Bridge RNA Designer

A web interface for designing Bridge RNAs for Bridge Editing.

References

Perry, N.T., Bartie, L.J., Katrekar, D. et al. Megabase-scale human genome rearrangement with programmable bridge recombinases. Science (2025). https://doi.org/10.1126/science.adz0276 Durrant, M.G., Perry, N.T., Pai, J.J. et al. Bridge RNAs direct programmable recombination of target and donor DNA. Nature 630, 984-993 (2024). https://doi.org/10.1038/s41586-024-07552-4 Hiraizumi, M., Perry, N.T., Durrant, M.G. et al. Structural mechanism of bridge RNA-guided recombination. Nature 630, 994–1002 (2024). https://doi.org/10.1038/s41586-024-07570-2

Webtool

Published app

Run locally

streamlit run app.py --server.address=0.0.0.0

CLI

See BridgeRNADesigner