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Follow Strelka BP and use Manta small indels candidates as input#556

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szilvajuhos merged 7 commits intoSciLifeLab:masterfrom
maxulysse:StrelkaBP
Apr 3, 2018
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Follow Strelka BP and use Manta small indels candidates as input#556
szilvajuhos merged 7 commits intoSciLifeLab:masterfrom
maxulysse:StrelkaBP

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@maxulysse
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new PR to replace #467
This is deactivated by default.
So it should be safe to merge if we want to try this new feature

@maxulysse maxulysse requested a review from szilvajuhos March 27, 2018 15:06
@maxulysse maxulysse changed the title Follow Strelka BP and use Manta small indels candidates Follow Strelka BP and use Manta small indels candidates as input Mar 27, 2018
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I think I can add this option for Germline as well, so do not merge yet.

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So bad idea to try to implement for germline, I should have read further.

The germline caller already includes its own assembly step, so indel candidate input from a tool like Manta is not recommended in this case (in testing, Manta candidate indels have been found to provide no benefit and in some cases may complicate the accurate resolution of a locus).

At least I read it before starting to do some work on it.

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Looks OK

@szilvajuhos szilvajuhos merged commit 2c40e28 into SciLifeLab:master Apr 3, 2018
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Eventually we could check on real data whether it improves indel calls.

@maxulysse maxulysse deleted the StrelkaBP branch April 3, 2018 07:55
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Of course, that why for the moment it's not working by default, but I hope to definitively use this functionality.
We can provide both VCFs from Strelka, for the moment, we now do have two different directories, so it'll be easy to check it out

jherrero referenced this pull request in UCL-BLIC/Sarek_v2.2.1 Apr 11, 2019
Follow Strelka BP and use Manta small indels candidates as input
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