Hi, I'm new to the world of drug synergy experiments and I'm using synergyfinder on R to compute 3-drug synergy scores for a research project. I'm having some trouble trying to determine if a combination is considered synergistic or not under a specific model. For example, I know that the Highest Single Agent score points to synergy when above zero and to antagonism when below zero but I can't understand if other scores (Bliss, ZIP, Loewe) have the same direction or not in your implementation. Could you help me figure out for each score what is the threshold value (like zero is for HSA) and their directions (for example above threshold value = synergy and below = antagonism or vice versa)?
Thank you in advance for your help :)
Hi, I'm new to the world of drug synergy experiments and I'm using synergyfinder on R to compute 3-drug synergy scores for a research project. I'm having some trouble trying to determine if a combination is considered synergistic or not under a specific model. For example, I know that the Highest Single Agent score points to synergy when above zero and to antagonism when below zero but I can't understand if other scores (Bliss, ZIP, Loewe) have the same direction or not in your implementation. Could you help me figure out for each score what is the threshold value (like zero is for HSA) and their directions (for example above threshold value = synergy and below = antagonism or vice versa)?
Thank you in advance for your help :)