Request plot: Hair aDNA plots with entire sequence damage

[jfy133]

@aidaanva getting the info

[jfy133]

https://www.nature.com/articles/s41598-022-25384-y

Figure 2

The second is that unusually high damage rates were observed in the interior of the DNA molecules from hair, while unusually low damage rates were seen in the exterior of the molecules. For instance, at the interior 10th bp from the 5’ end, damage rates were 10% compared to 1% from typical bone-derived aDNA. While at the exterior, the 1st bp from the 5’ end showed damage rates of 15%, compared to on average of 27%22 from typical bone-derived aDNA. These patterns are consistent with high degradation of DNA fragments in hair through intense sun exposure, already during the lifetime of the individual, which may result in hair containing largely denatured single-stranded DNA fragments, as opposed to the more typically intact double-stranded fragments preserved in bone samples.

[jfy133]

I guess maybe we should generate two, one after re-mapping before 25bp filtering (to see what it looks like) and again after (as in Figure 2)