igenomesIgnore  = true
+}
+
+// ─────────────────────────────────────────────────────────────────────────────
+// Singularity Configuration
+// ─────────────────────────────────────────────────────────────────────────────
+singularity {
+    enabled     = true
+    autoMounts  = true
+    runOptions  = '''
+        --home $HOME:/bil/users/$USER \
+        --bind /scratch \
+        --bind /local
+    '''
+}
+
+// ─────────────────────────────────────────────────────────────────────────────
+// Executor Configuration
+// ─────────────────────────────────────────────────────────────────────────────
+executor {
+    queueSize       = 10
+    submitRateLimit = '5 sec'
+}
+
+// ─────────────────────────────────────────────────────────────────────────────
+// Profiles
+// ─────────────────────────────────────────────────────────────────────────────
+profiles {
+    compute {
+        params {
+            config_profile_name        = 'BIL - General Computing Partition'
+            config_profile_description = 'Brain Image Library Analysis Ecosystem at the Pittsburgh Supercomputing Center'
+            config_profile_url         = 'https://www.brainimagelibrary.org'
+            config_profile_contact     = 'Ivan Cao-Berg (@icaoberg)'
+        }
+
+        process {
+            executor        = 'slurm'
+            queue           = 'compute'
+            queueSize       = 10
+            clusterOptions  = '--qos=normal'
+
+            // Set scratch directory to /local
+            scratch        = true
+            scratchMount   = '/local'
+
+            // Default per-process limits
+            resourceLimits = [
+                memory: 128.Gb,
+                cpus  : 16,
+                time  : 4.h
+            ]
+        }
+    }
+}
+
diff --git a/docs/brain.md b/docs/brain.md
new file mode 100644
index 000000000..3aeae3200
--- /dev/null
+++ b/docs/brain.md
@@ -0,0 +1,25 @@
+# nf-core/configs: Brain Image Library Analysis Ecosystem Configuration
+
+All nf-core pipelines have been successfully configured for use on the Brain Image Libraryy (BIL) cluster at the Pittsburgh Supercomputing Center.
+
+To use, run the pipeline with `-profile brain`. This will download and launch the [`brain.config`](../conf/brain.config) which has been pre-configured with a setup suitable for the Brain Image Library (BIL) Analysis Ecosystem. Using this profile, a docker image containing all of the required software will be downloaded, and converted to a Singularity image before execution of the pipeline.
+
+## Running the workflow on the Brain Image Library (BIL) Analysis Ecosystem
+
+Nextflow is not installed by default on the Brain Image Library Analysis Ecosystem.
+
+- Install Nextflow : [here](https://www.nextflow.io/docs/latest/getstarted.html#)
+
+Nextflow manages each process as a separate job that is submitted to the cluster by using the `sbatch` command.
+
+Nextflow shouldn't run directly on a login node but on a compute node, so the `nextflow run` command should be also submitted using an `sbatch` command itself.
+
+For example, run the following Nextflow command on a compute node with submit host capability:
+
+```bash
+# Run nextflow workflow
+nextflow run \\
+nf-core/chipseq \\
+-resume \\
+-profile test,brain,compute
+```
diff --git a/nfcore_custom.config b/nfcore_custom.config
index 84f08c30c..de29165dc 100644
--- a/nfcore_custom.config
+++ b/nfcore_custom.config
@@ -58,6 +58,9 @@ profiles {
     bluebear {
         includeConfig "${params.custom_config_base}/conf/bluebear.config"
     }
+    brain {
+        includeConfig "${params.custom_config_base}/conf/brain.config"
+    }
     cambridge {
         includeConfig "${params.custom_config_base}/conf/cambridge.config"
     }