diff --git a/CHANGELOG.md b/CHANGELOG.md
index 11f39da52d..6797e4bb50 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -62,6 +62,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 - [#578](https://github.com/nf-core/sarek/pull/578) - Updated module deeptools/bamcoverage
 - [#585](https://github.com/nf-core/sarek/pull/585) - Remove explicit BAM to CRAM conversion after MarkduplicatesSpark; tool does it internally
 - [#581](https://github.com/nf-core/sarek/pull/581) - `TIDDIT` is updated to `3.1.0`
+- [#593](https://github.com/nf-core/sarek/pull/593) - update `ensembl-vep` cache version and module
 
 ### Fixed
 
diff --git a/conf/igenomes.config b/conf/igenomes.config
index b960797e5e..6634ef8cb5 100644
--- a/conf/igenomes.config
+++ b/conf/igenomes.config
@@ -29,7 +29,7 @@ params {
             mappability           = "${params.igenomes_base}/Homo_sapiens/GATK/GRCh37/Annotation/Control-FREEC/out100m2_hg19.gem"
             snpeff_db             = 'GRCh37.75'
             snpeff_genome         = 'GRCh37'
-            vep_cache_version     = 104
+            vep_cache_version     = 105
             vep_genome            = 'GRCh37'
             vep_species           = 'homo_sapiens'
         }
@@ -55,7 +55,7 @@ params {
             pon_tbi               = "${params.igenomes_base}/Homo_sapiens/GATK/GRCh38/Annotation/GATKBundle/1000g_pon.hg38.vcf.gz.tbi"
             snpeff_db             = 'GRCh38.99'
             snpeff_genome         = 'GRCh38'
-            vep_cache_version     = 104
+            vep_cache_version     = 105
             vep_genome            = 'GRCh38'
             vep_species           = 'homo_sapiens'
         }
@@ -107,7 +107,7 @@ params {
             fasta                 = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/WholeGenomeFasta/genome.fa"
             snpeff_db             = 'WBcel235.99'
             snpeff_genome         = 'WBcel235'
-            vep_cache_version     = 104
+            vep_cache_version     = 105
             vep_genome            = 'WBcel235'
             vep_species           = 'caenorhabditis_elegans'
         }
diff --git a/modules.json b/modules.json
index 5f69191ce0..0c330b13f3 100644
--- a/modules.json
+++ b/modules.json
@@ -67,7 +67,7 @@
                 "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d"
             },
             "ensemblvep": {
-                "git_sha": "30f72e24822576c6f90a0bf9db678b403c70eccf"
+                "git_sha": "757c20c8ebfab85e1de9f98773a2269f6d34025a"
             },
             "fastqc": {
                 "git_sha": "49b18b1639f4f7104187058866a8fab33332bdfe"
diff --git a/modules/nf-core/modules/ensemblvep/main.nf b/modules/nf-core/modules/ensemblvep/main.nf
index 391a182def..d9bd3e831f 100644
--- a/modules/nf-core/modules/ensemblvep/main.nf
+++ b/modules/nf-core/modules/ensemblvep/main.nf
@@ -2,10 +2,10 @@ process ENSEMBLVEP {
     tag "$meta.id"
     label 'process_medium'
 
-    conda (params.enable_conda ? "bioconda::ensembl-vep=104.3" : null)
+    conda (params.enable_conda ? "bioconda::ensembl-vep=105.0" : null)
     container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ?
-        'https://depot.galaxyproject.org/singularity/ensembl-vep:104.3--pl5262h4a94de4_0' :
-        'quay.io/biocontainers/ensembl-vep:104.3--pl5262h4a94de4_0' }"
+        'https://depot.galaxyproject.org/singularity/ensembl-vep:105.0--pl5321h4a94de4_1' :
+        'quay.io/biocontainers/ensembl-vep:105.0--pl5321h4a94de4_1' }"
 
     input:
     tuple val(meta), path(vcf)